u/AdPuzzleheaded1273

I’ve had two 4 hour gastric emptying studies and both times the technicians have commented that there was a lot of activity in my stomach during the first hour but the food didn’t seem to be moving along.

During that first hour, I get some gas coming up and feel an increasing urge to vomit. I eventually end up vomiting multiple times.
When I return to the waiting room, what comes up is some stomach contents but mainly clear stomach (fluid/juices).

When I return for the next scan after being out of the room for an hour, the technicians have commented that the food has finally started moving through.

Both studies showed a 15% retention at 4 hours.

So I’m wondering, if there’s lots of activity in the stomach during that first hour, suggesting that the stomach is contracting and trying to push the contents through, isn’t that somewhat different from what you’d expect with gastroparesis?
I thought gastroparesis involved the stomach emptying slowly because of impaired or weakened contractions.

I was also prescribed domperidone but it actually made the vomiting worse, so I had to stop taking it.

It seemed to make my stomach contract harder. Normally I’ll vomit multiple times after a meal but with domperidone I would start vomiting about 20 minutes after taking it and even the water I’d taken with the tablet would come straight back up.

Could this pattern suggest something other than straightforward gastroparesis, despite the 15% retention at 4 hours? It’s more like the stomach is pushing but it’s not passing the pyloric to me

I’m wondering if anyone has experience with this or has any insight.

I have a 1 cm prepyloric nodule that was found during an endoscopy. My main symptoms are severe vomiting after eating or drinking. On bad days, I can vomit more than 20 times, even from liquids.
I also have constant epigastric pain about an inch below my sternum.

So far, almost every test has come back normal:
Colonoscopy: normal
Enteroscopy: normal
Capsule endoscopy: normal

The only consistent finding has been the prepyloric nodule.

I also had a gastric emptying study, which showed a slight delay at the 4-hour mark. The technicians performing the test commented that there was a lot of activity in my stomach during the first two hours, but the food didn’t seem to be moving through as expected.

Has anyone had a prepyloric nodule cause symptoms like this, or could a nodule in that location contribute to delayed gastric emptying or recurrent vomiting?

I was diagnosed with delayed gastric emptying following a gastric emptying study and was prescribed Domperidone 10mg to take one hour before meals.

About 20–30 minutes after taking the first dose, I began vomiting repeatedly and was unable to keep anything down. Even when I sipped water to ease the burning in my throat, I vomited it back up almost immediately.

Is this a normal side effect when starting Domperidone, and is it likely to settle if I continue taking it?