Probably very trivial, but!
How do you consistently hit skill shots?
About Q I understand the concept of Q out of fog of war, or throwing W first. But what about R? Lvl11/16 for chunking the enemy adcs.
Living on d4 rn and I can feel that in some games it’s like I’m scripting and in some I can’t hit anything 😅
O find myself building Rylais every now and then
The title basically.
Last year my mom got diagnosed with lung cancer, and we found it due to the cancer being spread to her pelvic bones. We did radiotherapy, chemotherapies/immunotherapies and then proceeded with immunotherapy alone. She saw shrinkage of the primary lesions of 60-70% and complete disappearing of her secondary lesions. Her PET-CT was clean a month ago...
Yesterday, she had an epileptic episode out of the blue and we found she has a brain met (or mets). I live 3000km away. I have no idea what to do from here, or how to even begin to process it. Everyone was so optimistic for her case. I read 3-6 months median survival time.
New to bioinformatics analysis of scRNAseq data here. In preparation to seq our own samples, we are also analysing some publicly available datasets about a TME stromal population.
Following multiple clustering trials we can detect a persistent population of cells that was sharing beyond others IEGs like FOS, JUN and the mechanosensitive KLF2, also HSPs, ATF3 etc.
I came across a couple of papers describing the so-called dissociation stress bias, caused by the enzymatic/mechanical dissociation of tissue. There they show that a set of genes are up regulated because of tissue dissociation, a big fraction of which is also up regulated in the dataset we were analysing…
Have you ever encountered this in your datasets? How do you deal with it, or how do you make sure this is cellular stress because of the dissociation?
Recently I picked up my guitar for the first time since 2020. And I have been having seeing improvement in speed by improving how I hold the guitar, and practicing slow-to-fast tempo more patiently, which I was not doing before.
I noticed something and I want to know if it normal.
I am a bit restricted on playing unplugged at the moment, but I noticed that my playing gets faster when my sound is not as loud. Basically, I remove most of the tension on holding my pick and I gain speed. Is this how it should be? Or should I try to make also bigger noise when I pick with little tension? Is this even possible? I am trying to get the basics better that I ignored as a kid :)