Alright! I’ve got about 7 peptides that I picked up and started testing around two months ago. I’ve been slowly adding them in so I can write reports on them and actually know what’s doing what. I’ll make another post on all the peptides I’m testing, but for this one specifically, we’re talking about DSIP.

If I had to describe my experience so far in one sentence, it’s this: it’s like Inception in a bottle. You have dreams that are three layers deep lol. They’re the most vivid dreams possible. I’ve had a couple lucid dreams, and when you wake up, you’re like, holy shit… was that real or was that a dream? I cannot express enough how crazy my dreams have been.

I’ve definitely noticed I feel a lot more well-rested when I wake up. I read a lot about this peptide before taking it and did a ton of research, and what I found was people were starting way too low/not feeling anything. And for something like this, I just said screw it and went out of the gate at 500 mcg daily. The “starting point” is supposed to be 100–300 mcg, but I personally didn’t want to go through that and wait, so I jumped in at 500 mcg—and that was perfect.

I’ve now been on it for about three weeks, still at the same dose, and it’s still just as effective, so there hasn’t been any need to increase it. I’m not gonna lie—I did bump it one day just for shits and giggles up to 750 mcg, and honestly that dream was a little too real, so I backed down to 500 mcg lol.

And let me tell you, it’s nothing like melatonin. I absolutely hate melatonin. Every time I take it, it doesn’t make me sleepy, but I’ll fall asleep for three hours and then I’m wide awake the rest of the night. Worst sleep aid for me personally.

So far, ranking my favorite lifestyle peptides:
#1 Reta, #2 Melanotan-2, #3 DSIP.
I’m obsessed with sleep. I think it’s the most underrated thing in today’s world. With all the biohacking and grind mindset, everybody thinks they need to work insane hours and sleep five hours, which makes zero sense. My entire day is ruined if I don’t get at least six hours.

So all in all, I’d say this one is worth giving a shot—pun intended. I’m curious: if you’ve run this peptide before, what was your experience? And did you start with 100 mcg, or were you aggressive with it like me and jumped to 500 mcg?

Let me know in the comments below.

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I want to make sure the content here actually serves you, so I'm opening it up: what do you want to see more of? Deeper compound breakdowns, protocol guides, research news, experience/log threads, vendor reviews, beginner resources, Q&A formats?

Drop it in the comments. I read everything and the most requested topics will drive what gets posted next.

Reconstitution questions come up constantly in the comments and I keep seeing people guessing at the numbers. So here's a follow up to the DIY nasal spray guide with the exact math for every compound, every vial size — how much water goes in the vial, how much goes in the bottle, and what dose you're getting per spray. No more guessing.

A lot of people mess up peptide math because they’re trying to calculate mg per vial, total liquid volume, mcg per spray, or units on an insulin syringe all at once.

So I made a simple calculator for it.

You enter:

mg per vial
how much liquid you’re adding
target dose
spray bottle size / sprays per bottle
or syringe units

And it does the math for you. Just click the Intranasal tab.

Here’s the calculator: DIY Nasal Spray Calculator

The Formula

Vial mode — how much liquid to add:

mL to add = (Mass in vial [mg] × 1000) ÷ Desired dose [mcg] × Volume per spray [mL]

What Water Should You Use?

Before anything else, you need to pick your diluent. This is the liquid you use to dissolve the peptide powder and fill your spray bottle. There are four main options and each has its tradeoffs.

Diluent Options

Sterile Water — no preservative, 5–7 days refrigerated. Fine for short runs.

Saline (0.9% sodium chloride) — more comfortable in the nose, no preservative. Shelf life is generally quoted at 14–21 days. I personally have used saline for up to 31 days with no issues — just my experience before too many of you start asking. Solid option for most peps since you'll go through it quickly anyway.

BAC Water — 0.9% benzyl alcohol preservative, 28–30 days refrigerated. Most common choice. Some find it mildly irritating in the nose over time.

BAC Water + Saline Mix (recommended if you want more sterility) — best of both worlds. 28–30 day shelf life with better nasal comfort than straight BAC water. Only downside is comfort. To make it:

1. Add your reconstituted peptide solution (2 mL from the vial) to the spray bottle first
2. For the remaining volume, split it 50/50 — half BAC water, half saline. So if you need 3 more mL, add 1.5 mL BAC water + 1.5 mL saline
3. Swirl to mix

Two-Step Protocol

Step 1: Add 2 mL of diluent to the peptide vial. Swirl gently until dissolved — never shake.

Step 2: Draw the 2 mL into a syringe, inject into your nasal spray bottle, then top up with remaining diluent to hit your target volume. Swirl to mix.

Reconstitution Steps

1. Let vial reach room temp
2. Draw 2 mL of diluent into syringe
3. Insert needle, angle so liquid runs slowly down the side of the glass — not directly onto the powder
4. Swirl gently until dissolved — never shake
5. Draw the full solution into syringe, inject into spray bottle
6. Add remaining diluent to spray bottle to hit target volume, swirl to mix
7. Label: compound, date, concentration, diluent
8. Refrigerate immediately at 2–8°C

DIY Nasal Spray Peptides

Semax

Cognitive / BDNF | Full dose per nostril each session

5 mg vial

Low — 100 mcg/nostril (200 mcg total)

• Add 2 mL to vial, transfer to bottle, add 3 mL to bottle
• 5 mL total | 1,000 mcg/mL | 25 doses

Standard — 250 mcg/nostril (500 mcg total)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 2,500 mcg/mL | 10 doses

High — 500 mcg/nostril (1,000 mcg total)

• Add 1 mL to vial, transfer to bottle, no additional liquid needed
• 1 mL total | 5,000 mcg/mL | 5 doses

10 mg vial

Low — 100 mcg/nostril (200 mcg total)

• Add 2 mL to vial, transfer to bottle, add 8 mL to bottle
• 10 mL total | 1,000 mcg/mL | 50 doses

Standard — 250 mcg/nostril (500 mcg total)

• Add 2 mL to vial, transfer to bottle, add 2 mL to bottle
• 4 mL total | 2,500 mcg/mL | 20 doses

High — 500 mcg/nostril (1,000 mcg total)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 5,000 mcg/mL | 10 doses

Selank

Anxiolytic / GABAergic | Full dose per nostril each session

5 mg vial

Low — 100 mcg/nostril (200 mcg total)

• Add 2 mL to vial, transfer to bottle, add 3 mL to bottle
• 5 mL total | 1,000 mcg/mL | 25 doses

Standard — 250 mcg/nostril (500 mcg total)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 2,500 mcg/mL | 10 doses

10 mg vial

Low — 100 mcg/nostril (200 mcg total)

• Add 2 mL to vial, transfer to bottle, add 8 mL to bottle
• 10 mL total | 1,000 mcg/mL | 50 doses

Standard — 250 mcg/nostril (500 mcg total)

• Add 2 mL to vial, transfer to bottle, add 2 mL to bottle
• 4 mL total | 2,500 mcg/mL | 20 doses

High — 500 mcg/nostril (1,000 mcg total)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 5,000 mcg/mL | 10 doses

Adamax

Cognitive / nootropic blend | 10 mg vial | Dose split between nostrils

Standard — 200 mcg total (100 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 3 mL to bottle
• 5 mL total | 2,000 mcg/mL | 25 doses

High — 300 mcg total (150 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 1.33 mL to bottle
• 3.33 mL total | 3,000 mcg/mL | 16 doses

Melanotan II

Tanning / libido | 10 mg vial | Dose split between nostrils

Loading — 500 mcg total (250 mcg/nostril) daily until pigmentation achieved

• Add 2 mL to vial, transfer to bottle, add 2 mL to bottle
• 4 mL total | 2,500 mcg/mL | 20 doses

Maintenance — 250 mcg total (125 mcg/nostril) 2–3x per week

• Add 2 mL to vial, transfer to bottle, add 6 mL to bottle
• 8 mL total | 1,250 mcg/mL | 40 doses

PT-141 (Bremelanotide)

Sexual health / MC4R agonist | 10 mg vial | Dose split between nostrils

Low — 500 mcg total (250 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 2 mL to bottle
• 4 mL total | 2,500 mcg/mL | 20 doses

Standard — 1,000 mcg total (500 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 5,000 mcg/mL | 10 doses

High — 2,000 mcg total (1,000 mcg/nostril)

• Add 1 mL to vial, transfer to bottle, no additional liquid needed
• 1 mL total | 10,000 mcg/mL | 5 doses

Dihexa

Cognitive / HGF agonist | 10 mg vial | Dose split between nostrils

Low — 50 mcg total (25 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 18 mL to bottle
• 20 mL total | 500 mcg/mL | 100 doses

Standard — 100 mcg total (50 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 8 mL to bottle
• 10 mL total | 1,000 mcg/mL | 50 doses

High — 200 mcg total (100 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, add 3 mL to bottle
• 5 mL total | 2,000 mcg/mL | 25 doses

BPC-157

Anti-inflammatory / gut healing | 5 mg vial | Dose split between nostrils

Low — 250 mcg total (125 mcg/nostril)

• Add 2 mL to vial, transfer to bottle, no additional liquid needed
• 2 mL total | 2,500 mcg/mL | 10 doses

Standard — 500 mcg total (250 mcg/nostril)

• Add 1 mL to vial, transfer to bottle, no additional liquid needed
• 1 mL total | 5,000 mcg/mL | 5 doses

Intranasal works for systemic and gut effects. SubQ or IM preferred for localized injuries.

Semax + Selank Blend

A lot of people run these two together in a single spray bottle. The math is straightforward — you reconstitute each vial separately with 2 mL, then combine both into one bottle. Each spray then delivers both peptides simultaneously at whatever concentration you mixed to.

Since both Semax and Selank are dosed at full amount per nostril, the blend works the same way — one spray per nostril per dose.

Both 5 mg vials (10 mg total peptide)

Low blend — 100 mcg Semax + 100 mcg Selank per nostril (200 mcg each per dose)

• Reconstitute Semax 5 mg with 2 mL, reconstitute Selank 5 mg with 2 mL
• Combine both into one spray bottle, then add 6 mL to bottle
• 10 mL total | Semax 500 mcg/mL | Selank 500 mcg/mL | 100 sprays = 50 doses

Standard blend — 250 mcg Semax + 250 mcg Selank per nostril (500 mcg each per dose)

• Reconstitute Semax 5 mg with 2 mL, reconstitute Selank 5 mg with 2 mL
• Combine both into one spray bottle — no additional liquid needed
• 4 mL total | Semax 1,250 mcg/mL | Selank 1,250 mcg/mL | 20 sprays = 10 doses

Both 10 mg vials (20 mg total peptide)

Low blend — 100 mcg Semax + 100 mcg Selank per nostril (200 mcg each per dose)

• Reconstitute Semax 10 mg with 2 mL, reconstitute Selank 10 mg with 2 mL
• Combine both into one spray bottle, then add 16 mL to bottle
• 20 mL total | Semax 1,000 mcg/mL | Selank 1,000 mcg/mL | 200 sprays = 100 doses

Standard blend — 250 mcg Semax + 250 mcg Selank per nostril (500 mcg each per dose)

• Reconstitute Semax 10 mg with 2 mL, reconstitute Selank 10 mg with 2 mL
• Combine both into one spray bottle, then add 4 mL to bottle
• 8 mL total | Semax 2,500 mcg/mL | Selank 2,500 mcg/mL | 80 sprays = 40 doses

High blend — 500 mcg Semax + 500 mcg Selank per nostril (1,000 mcg each per dose)

• Reconstitute Semax 10 mg with 2 mL, reconstitute Selank 10 mg with 2 mL
• Combine both into one spray bottle — no additional liquid needed
• 4 mL total | Semax 2,500 mcg/mL | Selank 2,500 mcg/mL | 40 sprays = 20 doses

Storage

Dry powder — refrigerator 6-12 months, freezer 12–24+ months

Reconstituted with BAC water or BAC + saline mix — 28–30 days refrigerated

Reconstituted with saline — 14–21 days refrigerated

Reconstituted with sterile water — 5-7 days refrigerated

Keep away from light and heat. Only freeze non-reconstituted powder.

Hope this helps! Please comment below if you have more questions about the math you are trying to figure out or if you need extra help.

Kind of new to the group. Can any one DM good Chinese or US sources? I'm here because of a partially torn labrum I've been dealing with for 8 months.

Ive done PT to no avail. Its either PRP at $600 a session or peptides? Modern medicine is a failing at this point. PRP has limited success with labrum tears.

The two tears are not off the bone. Any help would be greatly appreciated. Thanks in advance for your time.

Obviously looking for BPC-157 & TB-500 solutions. Sincere thanks for any and all help. Just trying not to be in chronic pain.