u/AffectionateLand8800

Hi everyone,
I've hit my goal weight and am currently maintaining on 2.5mg of Mounjaro. It's still doing a great job keeping my appetite in check, which is awesome.
I'm not trying to lose any more weight, so I definitely don't want to go up in dose for that reason. But it got me thinking about how this drug works. I know it's not just an appetite suppressant and that it does a lot more in the body, like improving insulin sensitivity and other metabolic benefits.
So I'm wondering: am I missing out on those deeper metabolic benefits by staying on such a low dose? Or does 2.5mg still do the job for overall health even if you're just maintaining?
Curious if anyone else has thought about this or talked to their doctor about it.

How long have you been using Mounjaro?

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For those who take mounjaro for weight management, if you’ve reached your goal weight and are now maintaining, what dose of Mounjaro are you currently taking? (you can reply based on your average weekly dose, even if you’re spacing out your injections)

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Clinical studies generally suggest that Mounjaro has similar efficacy regardless of whether it’s injected in the abdomen, thigh, or arm.
But I’m curious about people’s personal experience. Some people seem to feel that one injection site works noticeably better for them than the others.
So, based purely on your own experience, which injection site feels the most effective for you?
💪 Arm
🫃 Abdomen
🦵 Thigh
🤷 No noticeable difference
Please vote based on how effective the medication feels for you (appetite suppression, food noise, duration of effect, etc.).

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This poll is only for people using Mounjaro for overweight or obesity, not for type 2 diabetes.
Assume your doctor recommends staying on the lowest effective maintenance dose indefinitely to prevent weight regain. Would you be okay with taking it for life?

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I’ve been thinking a lot about the long-term use of Mounjaro for weight management, and I’d really like to hear from people who have been on it for a while.
For context, I was obese (94 kg at 1.68 m) and I’ve now reached a healthy weight after about 10 months on Mounjaro. Fortunately, I haven’t experienced any serious side effects so far.
My concern now is what to do next. On one hand, I know obesity is often considered a chronic disease, and I really don’t want to regain the weight. Mounjaro has made maintaining healthy eating habits much easier, so part of me thinks it would make sense to stay on a low maintenance dose.
On the other hand, tirzepatide is still a relatively new medication. While the results so far seem reassuring, I haven’t found much data on people without diabetes taking it for many years purely for weight maintenance. I wonder whether long-term risks (such as gallbladder disease, pancreatitis, or other issues that could maybe appear after years of treatment) are truly well understood.
So I’m curious… if you’ve reached your goal weight, did you stay on Mounjaro or eventually stop it?
If you stopped, were you able to maintain your weight without too much difficulty?
If you stayed on it, what convinced you that the benefits outweighed the potential long-term risks?
Do you think that tolerating the medication well for several months (without significant side effects) makes it less likely that serious problems will develop later, or do you still worry about long-term safety?
I’m mainly interested in hearing how other people have approached this decision and what factors influenced them.
Thanks!

Hi everyone,
I’m trying to understand something about Mounjaro dosing, especially when it comes to weight maintenance after weight loss.
From what I understand, according to the official prescribing information and Eli Lilly’s recommendations, 2.5 mg is considered only an initiation dose. The treatment is usually started at 2.5 mg for 4 weeks and then has to be increased to 5 mg, which seems to be considered the first official maintenance/therapeutic dose. Higher doses are then increased if needed.
What I don’t fully understand is why 2.5 mg is not considered a valid maintenance dose, especially when some people report that it works very well for them.
I understand that clinical trials were mainly designed around the higher maintenance doses, but I’m wondering whether the fact that 2.5 mg is not officially considered a maintenance dose is because it was proven ineffective at that dose, or simply because it was not studied enough as a long-term maintenance strategy.
For context: I took Mounjaro at a higher dose, lost significant weight, and I’m now trying to transition into a maintenance phase. My goal is not to lose more weight, but simply to avoid regaining it while minimizing side effects. I’m currently on 2.5 mg, but I’m unsure whether this is likely to be enough long term.
I would really appreciate hearing from people who use 2.5 mg as a maintenance dose:
How long have you stayed on 2.5 mg? Has it been enough to maintain your weight? Did you eventually need to increase to 5 mg?

Hello everyone,
I’m posting here because I’m trying to understand what happened to my mother, and I’m hoping to hear from people who may have experienced something similar or who have medical knowledge.
My mother passed away several weeks ago at the age of 60, and I have been left with many unanswered questions.
She had been taking psychiatric medication for almost 30 years. As far as we know, her treatment had been stable for many years and she tolerated it well. Among her medications were quetiapine, amisulpride and alprazolam. I don’t have the exact doses available right now, but I can provide them later if needed.
She also had type 2 diabetes and was taking metformin and gliclazide.
She underwent cataract surgery on her first eye. The surgery went well and there were no complications. However, she was prescribed oral ciprofloxacin, 500 mg twice a day for five days, in addition to her eye drops.
About 20 days after that first surgery, she experienced a severe episode of confusion. For almost an entire day, she was completely disoriented. She didn’t seem to understand what was happening around her. At the time, we never considered that it could be related to the antibiotic.
A few weeks later, she underwent cataract surgery on her second eye. Again, the surgery itself was uncomplicated, and once again she was prescribed oral ciprofloxacin at the same dosage: 500 mg twice daily for five days.
On the fifth day of the antibiotic treatment, she suffered a fatal cardiac arrest.
Since then, I’ve learned that ciprofloxacin can, in some cases, cause neurological side effects such as confusion, and that it may also prolong the QT interval. My mother was also taking psychiatric medications that are known to potentially prolong the QT interval.
I’m not trying to claim that ciprofloxacin caused her death. I simply want to understand whether this combination of medications could have increased her risk or whether there are other possibilities that should be considered.
I have a few questions:
Has anyone here experienced severe confusion while taking ciprofloxacin?
Has anyone seen serious cardiac events or sudden death potentially associated with ciprofloxacin, especially when combined with medications that prolong the QT interval?
Do you think it would still be worthwhile to request an independent medical expert review of her medical records, even though no autopsy was performed?
Unfortunately, no autopsy was carried out, and she was buried several weeks ago. I realize that without an autopsy it may never be possible to know the exact cause of death. However, I’m wondering whether an expert review of available medical records could still provide useful answers.
I’m simply trying to understand whether there are legitimate questions that deserve further investigation or whether this may have been an unforeseeable event.
Thank you very much to anyone who takes the time to read this and share their thoughts or experiences. I would really appreciate your advice.

Hi everyone,
I have a question about restarting Mounjaro after a break and would really appreciate your experiences.
I’ve been on Mounjaro since August 2025. I started at 2.5 mg and gradually titrated up monthly until reaching 10 mg. I stayed on 10 mg for about 3 months, then reduced to 5 mg (from mid-February to mid-May 2026).
I stopped on 16 May due to medical reasons and I’ve now had a break of around 5 weeks.
My question is:
After a 5 week break, is it generally okay to restart directly at 5 mg, or is it usually recommended to go back to 2.5 mg and re-titrate?
I tolerated Mounjaro well overall (no major side effects), but I’ve never had such a long interruption before, so I’m unsure how my body will react.
The issue is also practical: I’m currently using a 10 mg pen to deliver 5 mg doses, and I’d prefer not to restart at 2.5 mg unless necessary.
Of course I will also confirm with my doctor, but I’m interested in hearing from people who have had similar breaks and how they restarted.
Thanks in advance!

Hi everyone,

I have a question about a Mounjaro pen that I’m not sure whether I can continue using or discard.

I started using a 10 mg Mounjaro pen on April 15 and was taking 5 mg doses from it. I used it until May 16, then had to interrupt it for medical reasons.

The pen has remained refrigerated the entire time. I am planning to take my next dose on June 12. There are still 3 doses left in the pen.

Given that the pen was first used/opened on April 15 and will have been unused for several weeks, would you still use the remaining doses, or would you discard the pen and start a new one?

Thanks in advance for your advice.