u/tangoan

I understand L. reuteri DSM 17938 came from the breast milk of a mother living in the Andes mountains of Peru, but I read that this strain was genetically modified prior to commercial use to delete two genes associated with antibiotic resistance.

Firstly, do I have this right?

Second, why would they feel the need to do this? Could this modification have contributed to this strain’s inability to permanently colonize the human gut?

Last, are there any L. reuteri strains commercially available that are not genetically modified?

Thank you!

edit:

Adding additional questions to clarify my line of thinking:

Why would antibiotic resistance be deemed a problematic quality of L. reuteri, a beneficial communal bacteria? Deleting a gene within one species wouldn’t confer antibiotic resistance to other species or strains. What research or line of thinking led them to believe this was necessary for this strain?

Has there been documented pathogenic behavior of L. reuteri infection that was found to be antibiotic resistant? Is this a normal step in commercializing all probiotic strains?

Since L. reuteri is considered to be a strain that is readily lost upon antibiotic use without return, why would these researchers consider antibiotic resistance a problem that needed to be addressed?

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