r/skyrizi

Hey guys! I’m a 24 year old who had Crohn’s for 12 years. Before college I was on stelara which put me into remission, but I was stupid and stopped taking it when I started college. My new GI doctor put me on skyrizi since my calprotectin test came back as >800. Only issue is… it’s been about three weeks since my third loading dose and I just got another calprotectin test which came back as >800. Does this mean skyrizi isn’t working for me or does it just need more time? I know Skyrizi is very similar to stelara so I had high hopes. Hoping to get some opinions to know what to expect during my GI appointment next week.

I’m considering donating plasma four times a month, but I’m currently receiving Skyrizi injections every three months for relatively mild psoriasis.

I’ve never donated plasma before, and my biggest concern is whether regular donations could reduce Skyrizi’s effectiveness.

I’d especially appreciate hearing from anyone with firsthand experience or medical insight. Has anyone looked into this or discussed it with their dermatologist?

Hi all,

I will be travelling soon and need to bring my medication with me. Unfortunately my travel will be for around 30 hours and my travel cooler is only rated for 8-10 hours. I was told not to rely on the airline having space in their refrigerators and that they often don't take medication. I've done a search online and the coolers that I'm finding are all built and shaped for injection pens. I use the Skyrizi on body injector so not sure if it will fit in most of these.

Have any of you experience traveling with the Skyrizi OBI for over 10 hours? And if so what have you used? Thanks all

Just wanted to provide my experience of having the flu while on Skyrizi.

I’ll be honest, I was VERY nervous that because I’m “more prone” to severe upper respiratory stuff I was gonna get hit hard. Thankfully, I was actually good to go and have had worse head colds/flu’s while not on skyrizi. It was gone within 4-5 days, influenza A. So if you’re scared or worried, I’m not saying don’t be cautious but recognize you’re not automatically gonna be crushed just because your chance is elevated.

Hello everyone. Reddit is a place that, although I have just now joined, is a place where I have actually received a lot of solid, no bullshit insight.

I will soon be starting on Skrizi for treatment of long term Crohn's disease. 44 y.o. white man with no other underlying medical issues apart from drinking beer every day (I know, stop that right? I am working on that). I'm 5' 10.5" about 205 pounds most days and work a manual labor job as well exercise semi-regularly. I was a smoker from 1995 to 2025 but I quit tobacco, nicotine, and hard drugs years ago. just alcohol and marijuana

I've had a massive battery of tests from MRIs, cat scans, endoscopy, colonoscopy, camera pill, small bowel series, DOZENS of blood tests, stool samples, etc. I'm sure some of you folks know. Everything apart from my calprotectin (sp?), at 1220 mcg/g, is in range to indicate I do accurately feel like crap though. So apart from the Crohn's I'm reasonably healthy.

Apart from skeletal stuff, hearing issues, and allergies (which might matter). My results as of a few weeks ago:

Trees: maple, mountain cedar, ash, elm, hickory, and willow

Grass: Timothy, Bermuda, johnson, and Kentucky blue plus June mugwort.

Weeds: ragweed, pigweed, English plantain, sheep sorrel, cocklebur, and nettle

Molds: alternaria, cladosporium, mucor, pull aria, curvalaria, aspergillus, penicillum, fusarium, and helminthosporium.

Plus dust mites.

So What do I expect other than hopefully substantially less difficult bowel movements?

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