u/Accurate_Aside_6495

Long ago I stopped wearing skirts and dresses because I didn’t like how they looked on me or felt. We are having a heat wave, out of desperation I went through my closet and found some dresses from many years back. I have lost over 45 lbs since I started on tirz last summer. I put one on and it fits and looks fine. I’ve been wearing it all day. After a few hours I realized I HAVE NO CHUB RUB. Oh my God. 😍

How quickly j street became Hamas 😂

I am approaching 52 weeks on this medication. I started on Zepbound but my insurance dropped coverage after a few months so I switched to compound. I am 59, female, 5'5". Started at 227 lbs, currently I am at 180. A couple of things are coming up for me lately that I'd love some input on. These largely have to do with thinking about how I want to "use up" the rest of my runway. I just titrated up to 10 mg a week ago, from 9 mg.

1. Since I got to 15% total body weight loss (so about 192 lbs or so) my weight loss has really slowed down. For a long time I was losing 1-2 lbs a week. Since I got to 15% it's been more like 0-1 lbs a week and sometimes I will gain. I have read stuff about how as you get closer to goal weight the rate of weight loss really slows down so I am not that worried about it. But I have also read speculation that the medication loses its power to help you lose weight after you have been on it for about a year to a year and a half. I can't tell from what I have read (and maybe that is because no one knows) whether this is because your body fights harder to keep weight on at that point since you have already lost a lot, your body acclimates so much to the medication itself, and/or there is just some time window after which the medication doesn't do that much for you anymore in terms of losing. Does anyone know anything about this question? It would help to inform how I want to approach the rest of the weight loss part of my journey (as opposed to the maintenance part). Like, if I'm not going to lose much more after another few months, then I would want to bump up my doses more aggressively now.

2. My second question is, have there been any studies or discussion about whether going up by 1 or 1.5 mgs at a time is "better" or "worse" for you in terms of how quickly your body acclimates to the new dose, than going up by 2.5 mg at a time, and what the new dose does for you. I understand going up in smaller increments from an attempt to avoid side effects and also if you don't want to get to 15 mg "too" fast (I know different people feel differently about this). After initially going from 2.5 mg for two months right to 5 mg for almost four months, I have gone up by 1-1.5 mg each time, which has largely meant I have had very few side effects and I seem to get a return of some appetite reduction, some satiety, and so on. I can stay on the new dose for usually about 2-2.5 months before I start feeling like it's time to move up again due to starting to feel ravenous and not satiated again. I don't really get much food noise and never have, my problem before tirzepatide always was feeling like I cannot get full or stay full.

By way of background - I exercise (including some strength training) or at least take a significant walk every day, I track what I am eating and try to do TDEE minus 500 calories/day, and I am diligent with protein, fiber, and water. I am not sure where I want to be for goal weight, I'm thinking maybe 160 or so, as the recommended weights for women after menopause tend to be a bit higher and I want to be in a range that is sustainable for me long term. I don't feel like I am in a rush to get there, but if I am reaching a point where I'm going to be running out of time from the point of view that some window on this medication will close for me in a few more months based on some absolute duration of use or by just going up in small amounts, I want to get ahead of that and change my game plan.

Thanks for any thoughts or advice.

I love Bevel but find the nutrition part of it cumbersome and lacking. I use Cronometer and have for quite some time now.

I am wondering if it is possible to take my daily record of nutrition from Cronometer and feed it to Bevel AI as a way to “track” my food in Bevel without entering it directly into Bevel or having Bevel just guess off of Apple Health?

An excellent article by a Palestinian - from a clinical and ethical perspective this recruitment of psychology in Israel to reframe the fallout soldiers feel from participating in war crimes and genocide is really insidious, maddening, and disturbing. When a society launders and DARVOs its actions and constantly reframes the aggressors and the victims, in this case using the imprimatur of clinical terms and treatment, it only entrenches that society's warped understanding of its own choices and narrative further.

Hi I am wondering if those of you who were already on HRT for menopause symptoms notice any increase in those symptoms once you started losing weight on a GLP-1. I am asking because it is known that as we age, our bodies use fat to provide us with the decreased amount of estrogen we have. As I started to lose significant weight on Zep, despite all the great benefits to my health, I began getting UTIs pretty frequently, which is unusual for me. I am currently on .075 mg estradiol patch, 100 mg progesterone, and I also use topical estradiol vaginally. I was using the vaginal cream twice a week but after some Googling I asked my gynecologist if I could use it every other day instead, which she said was fine and it seems to be helping. I also started taking a cranberry and D-mannose supplement which some people on the r/menopause subreddit recommended and that seems helpful too.

I am waiting to see a urologist for this, so hopefully will have some more answers soon, but I have wondered if there is something going on in terms of my possibly needing to increase the estrogen dosage that is part of my HRT, to help to compensate for having less circulating in my body due to fat loss. I have asked my PCP about this and also my gynecologist and it seems like they are not very up on how GLP-1s and/or significant fat loss can affect HRT, which is frustrating but not all that surprising. I appreciate any input and experience anyone can share if applicable.