u/Affectionate-Peak623

I’ve been thinking about synaptic pruning and the idea of “use it or lose it.”

Let’s say someone was very intelligent at around age 12, but then falls into a long depression in adolescence. From that point on (let’s say until around age 20), they don’t go to school regularly, don’t have much social contact, and generally don’t use the cognitive and social abilities that helped shape their intelligence before.

My question is:

Could this long-term lack of stimulation cause irreversible damage through synaptic pruning, meaning the brain actually loses the connections that made the person highly intelligent in the first place?

And more generally:

Is there a biological “wall” or limit where certain cognitive abilities or intelligence levels simply can’t be reached anymore after a certain age (like after 20 or 30)? Or is it more that everything that was possible in childhood and adolescence is still possible later in life, just harder to reach, but the maximal potential stays the same?

I’m trying to understand whether long-term depression in adolescence can actually lower someone’s cognitive potential permanently, or if the brain remains recoverable if conditions improve later.

Also, for anyone knowledgeable about this topic: if in both depression and schizophrenia there can be significant loss of synaptic connections and network integrity in the brain, what exactly is the key difference that makes the changes in schizophrenia much less reversible compared to depression? Is it just the degree of loss, or is the underlying mechanism of network disruption fundamentally different even if the end result (reduced connectivity) can look similar at a structural level?

I’ve been thinking about synaptic pruning and the idea of “use it or lose it.”

Let’s say someone was very intelligent at around age 12, but then falls into a long depression in adolescence. From that point on (let’s say until around age 20), they don’t go to school regularly, don’t have much social contact, and generally don’t use the cognitive and social abilities that helped shape their intelligence before.

My question is:

Could this long-term lack of stimulation cause irreversible damage through synaptic pruning, meaning the brain actually loses the connections that made the person highly intelligent in the first place?

And more generally:

Is there a biological “wall” or limit where certain cognitive abilities or intelligence levels simply can’t be reached anymore after a certain age (like after 20 or 30)? Or is it more that everything that was possible in childhood and adolescence is still possible later in life, just harder to reach, but the maximal potential stays the same?

I’m trying to understand whether long-term depression in adolescence can actually lower someone’s cognitive potential permanently, or if the brain remains recoverable if conditions improve later.

Also, for anyone knowledgeable about this topic: if in both depression and schizophrenia there can be significant loss of synaptic connections and network integrity in the brain, what exactly is the key difference that makes the changes in schizophrenia much less reversible compared to depression? Is it just the degree of loss, or is the underlying mechanism of network disruption fundamentally different even if the end result (reduced connectivity) can look similar at a structural level?

I’ve been thinking about synaptic pruning and the idea of “use it or lose it.”

Let’s say someone was very intelligent at around age 12, but then falls into a long depression in adolescence. From that point on (let’s say until around age 20), they don’t go to school regularly, don’t have much social contact, and generally don’t use the cognitive and social abilities that helped shape their intelligence before.

My question is:

Could this long-term lack of stimulation cause irreversible damage through synaptic pruning, meaning the brain actually loses the connections that made the person highly intelligent in the first place?

And more generally:

Is there a biological “wall” or limit where certain cognitive abilities or intelligence levels simply can’t be reached anymore after a certain age (like after 20 or 30)? Or is it more that everything that was possible in childhood and adolescence is still possible later in life, just harder to reach, but the maximal potential stays the same?

I’m trying to understand whether long-term depression in adolescence can actually lower someone’s cognitive potential permanently, or if the brain remains recoverable if conditions improve later.

Also, for anyone knowledgeable about this topic: if in both depression and schizophrenia there can be significant loss of synaptic connections and network integrity in the brain, what exactly is the key difference that makes the changes in schizophrenia much less reversible compared to depression? Is it just the degree of loss, or is the underlying mechanism of network disruption fundamentally different even if the end result (reduced connectivity) can look similar at a structural level?