
Spudcell and the definition of `Life`
In 2004, Danish physicist Steen Rasmussen attempted to create life in a laboratory starting from non-living precursor chemicals. While his lab used PNA (peptide nucleic acid) as a storage for genetic information, they were unsuccessful in their endeavors. Rasmussen reported to the press that they were unable to get "one freaking life cycle". Rasmussen described his work as a vicious chicken-and-egg problem. The enzymes required to replicate DNA are themselves encoded in DNA.
In June of 2026, researchers at University of Minnesota got one freaking life cycle in a synthetic bacterium. Spudcell completes a life cycle and makes a copy of itself. After many generations, the researchers observed selection of certain attributes. In other words, Spudcell was evolving.
Questions remain, however. Spudcell is unable to feed itself and requires outside help by humans. After 10 generations, Spudcell cultures deteriorate. The reasons are related to ribosomal structures, which Spudcell can't autonomously maintain. In the early 2000s, researchers assumed that genetic information + metabolism is all that is needed in a functionining living organism. But Spudcell's failures highlight missing ingredients in that formalism. At this juncture, we must update our pre-existing definition of "life" and once again redefine what we mean when we say that some collection of matter is "alive."