r/MycoplasmaGenitalium

I’ve tested positive for Mycoplasma genitalium twice and wanted to get a resistance test before starting antibiotics.

The lab used the same urine sample that had tested positive for Mgen. Now they’re saying the resistance test was negative because there wasn’t enough bacteria to reliably determine resistance, and they want me to submit another sample in two weeks.

I’m confused because it’s the same sample that was positive before. I understand that a low bacterial load can make resistance testing difficult, but this still seems weird to me.
Has anyone experienced this? Is this a normal limitation of Mgen resistance testing?

Hello all,

Any other women here develop a yeast infection after being cured of Mgen that is incredibly stubborn?

I’ve done
Twice - 3 day flucanazole prescription
Once - 1 day tioconazole over the counter.

Prior to Mgen I was not someone who got yeast infections often.

Things I already do: probiotics, candida support supplement, and my diet has almost zero sugar and very low carb.

Hi everyone hoping for some advice or encouragement IDK :(

I tested positive on 5th June after a problematic period, I’ve been married 6 years and we both are very loyal. My husband’s test was negative. I had 7 days doxi, followed by 3 days azithromycin. Hubby never got any treatment as they said no need!!! I had my TOC beginning Aug, found out today I’m still positive and hubby is still negative. Dr said on the phone I have to see him on Thursday in the surgery and the next steps is Moxifloxacin.

What questions should I be asking on Thursday? Is this treatment suitable? What is the chances of it working?

We have been trying for a baby last 3 years and even our fertility team didn’t test for this, they just passed me over to IVF. Im wondering how long I’ve had it, how much damage is done? Will I ever be able to have a baby? Is IVF now also not possible?

Heartbroken, let down and confused x

did anyone else still experience pelvic pain still even after completing doxycycline? ig i had mgen for months without knowing/ being misdiagnosed w UTI & kidney disease but i’m finally on my 3rd dose of antibiotics after completing azithromycin(which cured my ureaplasma) and i just finished my doxycycline but now im on my first day of taking moxyfloxacin & im still experiencing pelvic pain. i’m seeing a urologist the end of this month & that’s the only symptom im experiencing. any tips or advice ? tysm

For example, if I take my last dose of doxycycline at around 2–3 PM, when should I take my first dose of moxifloxacin? Would you start moxifloxacin later that same day, or wait until the next day?

Got mgen back I. July I took doxi & moxi waiting to get my TOC but even if worst case scenario I test postive my infection doctor did speak about nuzyra with me. I’m curious to see if anyone had any good news with this antibiotic

Hi all! There’s not a lot of information on mycoplasma Hominis so I’m posting here again to get some clarity.

I was prescribed 2 weeks of doxycycline by my gynecologist and I am not sure if the treatment really worked. I know residual symptoms are common but I can tell the difference between residual symptoms and symptoms after when a treatment doesn’t work. (I’ve had UU in the past so I’ve had experience with both).

There are some studies that show mh is naturally resistant to macrolides such as z-pack & clarithomycin.

I’ve found some studies/posts that show success with clindamycin. I’m going to make an appointment with Sarah Weld (she’s been recommended on Ureaplasma subreddit) if you know anyone in NY who’s well versed for plasmas, please let me know.

I’ve been seeing neena agrawala who’s been very helpful but doesn’t seem to know a lot about the treatments for these strains. I would really appreciate any insight from the mods or people on here what treatment would be the best for mh? I’m going to ask for clindamycin next if this test comes out positive. I know moxi is also a recommended treatment for mh. I’m still waiting a couple of weeks to get tested because I don’t want to get a false positive or negative.

again, any insight could be helpful! I’ve been dealing with this for a while and it’s taking a toll on my mental health

Shortly after a sexual encounter, I developed **constant urethral discharge** that I had never experienced before. Around the same time, I had some **balanitis-like symptoms** — irritation/sensitivity around the tip, with occasional mild itching/redness.
The woman I was having sex with was also dealing with **bacterial vaginosis (BV)** around this period and had a noticeable fishy odor. We had sex within that timeframe, and my symptoms appeared shortly afterward. I don’t know if the BV is related, but I figured it was important context.
Over time, I also developed urethral tingling/irritation, a frequent or almost constant urinary sensation, and some groin/pelvic discomfort.
The confusing part is that **everything keeps coming back normal or negative**. Standard STI tests have been negative, and a routine bacterial urine culture showed no growth. Initially, my urine did show leukocytes/inflammation, but that decreased significantly on later testing.
I’ve taken antibiotics, and the symptoms improved while I was taking them. The constant discharge decreased significantly and eventually became something I mainly noticed **after urinating**. After being off antibiotics, though, the symptoms have returned and feel much closer to how they were at the beginning.
I’m currently waiting on broader testing for organisms that aren’t always included on standard STI panels, and I’m also doing broader molecular/NGS testing.
**Has anyone developed persistent urethritis after sex with a partner who had BV, while all the usual STI tests and urine cultures stayed negative?** Did further testing eventually identify **Mgen, Trichomonas, Gardnerella/BV-associated bacteria, another organism**, or did everything continue to test negative?
If you eventually figured it out, **what test finally found the cause and what was your diagnosis?** Mainly interested in experiences from people who actually went through something similar.

so in total 200 mg of sitafloxacin plus 200mg of Doxycline for 14 days

I’m worried about getting floxed. but since I failed Minocyline I guess i have to try something else.

has anyone else been prescribed this dosage before? is this too much?

My Obgyn recommended after taking my antibiotics that I starting taking probiotics and multivitamins. Did most of you get the same advice ? Any recs for those ?

I’m really sorry if this has been asked before, but I’m honestly very anxious about this and would appreciate some reassurance.

I had already taken doxycycline previously, and my ID prescribed moxifloxacin for my Mgen without repeating the doxycycline. Unfortunately, I got scared and overthought my treatment, so I took doxycycline again on my own before starting the moxifloxacin, even though I had already taken doxy before.

I know I should have followed my ID's instructions, and I’m really sorry that I didn’t. Now I’m scared that by taking doxycycline again, I may have put additional selection pressure on the Mgen or somehow made it more resistant, especially to moxifloxacin.

Could taking doxycycline again lower the chance that my moxifloxacin will cure the Mgen? Could I have somehow made the bacteria harder to treat?

I took cipro years ago while unknowingly positive for mgen. How likely is it that it will be resistant to moxy? Its already resistant to macrolides and I cant get the flouroqyinolone restant test.

I wanted to share my experience because I was convinced I had messed up my treatment.

I tested positive for MGen and BV. I was prescribed doxycycline for 7 days, moxifloxacin for 7 days, and metronidazole for the BV. I misunderstood the instructions and took all three medications during the SAME 7 days instead of taking the doxy first and then the moxi.

I later learned that doxy followed by moxi is the recommended sequence, so I was worried my treatment had failed.

Well, I just got retested about 2 months later and my MGen is NEGATIVE! 🎉 I also had no sexual contact between treatment and retesting, so there was no possibility of reinfection during that time.

Obviously I’m not recommending anyone copy what I did. That week was brutal. I wish I’d known about taking probiotics to help my gut.

Follow your doctor’s treatment instructions. I just wanted to share my experience for anyone who accidentally took doxy and moxi concurrently like I did and is freaking out wondering if they ruined their chances of clearing it.

she prescribed me moxy despite my glute medius tear.. and she wouldn’t budge. i know it isn’t a tendon but i rather not risk it.

i tried getting a prescription thru amazon medical but my dumbass mentioned that she prescribed me moxy when i should of just pretended she didn’t give me anything lol, the np was nice but didn’t wanna go against what she prescribed.

i’m desperate at this point, is it possible to get prescribed thru goodrx if i lie and say it’s for acne mayhaps? scared if i do video call they’ll just point out that my skin’s clear.

also: should i still take 7 days doxy beforehand if they’re in the same antibiotic class?

edit: thank you all for the advice!! just sent an order thru telyrx, waiting on getting the rx approved

Where can I get an at home test for my female partner that will test for mgen and uu? I am having trouble finding one that will do both.

I recently tested positive for mgen and was treated with 7 days of doxy and 7 days of moxi

My partner told me that when he had it previously, he cleared it with just doxycycline, so I believed that he was clear. We both took our own different medication and eventually started having sex again. About a month or so after I finished my treatment, we had sex again, but neither of us ever actually got retested/tested for cure afterward.

Now he says he tested positive for mycoplasma hominis after our recent time together? and I’m freaking out a little because I have no idea whether I was reinfected, whether he never cleared the original infection, or whether these are two separate issues.

The other complication is that I dont have health insurance right now and it could be a while before its reinstated. so my options are limited right now. I’m in NYC and know I can go to the city/state sexual health clinics, but I’m wondering whether they’re experienced with more complicated Mgen cases, especially since I’ve already done doxycycline + moxifloxacin and don’t want to just keep taking antibiotics without knowing what I’m treating.

Has anyone dealt with Mgen after already completing doxy + moxi, especially when neither partner got retested before having sex again? What did your doctor do next? Did they do resistance testing or send you to an infectious disease/STI specialist?

I’m also wondering about treatment options outside the U.S. if this turns out to be resistant. I’ve considered going to France and seeing a doctor there/getting a prescription filled there if there are treatment or resistance-testing options that aren’t easily accessible in the U.S., but I have no idea whether that would actually make sense.

I’m obviously going to get tested before taking anything else. I’m mainly looking for experiences from people who’ve been through a similar situation and what type of clinic/specialist you ended up seeing.

Located in USA and did not have resistance testing! Thank you to this page and God :)

No one talking about this std and how fast is spreading , I got infected in march 2026 took me almost 4 months to get ride of it , my friend tested positive two weeks ago after one exposure, literally he hooked up with this girl for one time .. I think mgen is more common now than chlamydia .. it’s very scary and this stubborn bacteria is building resistance very fast to many antibiotics now .
Sexual clinics are not testing for it , most doctors don’t know anything about it . Crazy

i had been dealing with symptoms of mgen and ureaplasma parvum since february 2026. my male partner and i took azithromycin and doxycycline. i didn’t know you were supposed to test 4-5 weeks after your last antibiotic pill. i tested negative 3 weeks after my first. he never received a test of cure with us believing if i was negative he was i learned that doesn’t matter. so now we had unprotected sex last week that resulted in me being very inflamed and red afterward. now almost a week later im having pelvic pain. im already scheduled to see my doctor on thursday. i feel so discouraged and anxious because i truly thought i was done.