u/simplystevie107

EDIT: I just reread the article and I realized that the TN focus is one they are hopeful about once they determine the process is safe. Right now they are focusing on diseases where they are dealing with a treatment of last resort since the genetic modifications are not yet proven safe. Sorry the confusion; I was reading a bunch of stuff I didn't quite understand and got ahead of myself since I was excited about a potential new treatment.

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It's just starting so we're quite a ways out from seeing if this works, but researchers in China have begun a human trial for a completely new approach for treating TN with chemogenetic therapy. The exciting part:

"According to Roth, the study with the greatest potential focuses on trigeminal neuropathic pain, which can be debilitating enough that it is a risk factor for suicide. “If that trial is successful, then it opens the way basically to circuit-based therapeutics for virtually all neuropsychiatric diseases,” he says."

Fingers crossed that this leads somewhere.

https://cen.acs.org/biological-chemistry/biotechnology/human-trial-chemogenetic-brain-therapy/104/web/2026/08

Hi, all. I few weeks ago I went in to have a derm look at what I was 90% sure was bcc. It was, and while they were doing a check we decided to biopsy a spot I had asked my regular doc about last year, even though he said it was fine. I bet you see where this is going... fortunately it was still only 1a. The melanoma is at a spot on my chest that almost isn't my chest- the fleshy spot way over to the side where it then goes into the arm pit. The biopsy healing has been worse than I expected because *every* time I move my arm, that area moves. I'm concerned that the movement is going to make the healing after the WLE more painful and make the scar worse.

Has anyone has a WLE in an area like this and, if so, how did you manage it? I really don't want to stretch the scar, but feel like it would be an overreaction to restrict my movement with a sling, but that's all I can think of to keep me from moving it. Does anyone have any advice or tips?

I also have a question about my bcc. I've had them in the past, but this is the first one on my face (sidewall of my nose) and my first MOHS. I wasn't even thinking about it because the biopsy was easy and I honestly thought MOHS would just be like that after they explained it to me- a few scrapes and a dot bandage for a day or two, then done. They never said those things, it's just how I interpreted it. Then I got something in the mail from them this week explaining the procedure and stitches and wound care, and potential redness and swelling for months, and now I'm almost as freaked about that as I am about the WLE. I'm trying to keep in mind that they talk about the worse case to control expectations and for liability reasons, but is it really that bad?

Thanks so much for any insight or advice you all have. I've learned a lot from this group and hope you all are feeling well. <3

edit- I also realize I'm overreacting to the MOHS thing. I think I had just convinced myself based on how the PA described it as a simple process of basically scraping the area a couple times, and so when I read the info I was surprised. I figured that since unfortunately these things tend to travel together that some of you may also be able to give some info about this, too. Thanks :-)

First human trials for potential new TN treatment starting in China

WLE healing and mobility of arm (and a bbc/MOHS question)