r/LiverDisease

▲ 5 r/LiverDisease+1 crossposts

Causes for High ALT and AST in blood test?

I'm 25F and my blood test came back showing my ALT is 216 IU/L and my AST is 124 IU/L. I don't ever drink, I'm in a healthy weight, and I don't have preexisting conditions. However, i am pre-diabetic with my A1c being a 5.7. What could be causing my high ALT and AST? A year ago, it was at a 20. Could there be an error with the blood test?

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u/Due_Passage8349 — 1 day ago

Anxiety despite all clear

Hello everyone. Back in December, I got 2 fibroscans within 2 weeks of each other, and both showed Cirrhosis. Hepatologist ordered an MRI w/wo contrast and MR Elastography. The MRE showed 1.6 KPA, 7% fat in liver and 21cm liver. I was temporarily relieved. I was 342 ibs then. Currently I am 298 ibs. the health anxiety it has given me makes it very hard to get away thinking I still might have Cirrhosis. Now my palms get red and I scheduled another appointment with Hepatologist. My liver function tests have been very good (ALT and AST in the 20s). Has anyone dealt with so much anxiety despite getting good news?

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u/EldritchHarry — 1 day ago

Liver/gallbladder/digestive issues

Hi everyone,

I’ve been on a long 3 months of trying to figure out what is going on and just looking for stories of anyone who had anything similar.

I got 2 ct scans in march that showed an enlarged liver at 20cm, I saw a liver specialist and did a fibroscan which showed no fibrosis and all liver labs were normal and he said no follow up needed.

I had an ultrasound may 1 that showed the liver size as 15.2cm. No clarification on size difference from liver specialist as he said I shouldn’t be worried about the size when all other functions are normal.

I get RUQ and LUQ pains usually in the morning upon waking that prompts my lower stomach to cramp and then an urgency to have a bowel movement. My bowels have been soft but intact for the most part, some days there is an abundance of poop, it’s astonishing how much sometimes.

Over the last few days the RUQ and LUQ pains are brought on throughout the day from food, most notable is I had a iced chai for the first time in a long time and it started to ache, also I had a steak last night and it started up again.

They tested my stool for my pancreatic elastase enzynes april 28th and they were normal, they checked h pylori in march, and also calprotectin stool may 1st that was normal.

I am being referred to gi specialist now but they are booked until July.

Just seeing if anyone has had anything similar?

I have researched everything under the sun and seeing if this could be gallbladder dyskenesia, bile acid malabsorption, or anything in that ballpark of digestive issues?

Thank you!

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u/beachvibes007 — 3 days ago
▲ 7 r/LiverDisease+1 crossposts

I need a liver supplement as I refuse to stop drinking due to anxiety and pain in my heart

I am just wondering if any of you have tried the liver supplement Dose? I read a lot of reviews on Amazon and it seems like it’s the only one that lowers people‘s liver enzymes in lab test.

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u/SeaCupcake6031 — 7 days ago

Worried I have Hep C.

My brother is a former drug addict. He found out like a year and a half ago that he had Hep C.

He got treatment for it but we had no idea how long he had Hep C to begin with, and back then the two of us regularly shared nail clippers, hair clippers (we both used it with no guard if that makes a difference), etc.

I've been paranoid that I could have gotten Hep C from that but I'm too scared to get tested.

What are the chances of getting it from that? I think of all the times I've nicked myself while shaving with the hair clippers or nail clippers and worry that was enough to spread it if he did the same before I used them.

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u/frostmas — 5 days ago
▲ 10 r/LiverDisease+2 crossposts

Liver cancer metastasized . pleasee pleasee take a look into it🙏🙏🙏🙏🙏

My dad was recently diagnosed with cancer involving the liver. His CT report mentions multiple lesions in both lobes of the liver, enlarged lymph nodes, and metastasis. The biopsy confirmed cancer, but doctors still cannot identify the exact type or where it originated from, and we are currently waiting for the IHC report.

The local doctor told us that treatment options are limited to chemotherapy because it has already spread, and hearing that has completely devastated our family. My dad is only 50 years old and has worked incredibly hard his entire life, often 17 hours a day. Over a short period, he has lost nearly 20 kg, which has been heartbreaking to witness.

We are taking him to a larger cancer hospital for further evaluation and hoping for more answers and possible treatment options. Right now, I feel overwhelmed and scared. If anyone has experienced something similar, especially cases where the primary cancer was initially unknown or where patients responded well to treatment, I would truly appreciate hearing your stories or advice. We are holding onto hope while waiting for the IHC results.

( Normal in shape, size, attenuation & enhancement. Multiple heterogeneously enhancing lesions noted in both lobes of liver (more in left, largest measuring ~ 5.8x4.8 cm Hepatic veins and portal veins are normal. IHBR not dilated.) Left supraclavicular lymph node measuring ~ 27x14 mm.
Few subem left internal mammary lymph node noted
Few cardiophrenic lymph nodes noted, largest measuring ~ 19x11 mm.

IMPRESSION:
00.216 21
• Enlarged left supraclavicular lymph node.
• Few subem left internal mammary lymph node.
• Few cardiophrenic lymph nodes.
> Multiple heterogeneously enhancing lesions noted in both lobes of liver - likely metastatic (D/D : multifocal HCC).
* Mild pericholecystic fat stranding.
• Splenomegaly with Multiple splenorenal and splenogastric collaterals.
› Multiple aortocaval, paraaortic and periportal lymph nodes.
• Doubtful thickening in the region of cardia of stomach and GE junction. (Suggested upper Gl endoscopy to r/o gastric malignancy).
> Minimal perihepatic fluid.
› Small size left kidney with prominent pelvicalyceal system with slightly more enhancing parenchyma than right side - ? d/t previous intervention/? infectiye.

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u/Acrobatic_Winter9157 — 7 days ago

Constant pain an no one knows what it is

Hi, I’m 29 yrs old and I was diagnosed with fatty liver about 5yrs ago. About 2 years ago I was diagnosed with stage 2 liver fibrosis and since then I’ve been trying to get it under control unsuccessfully…

I’m writing here because since January I’ve been having really bad RUQ pain. I’ve gone to 3 different GI doctors, I’ve gotten an endoscopy, a colonoscopy, countless blood testing and a CT with oral contrast and 3 fibroscans, however everything is always normal, except for the fibrosis which keeps getting worse despite my dieting. When I tell doctors about my pain, they say that it shouldn’t be my liver and that it’s probably constipation even though I go to the bathroom regularly. They look at me like I’m crazy, even though I’m in constant pain and my RUQ is visibly inflamed. I’m starting to get worried that it could maybe be my pancreas or something more sinister. Has anyone ever dealt with something like this and could give me any tips? I just feel so lost and so alone.

Any help would be greatly appreciated.

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u/dlrs123 — 6 days ago

Can this be true

I have auto immune cirrhosis, my doctor started me on a new drug about 3 months ago. It was something I had to get mail order because none of the pharmacies carried it. Since then, I have had regular bm’s for the first time in my life, and although I have a drink maybe once a week, last time I went a little overboard and got drunk. That’s the first time in a year that I’ve been able to do that no matter how hard I tried (pre-diagnosis). Can this add up to “I am getting better?”

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u/Plenty_Surprise2593 — 7 days ago

NAFLD - Need help and tips!

Diagnosed with NAFLD recently, Age 31M. My fibroscan score showed 230 CAP and 9.4KPA. Doctor said it is at a stage somewhere between stage 2-3 fibrosis. ALT AND AST are 84 and 56, very much above normal levels. Conducted Hepatitis b and c tests, both negative. My current weight is 89kgs, and my ideal weight should be between 70-75kgs for my height. Any tips to get down to this? Post my diagnosis, I have cut all sweets, even diet coke. I have cut down alcohol and mostly eating salads with chicken, eggs etc, morning black coffee, gym, and if possible walk at nights. What else can I do to reverse my fibrosis as my doctor said it is still reversible. I am feeling very depressed as I have cut down added sugar completely and I have a sweet tooth. Even after all this my weight just wont go down and the visceral fat has stayed the same, mostly around my belly. For those who underwent a similar journey please help and share tips on what can I do. Thank you!

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u/Independentgene1508 — 8 days ago

Help my liver values are rising drastically quickly

Over the last few months my labs have been rising and I am completely at loss to what disease I have. I will need a liver biopsy but have a hemangioma.
Anyone had a liver biopsy with that? Also I do not drink nor take any medication. GI is referring me to hepatology. I am 36f with high cholesterol for years though. MRCP normal apart from showing enlarged liver. PSC and PBC and AIH are in the room. I have no IBD as far as I know. I am frightened specifically because they have sharply risen since I have given birth within half a year. They were normal apart from cholesterol.

AST / GOT: 54 U/L (Ref <35)
ALT / GPT: 281 U/L (Ref <35)
GGT: 309 U/L (Ref <38)
Alkalische Phosphatase / AP: 233 U/L (Ref 46–116)
Direktes Bilirubin: <0.3 mg/dL
Kreatinin: 0.66 mg/dL
eGFR: >60 mL/min
Autoimmune / Immunology:
ANA: <1:100 (negative)
AMA: <1:80 (negative)
anti-AMA-M2: negative
anti-LKM: <1:80 (negative)
anti-SLA: negative

Immunoglobulins:
IgG: 0.6 g/L
IgM: 0.91 g/L
IgG1: 5.88 g/L
IgG2: 2.50 g/L
IgG3: 0.13 g/L (low)
IgG4: 0.11 g/L

Virology:
Hepatitis C IgG: negative
Hepatitis E Virus IgG: negative
Hepatitis E Virus IgM: negative
HBs antigen: negative
Blood count:
Leukozyten: 6.0 G/L
Hämoglobin: 13.7 g/dL
Thrombozyten: 278 G/L

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u/DampierE_ — 10 days ago

Liver Enzyme’s and Weight Loss

Male 51.

I have always been a beer drinker and been overweight. I see my Dr every year and get my blood work done. For the last few years my ALT has been mildly elevated and my Dr has always told me it is due to fatty liver. A few years back I had high Bilirubin and they did an ultrasound and they mentioned fatty liver. During this time I was also diagnosed with Hasimotos disease. As well as a few other things that overweight people tend to have. Sleep apnea, mildly high cholesterol and blood pressure.
Well this January I found myself at 290 pounds and having a few beers by myself when my wife wasn’t at home. So the next day I contacted my PCP to discuss my weight and GLP medication. We started on it on Feb 15th. My regular check up a blood work were scheduled for April 15. I was looking forward to testing as I had lost 30 pounds at that point. Well, my ALT was up to 85 AST 53 and bilirubin of 1.6. As well my thyroid was way off as well. I was so disappointed as I had been cutting back on alcohol and had lost weight. The only good news is my Blood pressure was 120/80 and cholesterol is back to normal.
Sorry for the long story but if anyone else has a similar story or an idea of what is going on please let me know.

I go back to have another blood test soon so hopefully it doesn’t get worse.

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u/Poppyseedph — 10 days ago
▲ 5 r/LiverDisease+1 crossposts

Cirrhosis?

My 52 yo husband just stopped drinking 3 months ago after his second round of medical detox. He’s convinced he’s not got cirrhosis because he’s stopped drinking. He won’t go to the doctor but has diarrhea at least once daily and lost about 60 pounds in the months before he quit drinking - maybe 10 more afterward. In detox the last time they told him he had mild pancreatitis. The didn’t treat him there for it. He has itchy skin and hardly sleeps. He eats so much sugar like powdered donuts, candy bars, ice cream etc. Even with the weight loss he has a belly. He won’t go to a doctor except he wants to see a psych to see if he has ADHD because he has racing thoughts. He goes to the gym every day and says he feels fine but less coordinated than usual. He also has really bad shoulder pain sometimes. Are these not all signed of liver damage? Has anyone here had to convince someone to see a Dr for this? Before he quit drinking he drank 10-24 shots of vodka daily for at least 8 years, probably more before we met.

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u/TreeComfortable770 — 12 days ago

High AST and ALT (can cause feeling off?)

Hi y’all, I have high AST (90) and ALT (251) from my last blood test. I went to the doctors today to get it rechecked and should be getting the blood test results back soon.

I have a question, I’ve been feeling off for the past 1-2 months. Brain fog, not feeling in my own energy, not feeling like myself, reduced mental clarity, reduced memory and recall.

Could this be likely because of something correlated with what’s causing the ALT and AST levels to be high? I’m waiting for the blood test to come back from my doctor for the second time and will go through the treatment plan (liver ultrasound and diet changes if necessary), but want to see if my feeling off can plausibly and likely be attributed to what’s causing my liver enzymes to be high.

I’ve been pretty worried about why I’ve been feeling off the past 2 months, and just finally think I might’ve found the cause today. Would appreciate any thoughts

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u/CuriousOpening5048 — 10 days ago

Scarily elevated AST, ALT, ferritin

25F. 220 lbs 5’7. History of hEDS, MCAS, POTS.

My bloodwork last week came back as 807H for Ferritin, 50H % Saturation, 344 AST and 216 ALT. All my other labs were pretty normal. I am a moderate drinker but this bloodwork did come after a week of heavy drinking (law school graduation lol). I am really concerned and am wondering what to do/potential causes.

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u/Wise-Unit-6735 — 11 days ago

Significant spleen and liver enlargement

On ultrasound - liver 25.2cm, spleen 17.7cm, portal vein is patent with hepatopetal flow.
On labs - AST - 45, ALT - 70, bilirubin, Alk Phos all normal
I am obese, middle-aged, non-drinker, non-smoker who has had mildly elevated AST/ALT for years. I am actively trying to lose weight, but it is very slow going.
For some reason, when my primary got my ultrasound, she sent me to a cancer clinic. They told me that my liver couldn't be causing such spleen enlargement when my labs aren't showing a high level of liver involvment. They have run a bunch of tests (& are ordering a bone marrow biopsy)) and have also sent me to a gastroenterologist who is also running tests. The gastro dr took one look at me and said it was probably fatty liver - & he disagreed with the cancer people on whether or not the enlargement could be do to severe liver disease with mostly normal labs. I am putting the bone marrow biopsy on hold b/c that seems a bit overkill when other cancer labs seem normal. Gastro is taking a bunch of blood tests. Tried a fibroscan but they couldn't get consistent results b/c of my weight. I don't know what his next thing will be (though I did notice he ordered NASH fibrosure plus, Enhanced liver fibrosis, and fib-4 with reflex to ELF labs).
I'd love to hear your experience if you have had a similar situation. Could my significant spleen enlargement be due to fatty liver that isn't cirrhosis?

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u/highdesertwind — 11 days ago

Hi everyone.

I was wondering how everyone has gotten their diagnosis of hepatomegaly and how you have been screened after to check on progress?

I received a ct scan 3/18/26 with the liver coming back at 20cm craniocaudal of right hepatic lobe, and an ultrasound 5/4/26 that said 15.2cm in length.
That seems like a big size discrepancy, the doctors are looking into this but I wanted to see if anyone has had ultrasounds as routine check ups on their liver?

Thank you!

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u/beachvibes007 — 14 days ago