r/Immunology

We have published a preprint titled “Evolutionary shifts in spike glycan-binding specificity suggest a possible association with host adaptation during SARS-CoV-2 Omicron evolution” .

Just bought the Dynabeads T cell activation beads, and the protocol says to wash them first with the help of a magnet... How important is this step? We do not have the magnet... Anyone try an alternate method of washing and/or skipping washing altogether?

Just got some human recombinant interleukin 2 from peprotech, and looks like it needs to be reconstituted initially in Acetic acid... how critical is this? Could I use something else, like hydrochloric acid or just plain dPBS/water? Anyone try anything different?

For my thesis in microbiology II I picked the topic above as my field of interest. I found that the foreskin has so many benefits from an immunological perspective. My paper is peer reviewed by an MD named Dr Mary Zhang MD, she was my professor and used to be a Chinese cardiologist.

Hi all!

I recently graduated with a Master's in Microbiology and Immunology (immunology track) after not completing my PhD. Long story short, I fell out of love with academia and research as a whole as I saw practices that were questionable at best with the publish or perish culture. Bad mentorship fit was also a very significant reason why. I was 5 years in before things went off the rails so I essentially did a free Masters in 5 years. Tried to get the degree with the little motivation and support I had at the end but eventually caved in to get out.

I did all the good stuff in immunology especially Flow Cytometry (conventional + spectral), Immunohistochemistry, qPCR, primary immune cell culture, amongst other things. My research was centered around intestinal immunology and studying tissue resident memory T cells following oral vaccinations. I have been looking for a job for 3 months right now and I thought I'd have several outings with my degree/experience but I am sort of realizing that this is not the case. I am planning on working as a clinical research coordinator to get some clinical skills under my belt and this might be my long term goal for now.

I am looking to see if anyone has any experience with a Masters in Immunology or if you know somebody who's gone or is going through a similar situation as I am? I think I don't want to go back to the bench but I want to stay close to the science. Have thought about medical science liaison jobs but I am seeing that those are mostly MD- or PhD-gated. Happy to hear any of your thoughts!

What role do gut flora have in regulating immune function and by what mechanism?

Helloo! I’m currently in Year 12 in Australia (vic) and I’m really interested in pursuing a career in immunology. I’m planning to complete a Bachelor of Science majoring in immunology, and completing honours and maybe even a PhD afterwards. I’ve been doing a lot of research into different careers, but I’m still a little confused about the differences between roles like immunologists and immunology researchers.

I was hoping to get some insight into what the day-to-day life is actually like for someone working in these fields — what kind of tasks you do, what your work environment is like, and what education/pathway you completed to get there. Do you enjoy the work-life balance and career opportunities? What is the pay like? (if you feel comfortable sharing!)

I would love to study and research pathogens and immune responses.

Would really appreciate hearing about your experiences or any advice!

Hello
I just found out I have high natural killer cells… my IVf doctor hasn’t come back to me as it’s the weekend. I’m day 12 of a natural cycle preparing for a FET. Is it too late to start taking steroids? Or what point in the cycle do you start taking them??
Hopefully my doctor will reply eventually but please let me know if you know! Thanks!

New to immunology. 57 y/o male with a history of multiple complicated diverticulitis flares, sepsis, sigmoidectomy, and severe persistent asthma. Doc wanted to explore reasons for frequent infections. Found out this week from labs that my IgG <75. My IgA and IgM are normal. Had labs in 2023 for asthma testing and my IgG was in the 900s. Went septic from a bad diverticulitis episode in 2024. Had my sigmoid colon removed in 2025. Just recovered from another diverticulitis flare in another part of my colon. Doc was alarmed by my labs and referred me for an "urgent" immunologist appointment on Monday. From what I've been reading, IVIG or SCIG are the likely next steps. I know it's a basic question, but what should I expect during the next few weeks? Thanks for any information you have.

Family had a stomach bug recently. Despite all of us doing/eating the same things, they vomited all over the place on multiple days, yet I just felt a little queasy for a couple hours. I'm confident I was exposed to whatever they had. Since we've been together so long, I assume our immune systems are similar/exposed to the same things

Hi everyone, I'm the developer of Voxcyte. I came from a background in physiology before moving into data science and software engineering.

Voxcyte is an app that runs flow cytometry analysis natively on macOS. No browser, no cloud, no Java. Everything is local and your data never leaves your Mac.

The standout feature is a real-time interactive 3D scatter plot you can rotate and zoom, staying smooth across millions of events. Most tools either can't do 3D like this or lag on large files. It's built for Apple Silicon, so most actions are instant and even heavy operations on large files only take a few seconds.

Voxcyte is a complete analysis app including compensation, gating, 2D/3D/histogram plots, statistics, and publication-ready figure exports. It's also more affordable than some established tools, and you can try it with a 14-day free trial, no card.

I take feedback seriously and act on it fast, so if something doesn't fit your workflow or you run into an issue, just contact me and it will likely be in the next release.

https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2026.1792210/full