r/LowDoseNaltrexone

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Hi everyone. I have Slipping Rib Syndrome (SRS) / suspected hypermobility of the lower ribs and I'm wondering if anyone here has tried **low-dose naltrexone (LDN)** for the chronic pain associated with it.

I'm especially interested in whether LDN helped with rib/intercostal pain, nerve-type pain, muscle tension or sensitivity around the affected ribs.

If you've tried it, what dose did you use, how long did it take before you noticed any effect, and did it make a meaningful difference?

I understand LDN wouldn't correct the mechanical problem itself. I'm mainly interested in people's experiences with pain and associated symptoms.

Thanks!

Doing my usual over analysis after my consultation.

I was given the choice of liquid or sublingual. I expressed my concerns that I think I have MCAS and I react a lot to most things and I'm also worried that I maybe don't absorb via my stomach well. So she said ok we'll go with sublingual, despite most people going for liquid.

But I then expressed my concern that sublingual might not absorb so well and I might not get the right or consistent dose. She said that if it's swallowed it becomes neutralised.

I was trying to ask for a medical opinion but she didn't give it, just insisted it was my choice. So I went for sublingual.

But I'm instantly worried and regretting it after reading most people take liquid.

Anyone here take sublingual? Anyone tried both? Are my concerns about absorption from either valid? Is there a difference or should I expect the exact same results?

I’d love to hear some positive feedback before I consider the LDN journey. 53 F, on HRT, taking Mirtazapine for sleep but it doesn’t keep me asleep. I want desperately to get off the benzos to top me up on sleep. I’m out of options and considering LDN but feeling very apprehensive after reading all the conflicting stories.

I have severe anxiety and nerve damage and tride multiple medications now I’m taking cymbalta lyrica and blacofen.

I heard about this drug how it somehow helps nerve pain even though it’s an opposite opioid. Anyway my question was how does it affect drugs and alcohol

I use oxy weed and some alcohol. Weed and ocy I use for pain and relief and anxiety relief. Alcohol I use to drink as medicine but I switched to oxy so only once in a while

any would it stop weed and alcohol I know it stops oxy

Hi everyone, I'm taking LDN for complex trauma/related somatic complains

When starting fresh I can feel positive effect within less than 30 minutes.. I drop back into my body the pain is still there but it's workable, and it's like dropping a 50 kg backpack

After sometime it stops working I try upping the dose, but my understanding is it's a different mechanism than LDN so it kinda defies the purpose. Any ideas?

I have my 1.5mg prescription but I’ve read more bad than good about LDN and now scared to start it. Also, it seems that this med only has a temporary effect, no actual healing? I’m still learning. Please help convince me that I should take LDN or something else.

My issues are long COVID related vascular issues causing vascular headaches, PEM, CFS, POTS, stomach and upper respiratory issues. I’ve most addressed my IBS with klow peptides. Vitamin d helped a lot with my upper respiratory issues. Still trying to address the migraines, POTS, PEM, CFS. I am extremely tired each day without doing anything. Even after getting 7-8 hours of sleep l can wake up and go right back to sleep after dropping my son off at school.

What I’ve started recently: fibrinolytic peptides and beet root supplements because I read it might help. Still trying to figure out a solution to this. I also had a positive ana 1:80 and ssa but not enough to be referred to rheumatologist.

I already have poor sleep from being perimenopause that I’m addressing with magnesium glycinate and ashwaghanda. I’m not willing to sacrifice sleep issues with any meds.

Any suggestions what I should do and if to proceed with LDN or will the fibrinolytic enzymes and beet root supplements work just as well. Thanks

Hi. I'm new to LDN & this subreddit.

Can anyone talk to me in simple language about treating chronic pain - what to expect etc?

I say in simple language because I have Mild Cognitive Impairment, which means I have trouble understanding complexity. Linear thinking is hard. I can't read technical writing, like scientific papers, anymore.

I started at 1.5 mg for 10 days. I moved to 3 mg for 10 days. Tonight, I go to 4.5 mg.

Other than a week of the worst brain fog I've ever had, I don't really feel like anything is different. When did the pain relief start? How do I know if I need more or less or different timing?

I would very much appreciate any advice that speaks to LDN use with respect to MCI.

I have 1.5 mg capsules with sucrose with an expiration of 1/17/2024. They were stored in a dark cabinet (not bathroom). Can I still take these? They look ok and are not sticking together.

Soo I started LDN at .5mg almost 2 weeks ago to hopefully help with my MECFS. Side effects are getting a bit better I think thankfully. However... now a PA at my ENT's office prescribed me prednisone (60mg for 5 days then slowly taper down until I get to 10mg on day 10 and after that I stop) for ear fullness and pressure that I've been dealing with for MONTHS. I've had no success with other treatments so far and the next closest appointment isn't until October. My pharmacist said he didn't see any interactions between the two when he checked, but I still wanted to ask if anyone else had any experience taking both medications together.

I have 2.5mg caps with Loxoral as the filler. Can the contents be dissolved in water the same way as the ones with Microcrystalline Cellulose? I’m looking to experiment with an ultra low dose of 0.01mg, and the 2.5mg caps are all I have access to right now. Can I still do it?

Today my rheumatologist agreed to me trying LDN. She said to give it a good 3 to 6 months. She said she was sending in a prescription for 4.5 mg capsules. I questioned her, mentioning that everything I've heard and read says to titrate up. She says that is old and she has lots of patients she has started at 4.5 and they do fine.

Does this sound crazy or okay??😬😬

Anyone on LDN then added nicotine patch (non-smoker), how did it go? Any advice, tips, anything to watch out for?

Did the degree/intensity of **initial** side effects correlate with how effective that dosage went on to be for you?

Like, did rough initial side effects predict an unsuccessful dosing experience, whereas you got fewer initial side effects with the dose that turned out to be the right one?

Or doesn't it work like that?

Am I making any sense here?

Hello all! I am 27F and 4 months postpartum with my first baby. I’ve struggled with insomnia my whole life life, as well as anxiety/OCD/fatigue/autistic behaviors. My insomnia improved in pregnancy but has recently severely worsened. My baby will be asleep but I’ll lay asleep for hours. Some of it is sleep pressure/sleep anxiety/knowing my baby will wake up and need something, but some of it also feels biological if that makes sense. I also have been breaking out in massive welts on my body. My doc thinks it might be autoimmune and LDN could help my welts as well as my insomnia.

I’ve heard some people say LDN worsened their insomnia, at least temporarily. Others say it wildly improved it. I couldn’t imagine my insomnia worsening, I think I’d die. I’ve already had a mental breakdown and hallucinations due to it. However, if LDN could help me I’m very intrigued.

How did LDN impact your sleep?

Thanks!

I’ve been having daily headaches for like week or two and trying to figure out if it’s from LDN or not. I was on a hair loss medication that can cause then but stoped that and still having them. My neck has also been hurting so thought that.

I’ve just never had tension headaches everyday like yhis. On 0.5mg for 2.5 weeks now. If from LDN csn headaches improve? In two weeks dr sent inscript for 1mg so now I’m nervous since just paid $135 for it

Hi everyone,

I wanted to share my LDN experience and titration so far in case it’s helpful to others, and to hear from people who’ve been in a similar place.

Background:
I have ME/CFS. Started LDN in mid-June 2026.

Titration timeline:

• Mid-June: Started at 1.5 mg in the morning
• July 2: Increased to 2 mg (switched to bedtime)
• July 23–24: Increased to 3 mg total — 1.5 mg morning + 1.5 mg night

I’ve now been on the 3 mg split dose for about 3–3.5 weeks.

Current effects:

• Positive: Feeling a bit more motivated and slightly more energized. Overall I think it’s helped both my energy level and mood.
• Pacing: I still use the Visible app and try hard not to exceed my points. I can still feel when I’ve overdone it. I’m not completely sure if I’ve had true PEM because I’ve been very careful about avoiding excess exertion.
• Side effects:
  • If I take the 1.5 mg nighttime dose too early, I get pretty fidgety and it makes falling asleep harder.
  • Either dose can make me nauseous if I don’t take it with food.

I’m starting to feel like I may be near my optimal dose, or possibly a little over it — though that’s just a guess at this point.

Would love to hear from others who’ve used a morning/night split, especially around the 3 mg range, or who dealt with fidgetiness/sleep issues from the nighttime dose. Any tips on timing the evening dose or managing the nausea would also be appreciated.

Thanks for reading.

Only 20mins long and very easy to understand.

Be aware the video doesnt mention LDN or MECFS at all, it just talks through the function of microglia, which helps us understand what "modulating microglial activity" might mean and why it might benefit us

If anyone's able to chime in with a little more about the pharmacological effects of LDN please do :)

I started on July 31st with 0.25 mg. Every two weeks I increase by 0.25 mg. So now I am on 0.5 mg and I'm doing great. My headache is better, even my sore throat. My fatigue is still there, but I am now able to cook and go on little walks (400-600 meters). My neurologist says the end dose should be at 4-5 mg.

How is your medication and increase going? How does it work for you?

https://drive.google.com/file/d/1Pi18yluG7ZerzarXfOs9xxFh0NBMfM0r/view?usp=drivesdk

https://preview.redd.it/mzejxmcehtjh1.png?width=1474&format=png&auto=webp&s=d2d1bb987bf5303bd293222b3cc8a5ad74e71dfe