
r/neurobiology

Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD | Apr 2026
science.orgYour brain may keep learning even when you are unconscious
Scientists recently recorded neural activity in the hippocampus of seven patients under general anesthesia and found something strange: the brain was not just passively hearing sounds. It was still learning patterns. In one experiment, hippocampal neurons became better at detecting unusual tones among repeated sounds over just a few minutes.
In another experiment, patients under anesthesia listened to speech. Their hippocampal neurons responded to word frequency, parts of speech, and semantic categories, and even carried information about what kind of word might come next in a sentence.
Clearly, nobody is learning a new language while knocked out, but the takeaway is clear: even when consciousness is completely switched off, the brain keeps mapping out the outside world.
Why motivation always dies after 3 days — the actual neuroscience (not the motivational speech version)
I used to think I just had bad willpower. Every time I started something new, I'd be fully in it for about 3 days — then nothing. The drive would just disappear. No reason. No event. Just gone.
Turns out there's a specific mechanism for this. It's called the dopamine prediction error, and it was documented by neuroscientist Wolfram Schultz in the 1990s.
Here's the short version:
Dopamine isn't the "pleasure" chemical — it's the anticipation chemical. It fires BEFORE you get a reward, not during it. When you start a new goal, your brain spikes dopamine based on imagining the result. That's the Day 1 energy.
But here's what happens next: every day the result doesn't arrive, your brain updates its prediction model downward. By Day 4, the spike has degraded. The goal no longer triggers the same anticipation response.
So you didn't "lose motivation." Your dopamine prediction system ran its default program.
The second layer is worse: something called the Behavioral Inhibition System (BIS) activates whenever your brain detects a mismatch between what you expected (effortless progress) and what you're experiencing (slow, uncomfortable work). The BIS produces anxiety — and makes the alternative (scrolling, resting, doing nothing) feel like RELIEF. Like the right choice.
Your brain isn't broken. It's running ancient software designed for immediate feedback (hunt → eat or don't). It was not designed to sustain motivation for a goal you'll achieve in 6 months.
What actually works (the 3 systems that bypass this):
Identity-based framing: "I want to exercise" breaks down fast. "I am someone who moves every day" bypasses the BIS because there's no mismatch to detect. The action confirms the identity.
Process rewards: Your brain sustains dopamine when it learns to anticipate the process, not just the result. This is why habit trackers and streaks work — you're training the anticipation system to fire on the action itself.
Friction reduction: Stanford research found motivation rarely fails from lack of desire — it fails when the friction of starting exceeds the motivation available at that moment. Put the shoes out. Open the app. Have the notebook ready. Engineer the first 60 seconds to require zero decisions.
The difference between people who sustain motivation and people who don't isn't willpower. It's whether they understand the system they're working with.
Happy to answer questions — I went deep on this topic recently and made a full breakdown if anyone wants the complete version with all the sources.
Map of Brain Histamine System Links Molecule to ADHD and Depression
neurosciencenews.comWeek 1 Progress Report : Experiment Neuroplasticity
Its been a nearly Successful one week of this experiment and I'd like to that I am proud of myself for not completely giving up even in this short duration. and i have already started to feel better and less anxious.
although there were a few moments of sneak peeking but I guess its a good progress for a beginner level.
I am not chasing 100% efficiency from the very first day, the Idea is to build gradually and stack up consistently, and along the way build some proof of my commitment to train my subconscious into becoming a new person, or as wee said in the start "REWIRE THE BRAIN"
And posting here is an extremely integral part as it motivates me to not fail in front of everyone and anyone who is looking up at me here.
Day 07 stats:
- Phone Usage: 3h 2m
- No Junk food and shortform consumption
- practiced deliberate boredom for 20 minutes
if you are thinking about starting a similar detox journey or escape the scroll, Start today bro.
How the brain switches between older and newer memories
medicalxpress.comThe human brain processes the passage of time across three distinct stages
psypost.orgSays in India, Art Deco is architecture of the common man (as compared to displays of power in America) vs. neo-Gothic/neo-Classical structures
Also says that the rise of gated communities, the lack of integration with Navi Mumbai is hurting Mumbai's growth. Explains why it's impossible for India to create it's own national architectural style
Thoughts?
What process in the brain allows us to participate in the moment:
\*\*\*"More likely, we will take experience itself as a fundamental feature of the world, alongside mass, charge,and space-time. If we take experience as fundamental, then we can go about the business of constructing a theory of experience."\*\*\*
D.J. Chalmers 1995
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Neuroscience has a pretty good idea of how long-term memories are created and stored in the brain (\[Donald Hebb\](https://en.wikipedia.org/wiki/Donald\\\_O.\\\_Hebb)'s Fire together/Wire together), but this process involves actual growth of interconnections in the brain and takes days to weeks to complete. Learning to play a passage on the piano is this type of learning.
Short-term or working memory is being studied, but there doesn't seem to be an agreement on the mechanical apparatus that does the work. Remembering a list of numbers read to you five minutes ago is an example of this type of learning.
I want to understand the processes that allow us to be aware of our surroundings in the tens of milliseconds time frame. No one seems to have an idea on this, or at least I haven't run across it yet. Needless to say - its complex. .
Along the way, I wanted to present what I have found in a format that is accessible to others like myself - interested in the subject but not expert in it. I decided publish my learning process as well in near real time and this web site is the result. It will be continuously updated as I work on the project.
Joscha Bach: Why Mind Uploading Probably Won't Work
Plasticity and language in the anaesthetized human hippocampus
nature.comScientists Map Thousands of Brain Connections With RNA Barcodes
scitechdaily.comScientists show how common chord progressions unlock social bonding in the brain
psypost.orgCan humans count at 2 different frequencies
I am just wondering whether is biologically possible for humans to count 2 different things at different frequencies. for example counting your heartbeat and time together ??
Scientist solves the biological function of REM sleep
The biological function of REM sleep remains one of the great mysteries of neuroscience. Most of neuroscientists have long assumed it’s about memory consolidation or emotional processing. But a recent paper proposes another explanation. The paper in question was published in Sleep Medicine X.
The author proposes that REM sleep evolved as a sentinel mechanism. His key argument is that the Sentinel Sleep Theory resolves the paradox of why we spend so much time in a state that looks like wakefulness but keeps us paralyzed.
I’d love to hear your thoughts on this research.