r/MounjaroMaintenance

Hi everyone,

I just started Mounjaro and I am spiraling into a total panic reading all the posts about people gaining all the weight back after stopping the medication. I’ve been googling all day and I really need some positive stories and reassurance.

Here is my background: For most of my life, I was naturally lean/normal weight. However, the last 3 years were extremely stressful for me, I completely let myself go, and I gained a lot of weight. I went from 58 kg (128 lbs) to 79 kg (174 lbs) – my current height is 160 cm (5'3").

My endocrinologist suggested I start this medication, not just for weight loss, but to help fix my hormones, regulate my period, and get my body back on track.

Because I spent most of my life at a normal weight, I already have good, healthy habits built in. I know how to track calories, I know what "hidden calories" are, and I don't suffer from constant food noise. My plan during and after Mounjaro is to stick to a strict routine: lifting weights/strength training, eating high protein (100g+ daily), lots of fiber, and keeping my maintenance calories around 1400–1500 kcal while staying active. I also plan to taper off the dose very slowly under my doctor's supervision instead of quitting cold turkey.

Logically, I know that if I keep my calories in check and build muscle through strength training, it is physically impossible to gain fat back. But the statistics from clinical studies are messing with my head and making me so anxious.

Has anyone here successfully maintained their goal weight after completely stopping Tirzepatide/Mounjaro by relying on strict lifestyle changes, tracking, and weightlifting? I just need to know that the horror stories on Google aren't a 100% guarantee for everyone.

Thank you so much!

I started my Mounjaro journey back in November 2023 and have been incredibly lucky with it overall. I stayed on 2.5mg the entire time and lost the 12kg I wanted to lose within about 6–8 months. That dose was then enough to maintain my weight really well for many months.

The problem was tolerability. My blood pressure would often crash after my injection and I’d feel exhausted for a few days afterwards, sometimes with quite a low mood too. I initially tried spacing my injections further apart, but that wasn’t ideal either, so about 1.5 years into my journey I started experimenting with microdosing.

I’ve tried a few different doses and intervals since then and, for a long time, managed to maintain my weight perfectly while avoiding the side effects, woudl only shift up and down a few 100 grams for a long time, I was sailing!

But something seems to have changed over the last 6 months. It just doesn’t feel as effective as it used to, and I’ve gained around 1–1.5kg that I simply cannot seem to shift. I know that’s not a huge amount, but what worries me is whether this is the beginning of the medication becoming less effective for me.

At the moment I’m taking 1.7mg every 6 days. I moved from every 7 days to every 6 days to increase my overall exposure slightly without increasing the actual dose too much, as I really don’t think I can tolerate a significantly higher dose.

I’m 54 and menopausal, so I’m very aware that hormones, body composition and metabolism can all be part of the picture. At the same time, I was already dealing with hormonal changes when I originally started Mounjaro and it worked incredibly well then.

Has anyone else who has been on a low dose/microdosing long term experienced something similar, where it suddenly seemed to lose some of its effectiveness? Did you manage to get things moving again without dramatically increasing your dose?

I’d really love to hear what worked for others, especially anyone who had side effects that prevented them from simply moving up the usual dosing schedule. I’m trying not to overreact to 1–1.5kg, but I’d like to understand what might be changing before it turns into a bigger regain.

Bit stuck, been on mounjaro 2.5 years lost 4 stone in 2 years but last 6 months nothing. I'm training 3-5 days a week resistance and cardio and averaging 2000 cal a day as an 18st male. Not sure how to get more fat loss. Days I'm not resistance training and cardio I am walking fasted for 30 mins where I burn approx 400 cap and the other days of resistance/cardio my workouts burn between 500 and 750 cal. I'm changing shape but the stubborn fat on stomach and chest isn't really going. Mounjaro only ever gave me that feeling of not wanted to eat mabey 5 times but has lowered my food noise and usually stops. Me snacking. Any advice

I’ve been on Mounjaro 5.0mg since August 2nd. I take my shot Sunday nights. If I eat spicy, vinegary and oily foods the next day, am I more prone for nausea/vomiting than if I was to eat it later in the week?

Do yall still get nausea after being on Mounjaro for a while? What triggers nausea for you?