r/LadiesHRTwithGLP1

Hi ladies! Just started microdosing Tirz after about 5’ish months of P 100mg and E patches 2x/week (using them only when the PMS rage starts lol). I’m on week 2 of 1.5mg Tirz. Wondering if any of you experienced a return of perimenopause symptoms since starting? I noticed it slightly return after 1st shot but now more noticeable since my 2nd shot (Sunday). Sleeps been off and the achey’ness especially frozen shoulder has returned.

After reading a few threads I decided to up my P dose tonight to see if that works. If it does will discuss new Rx for P with my MD.

TIA!

TIA!

What is your dose at what intervals? 4 days? 5 days?

50 on HRT. 100mcg of levo. On tirz for 9 months now. Started at 2.5. Went up to 5.0 for 8 weeks but came back down due to weight loss. I wanted the autoimmune control not the weight loss. Down 45 lbs in 6 months, so i lowered my dose. I’m on 2.5 tirz every 7 days for the last 3 months. My weight has maintained. Here’s the issue, I’ve noticed an increase in my joint stiffness/pain. Bloodwork is spot on. No changes there.
This medication has been a lifesaver. Never coming off of it. I just want to make sure I am using it correctly to achieve the best results. Endo is helpful but he doesn’t actually know what it is like to live with autoimmune. Y’all do! It is a moving target.
My question is, if you experienced a plateau in the effectiveness of tirz on your Hashimoto’s and if so, what did you do? Did you split your dose? Up your dose? Or both? Did you find a sweet spot where you were able to maintain weight and inflammation?

I've been on Zepbound for 1 year, at the 15mg dose since January. I lost 50 lbs in 6 months but had not lost any since October. I tried lots of things to help it along, but it just didn't seem to work effectively for me anymore. Until recently. I again have no interest in food, get full quickly, and have lost 4lbs in 2 weeks.

Then I started feeling sick while and after eating chicken. I have aversions to many foods I've eaten and enjoyed forever. I even threw up after a dinner of 1 chicken tender in shake-n-bake.

I was thinking - oh, the zepbound finally kicked back in. But after some research, I see this is common in peri and menopause and from HRT. I recently went up a dose of my patch, and in retrospect, it correlates.

Is there anyone with experiences like this?

36 almost 37f currently struggling with vasomotor and peri symptoms at 9 months postpartum. I’ve been struggling with low progesterone for years. How do I get a doctor to prescribe HRT? Doctors keep throwing birth control at me and I have ZERO interest in synthetic hormones.

I’m 46, 5’6”, around 160 lbs, and honestly feeling really lost with perimenopause, HRT, weight gain, sleep, and now considering GLP-1s. I’m hoping to hear from women who’ve gone through something similar.

I’ve been on HRT for about 2 years:
\- Estradiol patch 0.1 twice weekly
\- Progesterone 100 mg nightly

The HRT HAS helped some things, especially the rage/mood swings before my period, brain fog, and that “completely losing it” feeling the week before my cycle. But lately I still feel emotionally sensitive, sad, exhausted, and honestly just not like myself anymore.

Over the last 2 years I’ve gained about 15 lbs, mostly in my belly and breasts. My breasts constantly feel swollen/full/heavy, I feel puffy and inflamed all the time, my hair is thinning, and nothing fits the same anymore. It’s affecting my confidence because I don’t even feel like getting dressed or going anywhere half the time.

I work out 4-5x a week (mostly strength training), try to walk/get steps in, and I’m mindful about protein and food overall. I also try to take fiber because I’ve always had digestion/bathroom issues. But despite all of that, I still feel exhausted, hungry all the time, and like my body just keeps fighting me.

Sleep is also terrible. I wake up constantly and probably average around 5 broken hours a night.

I also have adenomyosis/heavy clotting, so I’m wondering if estrogen is making some of that worse too.

Last year I tried compounded semaglutide at a VERY small dose for about a month (even lower than the starter dose) and I was still so nauseous the entire time. It honestly felt like morning sickness and made it harder to even work out because I constantly felt sick. I’m wondering if tirzepatide is any better for people who were really sensitive to semaglutide nausea?

I guess my questions are:
\- Has anyone gained weight or felt constantly puffy/full on HRT?
\- Did lowering your estrogen dose help?
\- Did stopping HRT help or make things worse?
\- Has progesterone made anyone feel constantly hungry?
\- Did anyone eventually tolerate GLP-1s after bad nausea in the beginning?
\- Has tirzepatide worked better for anyone than semaglutide?

There’s SO much information online right now and every ad is another powder, gummy, hormone supplement, fiber drink, peptide, etc. I honestly don’t know what’s normal anymore or what direction to go in.

Would really appreciate hearing from women who’ve actually experienced this.

Hi ladies -

are any of you using the glapp app to track your glp1 medication? Highly recommend.

I love the graph showing the estimate of how much is in your system based on timing and medication metabolism, and would love to have something like that for estradiol patches so that I could better understand and fine tune timing, placement, etc for minimizing symptoms. Does such an app exist? please share!

TIA.

Here is my Dexa from yesterday compared to last June at my initial goal, as well as Jan 2025 when I had already lost 40lbs! Just look at my elbow placement....I wish I had done a DEXA at the start.

I'm 5'4", SW 205, CW 125. Body fat is 28% currently. My current goal to be about 130lbs and 25% body fat. This goal is based on nothing...just sounds nice, so if anyone has advise let me know.

My original goal was 135, which I hit last June. I kept losing about 2 pounds per month for the first few months of maintenance, despite increasing cals and lowering dose. Kept increasing cals and lowered dose again to 7.5mg in November. Now that loss has slowed to less than 0.2 pound per month if I keep my cals around 1850-1900 per day, or even a little more.

I'm keeping a close eye on the Foundayo pill roll out and may switch to that in late summer if my pcp agrees.

I get quarterly DEXA scans and lean mass is holding steady, while fat is sloowwwlllyyy dropping. I strength train 3-4x per week for about 40 minutes and walk 3-5 miles per day. I turn 59 next month, and started menopausal hormone therapy in Jan, so I'm hoping that the MHT will help the muscles grow a bit faster. My OB has recommended adding testosterone gel to my MHT, and I'm getting the blood work next week to see if it's safe for me. While it is for libido, it may help the muscles as well. My libido has been gone for so long that I'm honestly more excited about muscle gains than sexy time, lol.

After almost a year of maintenance and body recomp, I have more definition in my arms, which have always been skinny, and my bra strap area is leaner, much less pooch over the strap. Shoulders are looking nice, just in time for summer. My boobs are mostly gone (a moment of silence for our fallen sisters, please), but the booty is still there, both with muscle and fat. Inner thighs and lower belly still holding onto the typical female softness, which is fine with me. Quads and hams have a modest amount of definition. All in all, I am tickled pink.

https://preview.redd.it/ll2rynsat40h1.jpg?width=826&format=pjpg&auto=webp&s=46981ecdf4e95898062a94296b14e6a1a81c3482

56F menopausal, estradiol patch .075, progesterone 200mg, Tirz 2.5 maintenance, Testosterone gel fda .5ml,
SW 156 CW 125
Totally a share here... I've been able to determine that in order for me to properly absorb the needed 200mg of progesterone, I have to take 2 100mg pills instead of 1 200mg pill. This way I am not spotting or bloated or experiencing that slight bleeding feeling. My gyno NP accepts my experience and wrote my script for the 100's. It was great to be listened to! My guess is that the pharmocodynamics between the 200mg pill vs 100mg alters with Zepbound on board??

F:37 SW:184 CW:176

Currently been on tirzepatide started titrated up and am at 4mg right now. I had to slowly titrate up because I barely had an appetite even on a low doze, it was a struggle to get myself at 1000+ calories a day. I’ve gotten better about finding foods I can eat and that have enough nutrients. I get 90-120 grams per day and shoot for 25-35 grams of fiber a day (this one is the hardest for me with the lower appetite) and drink enough water and throw some electrolytes in there when I need them. I climb/lift/hike/walk 3-5 days a week and I count my calories to just see what I eat each day. I’m sure I’m counting them accurately, I use a food scale and mostly eat at home. I know I’m not overestimating how much I’m eating. I also eat pretty well. Mostly Mediterranean diet with lots of veggies and fruits (am Sicilian)

I’ve been on tirzepatide since January 2026 and have only lost 5-8lbs (it goes up and back down but at my lowest right now it’s -8 lbs) and have just stalled there for 3 months, even after going up in a dose. If I go up anymore I doubt I’ll be able to eat enough, but I will as soon as I can handle it. Thing is, I also have endometriosis and have suspected I have some hormone imbalances for like 10 years now. (Took forever and an 8cm endometria to find out I had endo)

I JUST started bio identical progesterone. Birth Control (nuva ring worked best) kinda helped with endo pain cause I could skip periods, but made all my other hormonal symptoms a little worse.

I’ve done hormone testing at different phases of my cycle several times and the one common thread was that while my estrogen and progesterone (and other hormones) were in normal range, I had far more estrogen compared to progesterone.

Started cyclical bioidentical progesterone a few days ago. And have been taking a liver support supplement that has milk thistle and artichoke in it, NAC. And I just added in DIM yesterday as well as activated charcoal that I take spaced out from other vitamins/meds and meals.

The progesterone so far has no side effects and I’ve been getting the best sleep of my life. So I’ve had more energy and less brain fog. Also immediately lost the 3 lbs of bloating I’ve been carrying around since my last period.

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I know it’s early, but for anyone who needed both hrt and glp-1, when did you see results? Need some hope. Seems like I may be turning a corner, but it’s been a LONG road.

I’ve been carrying around this weight and these symptoms that make me not feel like me ever since I went on the mirena 10 years ago and gained 60 lbs in 3 months. (Side note thyroid has been fine every single time I’ve checked it and have no food allergies or sensitivities). TIA for comments, support, or even just making through this long rant. ❤️