r/peptidebenchmark

A quick warning to anyone considering joining "The Peptide Plug": save yourself the headache. While their initial pricing seems appealing, the excessive wait times and operational chaos completely negate any potential savings. Their standard practice is a bait-and-switch—advertising one vendor, secretly fulfilling with another, and then blaming the new vendor when quality issues arise.

Furthermore, there is zero tolerance for feedback; raising a legitimate concern will just get you banned. To top it off, the group owner, Shawn, openly flaunts the free perks he receives while members are left dealing with the problems.

During a recent group buy they discovered that some of the product was fake and the admins fulfilled their orders with what was good before shipping the fake stuff to the members

I wish there was a way for me to attach the most recent communication from one of the groups minions

Lilly presented TRIUMPH-2 at EASD (a big European diabetes conference) on Tuesday, and the full paper went up in The Lancet the same day. This trial looked at people who have both type 2 diabetes and obesity, so it's the first big look at how reta does in diabetics. I read through it, and the headline number (20.8%) is honestly the least interesting part.

Quick background

Retatrutide is a weekly injection from Lilly. Sema (Ozempic) targets one gut hormone receptor (GLP-1), and tirz (Mounjaro) targets two (GLP-1 and GIP). Reta targets three, adding glucagon. The idea is that the extra one helps you burn more energy, not just eat less.

The setup

• 1,152 people
• 80 weeks (about 18 months)
• Four groups: 4 mg, 9 mg, 12 mg, or placebo (a dummy shot)
• Everyone on the real drug started at 2 mg and moved up every 4 weeks until they hit their dose, which helps with side effects

Weight loss

Average % of body weight lost over the 80 weeks.

• 4 mg: 12.7% (~30 lbs)
• 9 mg: 19.1% (~45 lbs)
• 12 mg: 20.8% (~50 lbs)
• placebo: 4.0% (~9 lbs)
• 12 mg, people with a BMI of 35+ only: 23.4% (~61 lbs)

Going from 4 to 9 mg adds about 6 points of weight loss. Going from 9 to 12 adds less than 2. In other words, most of the benefit is already there at 9 mg.

A1C (blood sugar)

A1C is your average blood sugar over the last ~3 months. Under 5.7 is normal, 5.7 to 6.4 is prediabetes, and 6.5+ is diabetes. A drop of 1 point is considered a big deal.

• 4 mg: dropped 1.4 points
• 9 mg: dropped 1.6
• 12 mg: dropped 1.5
• placebo: dropped 0.2
• Up to 40% of people got all the way down to the normal range (under 5.7)
• Up to 79% got out of the diabetes range (6.5 or below)

9 mg and 12 mg are basically identical here. If blood sugar is what you care about, the higher dose isn't buying you anything.

Dropouts

The % of people who quit the trial because of side effects. It's a good real-world gauge of how tolerable a drug is.

• 4 mg: 3.8%
• 9 mg: 11.6%
• 12 mg: 7.7%
• placebo: 4.9%

This is the weird one. You'd expect more people to quit as the dose goes up, but 9 mg had the most dropouts, more than 12 mg. It could just be random chance, or something about when side effects hit during the ramp-up. If anyone has a theory, I'd love to hear it.

Stomach side effects

The % of people who reported each one at least once. Numbers are 4 / 9 / 12 mg vs placebo.

• Nausea: 13.7% / 20.8% / 28.0% vs 8.0%
• Diarrhea: 27.4% / 33.5% / 33.6% vs 13.2%
• Constipation: 14.0% / 16.2% / 16.8% vs 9.4%

Nausea about doubles from 4 to 12 mg, and roughly a third of people on any dose had diarrhea. Paired with the small extra weight loss at 12, that makes 9 look like the sweet spot.

Dysesthesia

A fancy word for strange skin sensations, like tingling, burning, or skin that feels sensitive to touch.

• 4 mg: 4.5%
• 9 mg: 5.6%
• 12 mg: 7.3%
• placebo: 0.7%

This is the one I keep coming back to. It goes up steadily with dose, and it has shown up in other reta trials too, not just this one. You don't really see it with sema or tirz, so my guess is it's linked to the glucagon part, since that's what reta has that the others don't. I haven't seen a solid explanation yet.

Diabetics vs non-diabetics on 12 mg

• Earlier trial, people without diabetes: ~24% weight loss in 48 weeks
• This trial, people with diabetes: 20.8% in 80 weeks

That's not a knock on reta. People with diabetes lose less weight on every drug in this class, and you see the same gap with sema and tirz.

What's next

Lilly plans to file for FDA approval in early 2027, so reta is still not approved. Most of the other big reta trials have already reported, and this was one of the last major ones before filing.

So, for people who follow this closer than I do: based on this, is 12 mg actually worth it over 9? And has anyone seen research on what's causing the dysesthesia?

Source: Lilly press release + The Lancet, Sept 29. Discussion/research only.

It's a community made for group buying.

The owner of the Grey Labs is Matija, but he has another account called Jay Haze, who is also the one doing the group buy for the group. Jay Haze also owns pureelitepeptides. So this dude is racking in thousands of dollars on membership fee, he racks in 5% of the group buy cost, gets a bigger discount in the group buy, and is now banning people who is calling him out on it. GB3 was such a fail and Jay Haze/Matija is now banning people so they don't get a reship or a refund. Matija is planning on keeping everyone's refund after he kicks them out.

That group used to be good and now they are exiting with everyone's money.

Beware.

These guys are con artist, people in that group are their friends who always defends them as well, but once you speak out against the agenda, you will be banned without warning, and they ban you after you just pay for another month of membership who they get to keep that as well 🫠

Hi all. I'm Jack, I run Claripep, a small UK RUO peptide supplier. Some of you saw my earlier post when I was just getting started, since then I've got the full range tested and I've just put together a few stacks, so I wanted to share and be upfront about it.

Quick background on how I do things, since that's what matters in this space: every batch goes to Janoshik for independent HPLC purity + mass-spec identity, and every single vial links to its own COA by QR and batch number. I label by verified peptide content (m/m), not gross powder weight, so the mg on the vial is the mg that's actually accounted for. All reports are on the site, under each product and in a COA library.

The new stacks (all UK stock, tracked dispatch):

• Recovery — BPC-157 + TB-500
• Growth — CJC-1295 (no DAC) + Ipamorelin
• Longevity — Epithalon + GHK-Cu
• Full Research Kit — the whole range in one go

To mark the launch I've got 25% off everything for the next two weeks with code LAUNCH25.

I'm still a one-person operation and genuinely want the feedback, good or bad, if anyone's ordered or does order, tell me what I can do better. Happy to answer any questions on sourcing, testing, or the reports right here in the thread.

(Research use only, not for human consumption, 18+. UK only for now.)