r/Immunology

I'm a college student in biology, and I've been cheking on this article talking about the consequences of the first pulmonar infection on SPF mices.
So far, I ot everything, but I got a little comprehension issue with one panel of this study. Here, there's a mention of "P14 D-1" cells (wich en T-cells) and "OT-1" cells (also T-cells).
I believe those are naive cells that we use to track the infection 'cause they're easy to track, but I don't think it's 100% it.

Could you guys give me your thought ?

https://preview.redd.it/e1dtxtftd92h1.png?width=507&format=png&auto=webp&s=d6d68f8cdd437822bf92a5c474f3dd57b87cbad8

(here they're testing what are the chances for mices that experienced a previous infection to get better faster than the naive mices (wich are SPF)

I'm a fundamental genomics grad student wondering why does adaptive immunity get more attention?

Here's my thought - Sure, adaptive is the more precise and acts during an organisms lifetime. It lends itself to precision medicine via receptor engineering or Car-t cell therapy. Yet, so much of the efficacy of adaptive immunity relies on interactions with the innate immune system. Cytokine reactions, dendritic cells, mucosal immunity etc. In this sense, innate is less easily actionable by current bioengineering approaches.

What're yours?

A couple hypothesis generating questions for a research idea:

1. Have you ever seen MCAS mimicking a vasculitis at initial presentation?
2. If so, what type of vasculitis?
3. What made you ultimately realize it was MCAS vs a vasculitis?

Hey everyone,

I’m new to bioinformatics and diving into adaptive immune receptor repertoire (AIRR) data. I'm looking for the best databases or pipelines to handle two things:

Query Repertoire Data: Find public BCR/TCR sequence datasets.

Epitope Prediction: Predict antigen specificity for those sequences, or find data where the mapping is already done.

Are there any reliable "all-in-one" platforms for this, or should I expect to pair a data repository (like iReceptor or VDJdb) with separate ML tools?

Any web portal, Python, or R recommendations for a beginner would be awesome. Thanks!

Hi! I am (given that I meet my conditional offer lol) going into medical school this autumn, and although I realise that it is definitely too early to start thinking about specialties, I would like to know more about what an immunologist does. I assume this subreddit is about immunology in general, but if anybody happens to be an immunologist or is familiar with what it entails as a career I am so curious to hear everything about it! It does sound cliché, but I have always been interested in the immune system in different ways. As a kid, I was fascinated with bacteria, viruses and parasites, and basically all of my science projects through both primary and middle school were about patogens and our body's reaction to them. Much like many others, my interest further peaked during COVID, but it is during my highschool years that I have really gotten more curious about immunology as a whole. Many people in my family have autoimmune conditions (psoriasis, rheumatoid arthritis, MS), and what I find particularly interesting is how infections with some viruses can lead to these autoimmune conditions later in life (like the EBV and MS link).

Anyways, I would really like to know how a both careers within medical research and clinical practice are for an immunologist - what do you do on a daily basis? I have so many questions to ask, so if you are familiar with the field please message me : )

As someone with an Immunoglobulin A deficiency, I find I can't travel without getting a bad cold, even after wearing a mask on the plane. It's discouraging. Is this something others experience?

Woman posted on a Backyard Chicken group to find someone with such eggs. I began to consider if there's any research or evidence to support this claim, or no.

Hi everyone! I have a presentation due TOMORROW that I just remembered about gamma delta T cells and I don’t have time to read all the articles i saved!! Help

I’m confused about how it activates and effector functions. Does it come pre activated from the thimus and then it activates due to stress, damaged cells and stuff?

Is this the part where it “decided” which cytokine is going to express?

Also effector functions?? Help lol

Do you think there is something i should not forget to talk about? Just so i can check my slides

Thank you

I’ve been having flares for several years with gradually increasing severity. My reactions have been mainly systemic inflammation, then migraines (starting 2022) and now some gastrointestinal. Never hives or breathing difficulties (though I do get a tight throat). Triggers are stress, too much light, too much sound, screens, various foods, preservatives, too much activity (even three sets of light weights now), humidity, heat, and sudden cold. Finally found a doctor who has suggested it could be mcas, praise jaysus. Taking dihydrate at night, some fexo gives me headaches, still experimenting with other anti histamine while waiting to see immunologist in six weeks. I find quercetin helps too so going to start taking that daily. Also started on Monjauro twice a week which has helped enormously with brain fog but its ups and downs still play havoc with my system.

Questions:

1. Hoping to get advice on what to ask the immunologist when I get there, it’s a two hour drive and need to get the most out of it.

2. I also want to explore getting income protection, I know my fund says I have to be unable to work for two weeks then cannot work after that before applying. I’ve been working but lord can only get through the day relying heavily on ChatGPT (I’m a writer and content producer). Has anyone else successfully done this, and what challenges were there?