r/LadiesHRTwithGLP1

I am newly diagnosed as adhd inattentive (along with anxiety). I tried strattera (too many side effects) and currently on 150mg XL wellbutrin and 3mg ER guanfacine with no obvious benefits. I have an appt tomorrow to discuss options but wanted feedback from anyone who may be in a similar situation. I have a gastric sleeve, am on a glp1, on HRT (0.075 E patch/200mg capsule P). Given the delayed gastric emptying and stomach modification-trying to figure out what may be some suggestions I can provide tomorrow (not all psychiatrists are familiar with bariatric surgery impact and glp1/HRT impact). Throwing this out there in case anyone is in a similar situation and has any insights.

If so, do you notice any improvement in brain fog? Or anything else? Heard about it on a podcast and thinking of trying it.

What the entire F*ck??? I’ve been menopause for over 3 years. Been on HRT for about 3-4 months. My period came back in today!! Whyyyyyyyyyy 😩😩😩

How can I make it stop!

Any telehealth recommendations besides Defy that does injectable E??

I’m a complete desert! I started at 2mg per week and my legs were itching horribly so I lowered to .5mg twice a week. My weight stalled and now I’m back up to 2mg per week. But dryness is horrible, you ladies know what I’m talking about. I drink 80oz of water per day, + 16oz with electrolytes and 1 light cup of coffee right before going to the gym. My skin needs hydration every day morning and afternoon. Do you think it’s going away in a few weeks or do you have any suggestions?

In short: Tirzepatide was working great for me in maintaining weight but with HRT, it is working less well, and I am having trouble isolating what the cause could be.

Background: I am 43. I still have regular periods, but have a few symptoms of peri.

I started on 1 mg of Tirzepatide on January 1 2026 just to maintain my weight where it was, and allow me to eat like a normal person. Before starting Tirz, I calorie counted (1200 or fewer calories a day) and was on a Paleo diet to lose the 10 pounds my body keeps wanting to gain despite strength training 3 or 4x a week and daily 8-10k steps. I regained and lost this weight three times over the last four years and finally just needed my life to be easier.

Tirzepatide was amazing for me. I lost a lot of inflammation and was easily able to maintain my weight.

I started taking 200 mg Prometrium cyclically (during luteal phase) in March. I started a 0.025 patch of Estradiol two weeks later.

A month later, I started noticing weight gain and some bloating/inflammation came back cyclically as well (i.e., I feel least bloated right after my period, but in the two weeks leading up to my period, my body feels bloated, especially in the stomach area).

It has gone up and down since then, but I definitely feel like the HRT is interacting SOME how with the Tirzepatide to where it's less effective in controlling my appetite and inflammation. I have increased my dose of Tirz - I went from 1 mg per week to now taking 1.75 mg per week. I realize this is still below the standard starting dose, but it was highly effective for me before even at 1 mg. And during the weeks when I was feeling my hormonal flux a lot, I even went up to 3 mg and felt nothing - no appetite suppression - only to find 1.5 or 1.75 effective again once my hormones balanced out.

I should say, energetically and otherwise I feel amazing on HRT. But I have wondered if I am taking too many hormones while my body is still producing enough of its own hormones, since I do still ovulate and have regular periods. I felt like maybe I have too much estrogen, especially since last month, my pharmacy increased my patch dose to 0.0375 because they're having supply issues with the 0.025 dose.

Anyway, curious what others' experiences have been with this. Do hormones fight Tirzepatide? Which hormone could be more responsible for it? I am only 2 lbs up from my goal weight, and only 4-5 lbs up from my lowest on Tirz, so it's not a huge deal, I just hate feeling bloated, and that was one of the best things about Tirz for me was that it took away all inflammation.

I’ve had very low energy for over a year. I was put on estrogen and progesterone that made my other peri symptoms much better. Lately my low energy got worse and blamed reta. Then I realized my brainfog was getting worse too. I insisted on having testosterone and ferritin tested and both came back borderline low.

I am mad at my docs for never testing and mad at myself for not advocating more for myself.

I won’t get an appointment for a few weeks so I wanted to see if somebody here had success fixing ferritin and testosterone. Did it have effects on energy and brain fog? (I had IBS before reta, so my gut absorption isn’t great. I eat plenty of meat and poultry and have 8mg ferritin chelate a day for over 6 months now. )

I started my HRT a 5 weeks ago and my tirzepatide almost 3 weeks ago. I lost 4 pounds with the HRT alone and another 8 in the first 2 weeks on Zep alone. This third week, though, the scale has not moved at all. Not one pound. Is that normal?

My in body scan is telling me I still need to lose 17lbs of body fat. And it lists my PBF as 31%. I just don’t get it. I don’t feel like I have 17lbs to lose and am worried that is an unhealthy goal. I’m lifting twice a week. I have upped my muscle and want to keep going there. And, in the last few years, I have really tried not to focus on the scale. Strong not skinny! But this is messing with my head. Has anyone else experienced this?

Seeing if anyone has any experience or thoughts. I was steadily losing 2.5-3 pounds a week on 2.5mg (I’m a super responder… not trying to flex here in any way as I know this is super unusual)… week 5 bumped up to 5mg and lost 3 pounds with minimal side effects. Took my second dose of 5mg and had horrible side effects… I was nauseous with severe diarrhea for 6 days…. I was so weak and tired and couldn’t get my electrolytes balanced and eventually needed IV fluids to partially recover…. I ended up losing 5.5 pounds due to dehydration.

The doc I saw suggested I go back to 2.5mg as she felt I was losing too fast (at 3lbs a week) and I didn’t argue (side note… I bought through trinity meds as they have pay over time option… I stupidly didn’t research their customer service and they are abysmal …. I have reached out many many times and have gotten no response). I waited one additional day to let it clear a bit and then took 2.5mg. I’ve gained back 3.5 pounds of what I lost that week which isn’t unexpected since I’m actually hydrated now, however It’s been a few days and I don’t feel like it is working the same…. I’m hungrier, there’s more food noise

My question is this…. Is 2.5 maybe not enough? Do I just need to maybe build up the level a bit more? I won’t go back up to 5…. But would maybe do 3mg. Anyone else have an experience like this?

Have any of you switched to once a week after being on twice weekly patches? Due to shortages, the only way I was able to get my estrogen patches this month was to switch to a once weekly patch. My patch cycle was Tuesday-Friday.

The first part of last week I felt great. Better than I had in a long time, actually. Thursday evening is Zepbound injection and Friday I didn't feel as bad as I usually do. (I have bad exhaustion type side effects that start gradually and then taper off gradually, lasts about 2-3 days.) Saturday was BAD. Exhausted, and emotionally just bleh. Sunday I was an emotional mess. It felt like it does when I forget to take my antidepressants for a couple of days. Today is about the same, but usually I'm back to baseline by now. I can't focus on anything and I'm just irritated at life. Seriously considering taking a half day, even though I WFH and could probably get away with doing very little.

I messaged my doctor already to see if it was possible that my body didn't like the once a week deal, but I'm wondering if anyone else went through this if they switched?

UPDATE: I did end up logging off work. I just couldn't handle it.

My doctor agreed that once a week was the issue and sent over a new Rx for twice a week. She also upped the dose since the manufacturer my online pharmacy uses doesn't work as well as the Mylan patches I started with. Now I just have to hope they get here soon. I don't want to go through another weekend like the last one.

Does anyone else estrogen patch get dirty and gross around the edges? Any hacks it’s just gross by end of week.

Hi all. I just got a prescription for Ozempic, and I'm nervous about starting it. I spent what seems like a lifetime committed to health and fitness, on and off. At my fittest (3 years ago), I had a six-pack and was in fantastic shape. But maintaining those healthy habits can be extremely difficult as life continues to throw curveballs, and as such, my weight and fitness levels have fluctuated wildly over the years. I am F/46 and got out of a 26-year psychologically abusive relationship about 4.5 years ago. I went into full-on menopause two years ago, and I have suffered with Ulcerative Colitis for probably 15 years (finally managed now). My 18-year-old son suffers from Major Depressive Disorder, and until about 6 months ago, I had been on suicide watch for several years. Thankfully, he is in a partial remission now, and I want to get my life back. The difficult life path aside, menopause has completely robbed me of the energy I used to have to power through my workouts. I started HRT two months ago, and it's helped, but it's very slow going. My weight has been steadily creeping up over the past 18 months as my workouts have been inconsistent and my meal planning and prep have been pretty much non-existent due to fatigue. Even with a decent diet and some exercise, the scale just keeps climbing. I'm completely exhausted after work every day. I don't know why I'm nervous about starting Ozempic. I honestly think it will give me the boost/motivation I need to get those healthy habits going again. I'm definitely afraid of potential side effects. I'm a single mom with a very demanding job, and I feel like everything is on me. I'm scared. Sole provider, and all that. Any words of encouragement would be appreciated.

I'm (58F) down about 27 lbs since January with about 10-12 more lbs to go to a goal weight of 145 at 5'8". I've been on HRT since 2024 (200 mg progesterone, .05mg estradiol patch, vaginal estrogen 2x/week, and T gel 3x/week.) I started compounded tirzepatide in mid-April. I felt great initially but about 3-4 weeks ago I noticed my energy has been slowly draining. I am in a full body fitness class 2-3 days/week for an hour w heavy weights and functional movement. I was getting 10k steps most days until the humidity outside got too uncomfortable so I had to back off. I joined a gym so I could do the treadmill instead but 1. treadmills bore me to death and 2. I'm tired. So honestly, my step count is down to 6k or so with occasional 10k+ days in the last month

In addition to daily vitamins which include a rotation of D3+K2; B-complex w hydroxocobalamin; liposomal C; magnesium complex; Omega-3 (and maybe a couple I'm not thinking of) I also take 5mg creatine and fortibone/verisol collagen. I'm tracking food intake and my protein hits around 90 grams which I believe is sufficient for my age and activity. With the exception of my collagen supplement, I get my protein from food sources with possibly 2 supplemental shakes per week. The rest is whole food protein. Fiber and carbs are tracked too but vary daily so I can't state a number. Digestion is extremely regular and better than ever. Water intake is at least 120 oz or more per day, I carry my cup everywhere. My sleep has continued to be very good, usually 7-9 hours/night.

I also have fibromyalgia but most of the symptoms faded away once I started the tirz. This current fatigue is taking me by surprise and it feels like the old chronic fatigue/ME feeling of just being zapped of energy. I'm also more irritable because I'm tired and I have brain fog again. No hot flashes though.It just occurred to me that since weight loss can cause loss of stored estrogen in fat, I might need a dose adjustment. I did look through old posts on this topic but I wasn't able to see if there was a weight loss threshold for impact to estrogen. Have I lost enough to make it reasonable that my fatigue is low estrogen? Does anyone have experience with specific weight loss amount and symptoms?

PS - tirz dose started at 1.5 mg and I am currently taking 3.5 mg weekly.

Ive been on HRT since October. .025 estrogen patch and daily 100 progesterone. In the beginning my cycles were irregular. I am in perimenopause, and 50 years old now. I started bc hot flashes and sleep issues. I started low dose .25 wegovy in April. I am down 15 lbs. Still on starting dose. In July I had two periods, and I started again this Saturday. UNCLE. Anyone else? I do have a call into my OB.

Thanks

I started Tirz exactly 2 years ago. I went from 200lbs to 170. I was wearing size 14-16 jeans, then I bought size 10-12 jeans after weight loss.

I had to stop medication due to cost and gained all the weight back. I restarted on April 2026 and got back to 170lbs. HOWEVER, I can't fit into size 10-12 jeans I bought and was wearing last year. And although I'm 30lbs lighter, my belly seem to have zero change. Can somebody explain what's going on, please and thanks!

PS I've been on minimal amount of HRT for peri and I'm 50.

I’m just wondering if anyone else has had this particular issue. I have been on tirzepatide since October and only had minor constipation issues. I started HRT 7 weeks ago (estradiol patch & 200 mg progesterone) and it seems that my bowels have shifted the total opposite direction. I LOVE how I feel otherwise on the HRT but it’s gotten so bad that I’m dizzy and lightheaded a lot of the time because I have diarrhea pretty much every morning. Not really stomach cramping just very loose bowels all the time. Often after I eat too. I don’t know if it’s coincidental timing or if one is affecting the other but I’m hoping for some input from others! (Btw 66 lbs down as of today!)

I've been dealing with brutal hot flashes, mood swings, and zero energy for months now, and everyone keeps telling me to look into bioidentical hormone replacement therapy. But I have no idea if it's actually safe or effective for someone like me, or how it's even different from regular HRT. I just want to feel like myself again without making things worse. Who do I talk to about this?

I’m eating and hydrating flawlessly, I get headaches and wired on injection day and days after. Did anyone else take a while to adjust?