Potentially unusual LDN side-effects (or unrelated)?
Forgive the terse writing, I'm just trying to keep this short.
I have POTS, EDS, & Sjogrens and was prescribed LDN to potentially help sometimes severe coat hanger pain. It might be helping, but I'm not even totally sure as just after starting I became extremely sedentary due to some bizarre things that have happened since then and my pain would often be at it's worse when trying to exercise.
2-3 days after starting at 1.5mg my right ankle randomly started bothering me and became really stiff, liking to crack from flexing it and then by the night it felt like it was going to explode and was in terrible pain, I didn't sleep. Next day it was a bit better but the same process kind of repeated by night and then I also noticed it had swelled up quite a bit all around the ankle, with a little in my 1st metatarsal as well. Went to urgent care, said to treat it as a sprain, gave me a splint and I started using a crutch on that side. It slowly recovered (still with pain and other issues) but I was able to start walking a little again after about 2 weeks. After a few days I was crutchless (around the house).
Then I (a little late) upped my dose from 1.5mg to 3mg as instructed and that same day, by the night it was acting up extra so again and the swelling increased to about 80% of its previous max. I returned to a crutch and have been on it since (~1.5 weeks). The swelling is now much lower again but I feel like I can't walk on it at all and there is still a fair amount. In addition to the occasional pain it also on-and-off has this weird nerve pain issue where it feels like the foot and part of that calf are being tickled but in a way too intense way, kind of like accidentally touching a live AC wire or rubbing "the head" against cloth post "finishing", or one of those stupid prank handshake buzzers, where the feeling is so intense it distorts into something really uncomfortable, especially at night. It's also kind of like if you know what hitting a ball on the short part of a bat is like on your hands, or when you bump a limb that fell asleep against something. You get the idea. At it's worse it almost feels like it starts to bleed into the upper leg too but that could just be a perception thing. There is also some sharp pain in the foot here and there.
In addition, most of the entire time I've been on this I've also on-and-off experienced some weird feelings of muscle weakness, increased spasms, soreness and a more milder version of the sensation above in a few other places, namely the wrists/forearms. The left foot also seems to experience some sharp pains and a touch of the other stuff but it never swelled up and I can still use it, mostly with no issue. Also have had chills occasionally, though that is something I've had on-and-off for a while now, though I think the frequency has increased.
The POTS related blood pooling in that foot has also be consistently worse than the other ever since all this.
The prescriber, although remaining open minded, doesn't think the LDN is related, which I'm willing to believe, but the timing is also incredible.
Just curious if anyone else has ever had anything really weird like this happen right after starting LDN. I'm pretty good at not wearing a tinfoil hat, but it's often quite hard when I seem to have weird sensitivities to various medications, so I'm trying to feel out if there's any real legitimacy to a possible connection.