u/Chance-Blackberry834

Has anyone else had months of fasiculations (bodywide) with notable atrophy of the hand muscles and have it turn out to be a non dominant discrepancy vs. actual illness?

My left hand definitely exhibits atrophy, as this was noted in my first neurological exam... but my EMG NCS was grossly negative when tested in the arms bilaterally.

This is the symptom I cannot get past and I just need some input from others in the same boat. I should note that my hands both cramp and ache on and off from general light use, which I always attributed to the twitching.

Okay so... the long story goes... as it always seems to.

Jan 1, 2026- wake up after a migraine with the wildest brain fog- feels like I'm drunk and I am stone cold sober, as I was the night before. Chalk it up to post-migraine symptoms. 3 days later- I feel worse. Make an appointment with my PCP.

She does a rainbow of labs, basic assessment, EKG and because I'm persistent puts a referral out to neurology. My generalized labs are as follows

Normal findings include:
✔ No laboratory evidence of active muscle breakdown (normal CK, aldolase, myoglobin, LDH)
✔ No significant inflammation (normal CRP, ESR only minimally elevated)
✔ No evidence of common autoimmune disease (negative ANA)
✔ Normal thyroid function
✔ Normal kidney and liver function
✔ Normal electrolytes that commonly contribute to muscle symptoms
✔ Normal B12 metabolism (supported by normal methylmalonic acid and homocysteine)
✔ Normal copper
✔ Negative testing for myasthenia gravis antibodies
The only notable abnormalities you’ve had are:
Vitamin D deficiency, which improved from 17 to 39.3 after supplementation.
Ferritin around 20–23 ng/mL, suggesting relatively low iron stores despite a normal hemoglobin.

Additionally my clinical exam with the neurologist did yield mild atrophy of my left non dominant hand- to which he thought I had carpal tunnel. Then comes the MRIs, EMG, NCS.

Electromyography (EMG) & Nerve Conduction Studies (NCS)
Bilateral upper extremities
Result: Grossly normal
No evidence of:
Active denervation
Motor neuron disease
Peripheral neuropathy
Carpal tunnel syndrome
Cervical radiculopathy
Significant nerve injury

MRI
Brain MRI (without contrast)
Normal
No evidence of findings that would explain your symptoms such as:
Stroke
Brain tumor
Large structural abnormalities
Obvious signs suggestive of demyelinating disease on the study you described
Cervical spine MRI
Essentially normal
No significant spinal cord compression.
No nerve root compression that would explain widespread symptoms.
Straightening of the normal cervical curve (“military neck”) was noted, which is commonly associated with muscle tension or spasm but is often nonspecific.

Physical therapy evaluation
Your physical therapist identified several findings:
Significant neck and shoulder muscle tightness.
Possible thoracic outlet syndrome (TOS) contributing to your left arm symptoms.
A visual accommodation problem (one eye focusing differently than the other).
Visual exercises (such as the Brock string) reproduced dizziness and even triggered a migraine.
Interestingly:
Your left arm tingling improved with physical therapy.
Your dizziness was less responsive.

Here we are 6 months later with ongoing full body fasciculations (all day, every appendage, no noticeable trigger), I continue to feel on and off like I am floating through life.

I am waiting on an ENT referral and lower body NCS/EMG. While I continue to be baffled that nothing is showing up on routine lab work.

I'm 35F, white, nondrinker, non smoker, non drug user. 2 cups coffee day. No other past medical
History. 5'10" 175 lbs. regular exercise and sleep. I realize anxiety is a critical piece of this puzzle, but it does not explain the abruptness of my onset or the veritable wax and wane of my symptoms.

Should I be asking for something else?

Hi all. 35F started having weird brain fog/floating feeling in Jan 2026 and the full body twitches started a month after. I twitch all over- legs/arms/back/shoulders/abdominal wall/thumbs/butt- you name it. Both sides without warning all day. Nothing seems to make it better or worse. As do many, the tremors and muscle soreness that come with twitching are also present- probably made worse by constant attention to the twitching. Mine is most notable in my thumbs bilaterally and upper ribs.

Now- I've seen both my primary care and a neurologist more than once. I've had countless labs/scans including MRIs/electrolytes/heavy metals/thyroid/iron panels/ultrasounds/EMG/NCT. Nothing has been out of whack except a vitamin D of 17 and a ferritin of 23. I ask this of this group because it's incredibly hard not to spiral when it seems the symptoms persist and because I know that the anxiety component makes it ten fold worse.

How do you deal with this? Has anything helped? Will I ever feel at peace from these symptoms?

I should add I'm an RN and mom of 4 young kids.