u/DVHellsing

The Tainted spell now counts as Fire Skill (benefits from Magefist bonus), does anyone know what other runewords or uniques will now affect it post patch?

The resource management (needs) are fairly manageable that it isn't overbearing until you become negligible about this over time. Ammo weight changes up the hoarder mindset- requiring more strategic planning and enforces new build variety with melee/unarmed. Weapons like MF Hyperbreeder are more invaluable as sidearm, Pack Rat perk has more importance for lowering munitions weight. Healing limbs is much difficult without doctor's bag and there's also limitations with stimpacks healing over time only/no longer heal limbs separately. You need bedroll/owned bed for the full rest.

I'd say the most damning change is companions marked non-essential. No problem for people who don't bother with them, though personally love rolling with ED-E + humanoid follower for the additional meat shield+inventory space. Knowing they don't come back up anymore after battle does hurt. With Rex, he's always first to go in skirmishes against Legion Assassins/Deathclaws- poor boi can't help himself. :( Now keep him at the King's place.

Overall, I'm enjoying the experience so far.