u/Actual-Constant-4288

I was wondering if anyone with experience with this medication could share their thoughts on whether it’s worth giving moclobemide a try.

I’m dealing with severe depression and have gone through a lot of the usual options, but I’ve had to stop most of them because of side effects.

SSRIs/SNRIs caused severe emotional blunting. Bupropion was too stimulating and didn’t really help my depression. Mirtazapine caused significant water retention. Trazodone felt very similar to an SSRI in terms of side effects. I also tried atypical antipsychotics but had profound akathisia.

Moclobemide looks interesting to me because it seems to have a different side effect profile compared to many of the medications I’ve already tried. I’d really like to hear from people who have taken it, especially what side effects you experienced and whether it actually helped with depression or anxiety.

I’m also curious about the diet restrictions. From what I’ve read, it sounds like at typical doses you would generally need to intentionally eat large amounts of high-tyramine foods before running into problems. Is that accurate, or did you find you actually had to be pretty careful with your diet?

I’d appreciate hearing anyone’s experiences, good or bad.