Oral Glycopyrrolate for Mild-Moderate Palm and Feet Hyperhidrosis — Anyone with Similar Severity Had Good Results?
22M with mainly sweaty palms + feet — anyone with similar severity had good results with oral glycopyrrolate?
My palm sweating severity is kind of random:
- ~15% of the time completely normal/dry
- ~50% moist but tolerable (can still use phone normally)
- ~20% enough to form droplets while using keyboard/mouse
- ~15% very severe, almost like freshly washed hands, especially during exercises involving grip/strength like pull-ups
Feet sweating is more constant when wearing socks + covered shoes, but surprisingly when barefoot at home, I’m mostly dry.
Other things I notice:
- hands are perfectly dry during sleep / after waking up
- hands get cold very easily in aircon
- sweating happens regardless of weather
- exercise is a major trigger
Treatments I’ve tried:
- Aluminum chloride — barely helped and made my hands feel terrible
- Oxybutynin — worked amazingly at first, then effectiveness dropped after about a month. Also caused dryness side effects.
I’m now considering trying oral glycopyrrolate before deciding whether to proceed further with ETS discussions.
For people with similar sweating severity/location:
- Did glycopyrrolate work well for you?
- What dosage worked?
- Did effectiveness stay consistent long-term?
- Were side effects manageable?
- Did it mainly help palms, feet, or both?
Would really appreciate hearing experiences from people with similar severity and location. Thanks!