u/stopcopingaboutHF

To be honest, I haven't been posting much recently because I've essentially given up on this community as I see most of you as delusional lost causes. I've seen a marked reversion back to the old copes that this is caused by something like a muscular imbalance and fixable with pelvic floor PT or whatever. Whenever I say the obvious and intuitive fact that this is caused by some kind of tissue damage in the penis, I get dogpiled for negativity and ruining the vibes. You can lead a horse to water, but you can't make him drink. Most of you are psychologically weak so you have to keep lying to yourself about the cause of this to soften the blow and think that you can put this in your own control. That's just how I see it.

That said, despite my disillusionment, I do feel it necessary to give this subreddit some good news. There is a new neuroreparative peptide in clinical trials for spiral cord injuries called NVG-291. Without going into the pharmacological details and pathways in the body with a write-up of how it works, which would honestly be a waste of my time as most of you are either too lazy or too unintelligent to understand it (sorry, just keeping it real), it basically takes the brakes off of nerve regeneration and breaks down the scar tissue in nerves allowing them to be remodeled into healthy nerve tissue, and allows nerves to regrow through scar tissue. There is no reason why it would only be therapeutic in the spinal cord. In fact, in animal models, NVG-291 has shown very promising results for also treating Multiple Sclerosis and hearing loss. The side effects seem to be nonexistent, at least so far. Basically, this could be a real miracle drug for a wide variety of nervous system related disorders.

Here's a video of someone with a spinal cord injury from 9 years earlier (so not just in the acute phase) who was in the trial and their improvements in walk speed, https://vimeo.com/1139656943/8028c1f465

There are a handful of patients on the spinal cord injury subreddit who claimed to have been in the trials and basically described miraculous results in terms of regaining their motor function and ability to walk. If hard flaccid is caused by nerve damage, which I personally believe it is, this really shows some promise in being able to help the penis heal from nerve damage. Now, if the CRPS or central sensitization theory is correct, that leaves the question of whether this could even help with that and calm down the overactive nerves. But even so, this is the first real positive news that's actually given me hope that medicine could cure this hellish disease before I'm dead or an old man and my youth and ability to have a sex/dating life and wife and kids are completely gone.

The FDA is also fast-tracking it, so we shouldn't have to wait an agonizingly long time for this to get approved. Needless to say, this would be a very off-label use and we wouldn't be able to just get it, but as it's a peptide maybe it will be available from Chinese sellers on the gray market with crypto like GLP-1s and other peptides. The Phase 2 results should be out very soon, they must have been good because they had a successful meeting with the FDA about it, https://nervgen.com/nervgen-pharma-announces-successful-end-of-phase-2-meeting-and-fda-alignment-on-restore-a-phase-3-registrational-study-of-nvg-291-for-chronic-tetraplegia/