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u/Dry_Jello2272

r/IMadeThis r/AndroidClosedTesting r/roastmystartup r/SideProject r/PinoyProgrammer r/pdf r/Anxiety
[100% FREE & Local] My PDF editor that preserves original fonts just got a massive V2 upgrade: In-browser OCR, Pro Sign & standalone tools.
▲ 4 r/AndroidClosedTesting+1 crossposts

[100% FREE & Local] My PDF editor that preserves original fonts just got a massive V2 upgrade: In-browser OCR, Pro Sign & standalone tools.

Hey guys,

A couple months back i shared my local pdf editor here (the one that keeps your original fonts intact when editing). The feadback from you guys was insane, and alot of people reached out asking for way more than just simple text editting.

So I basically spent the last few months rebuilding it into a full PDF suite for V2!

Heres whats new in this version:

  • Upgraded Studio + OCR: added in-browser OCR so you can finaly edit scannned docs. Completely redid the rendering engine for crisp exports and loaded the toolbar with tons of layout options.
  • Pro Sign: real encrypted signatures. Not just slapping a transparent png on top like most sites do, but actual encrypted signature standards right inside your browser.
  • Standalone Tools: built dedicated utilities outside the main editor (Word-to-PDF, compress, redact, protect, etc) so no need to rely on sketchy converter sites anymore.

Also quick update: the Android version will be availible on Google Play later this week!

The main philosophy is still teh same: 100% local, zero files uploaded to any server, no account needed, and no paywalls.

Just pushed the update live today. Since theres a ton of new stuff under the hood, there might still be some small bugs here and there... if anything acts weird on your end, let me know in the comments and ill fix it asap!

Cheers PdfNoLimit

u/Dry_Jello2272 — 19 hours ago
▲ 24 r/pdf+3 crossposts

My free, local PDF editor that keeps original fonts just got V2: Upgraded Editor Studio (OCR, Pro Sign, feature-packed toolbar) + a full suite of standalone PDF tools

Hey everyone,

A few months ago I posted my local PDF editor here (the one that lets you edit text without ruining the original fonts). The feedback from this sub was really encouraging, and a lot of you reached out asking for features that went way beyond basic text editing.

So I worked on V2 to upgrade the Editor Studio and build a full PDF suite around it.

Here is what's new in V2:

 Upgraded Editor Studio: I added in-browser OCR so you can finally edit scanned documents. I also overhauled the rendering engine for much higher export quality, and packed the toolbar with options so you actually have full control over your layout.

 Pro Sign: Real encrypted e-signatures. Most free sites just let you paste a transparent PNG of your signature, but Pro Sign applies actual encrypted signature standards locally in your browser.

 Standalone PDF Tools: Outside the main editor studio, i built a whole menu of standalone utilities (Word-to-PDF, Compress PDF, Redact, Protect, etc) so you don't have to bounce between sketchy converter sites anymore.

And the core rule hasn't changed: still 100% local, runs entirely in your browser, zero server uploads, no sign-ups, and zero paywalls.

I just pushed V2 live today. Since there are a lot of new moving parts, there might still be some bugs .... if something breaks on your end, let me know in the comments so i can fix it!

Cheers.

u/Dry_Jello2272 — 3 days ago
▲ 2 r/Anxiety

SAD Medication Ranking by LSAS Effect Size (Weakest to Strongest) + Why Low Doses Fail

A major reason medications frequently fail in Social Anxiety Disorder (SAD) is that people are maintained on basic starter or depression-level doses. Clinical trial data shows these lower doses routinely fail to separate from placebo in social anxiety protocols.

Social anxiety requires higher dosing thresholds to reduce amygdala hyper-reactivity compared to major depression or generalized anxiety.

Below is the summary ranking of SAD pharmacotherapy based on published psychiatric literature (Mayo-Wilson 2014, Blanco 2002, Curtiss et al.) using Liebowitz Social Anxiety Scale (LSAS) effect sizes (Hedges' g, SMD, ES), ordered strictly from weakest/ineffective to strongest, contrasting ineffective starter doses with validated effective clinical trial doses.

TIER 1: Ineffective or Marginal (Placebo Level for SAD)

  1. Atenolol (Beta-Blocker)

Starter/Low Dose: 25 mg/day

Tested Dose in Trials: 50 – 100 mg/day

LSAS Effect Size: g: 0.10 (not statisically significant)

Mechanism / Outcome: Peripheral β1β1​ blocker. It stops heart rate spikes and tremors, but completely fails for actual cognitive anxiety & social avoidance on the LSAS.

  1. Buspirone

Starter/Low Dose: 10–15 mg/day

Tested Dose in Trials: 30 – 60 mg/day

LSAS Effect Size: SMD: -0.18 (marginal)

Mechanism / Outcome: 5-HT1A5-HT1A​ partial agonism is too weak to alter amygdala reactivity. High dropout rate in trials due to lack of effect.

  1. Citalopram (SSRI)

Starter/Low Dose: 10 mg/day

Tested Dose in Trials: 20 – 40 mg/day

LSAS Effect Size: SMD: -0.22 (not statistically significant)

Mechanism / Outcome: The SSRI outlier. Fails to hit statistical significance vs placebo in global research reviews, mostly due to weak study power in dedicated SAD trials.

  1. Quetiapine (Atypical Antipsychotic)

Starter/Low Dose: 25–50 mg/day

Tested Dose in Trials: ~147 mg/day avg

LSAS Effect Size: SMD: -0.28 (not statistically significant)

Mechanism / Outcome: D2/5-HT2AD2​/5-HT2A​ blockade doesnt fix conditioned fear circuits. Plus sedation & metabolic weight gain make it a poor choice.

TIER 2: First-Line Antidepressants (Moderate Efficacy)

  1. Moclobemide (RIMA)

Ineffective Dose: 300 mg/day (FAILED vs placebo)

Real Effective SAD Dose: 600 mg/day

LSAS Effect Size: g: 0.23

Mechanism / Outcome: Reversible MAO-A inhibitor. Noyes et al. showed 300 mg/day was no better than placebo. Reaching 600 mg/day is mandatory for measurable LSAS gains.

  1. Fluoxetine (SSRI)

Starter/Low Dose: 10 mg/day

Real Effective SAD Dose: 20 – 60 mg/day

LSAS Effect Size: SMD: -0.38

Mechanism / Outcome: Statistically significant, but raw effect size is weaker compared to other top SSRIs.

  1. Fluvoxamine (SSRI)

Starter/Low Dose: 50 mg/day

Real Effective SAD Dose: 150 – 300 mg/day

LSAS Effect Size: SMD: -0.42

Mechanism / Outcome: SSRI plus σ1σ1​ agonist. Requires high end dosing to work. Nausea and CYP enzyme interactions can be limiting.

  1. Sertraline (SSRI)

Starter/Low Dose: 50 mg/day (starter titration only)

Real Effective SAD Dose: 150 – 200 mg/day

LSAS Effect Size: g: 0.43 (Response Ratio RR: 1.28 to 1.65)

Mechanism / Outcome: 50 mg/day is a titration step. Flexible dose trials show response requires pushing to 150–200 mg/day for social anxiety.

  1. Duloxetine (SNRI)

Starter/Low Dose: 30 mg/day

Real Effective SAD Dose: 60 – 120 mg/day

LSAS Effect Size: Significant vs placebo

Mechanism / Outcome: Dual serotonin and norepinephrine reuptake inhibition demonstrates solid efficacy.

  1. Venlafaxine XR (SNRI)

Starter/Low Dose: 75 mg/day (acts as pure SSRI)

Real Effective SAD Dose: 150 – 225 mg/day

LSAS Effect Size: g: 0.45 (-11.72 points on LSAS vs placebo)

Mechanism / Outcome: At 75 mg, it only hits serotonin. Norepinephrine reuptake (necessary for SAD) kicks in around 150–225 mg/day.

  1. Escitalopram (SSRI)

Starter/Low Dose: 10 mg/day

Real Effective SAD Dose: 20 mg/day

LSAS Effect Size: g: 0.47

Mechanism / Outcome: Head-to-head trials show 20 mg/day clearly beats 10 mg/day and Paroxetine 20 mg/day with high tolerability.

  1. Paroxetine (SSRI)

Starter/Low Dose: 20 mg/day

Real Effective SAD Dose: 20 – 50 mg/day (50 mg/day optimal)

LSAS Effect Size: g: 0.49 (-39.1% LSAS drop at 50mg vs 17.4% on placebo)

Mechanism / Outcome: The most thoroughly researched SSRI for social anxiety. Pushing to 50 mg/day gives the strongest effect among all SSRIs.

TIER 3: GABA Modulators, Calcium Channel Ligands & NaSSA (High Efficacy)

  1. Brofaromine (RIMA)

Real Effective SAD Dose: 150 mg/day

LSAS Effect Size: g: 0.66

Mechanism / Outcome: Reversible MAO-A inhibitor with marked reduction in social avoidance. Unfortunatly development was halted (not commercially available).

  1. Pregabalin (Gabapentinoid)

Ineffective Low Dose: 150–300 mg/day (FAILED vs placebo)

Real Effective SAD Dose: 600 mg/day

LSAS Effect Size: LSAS -29.8 vs -19.7 placebo (p: 0.0099)

Mechanism / Outcome: Feltner et al. showed 150 mg and 300 mg failed to separate from placebo. 600 mg/day is required for efficacy in SAD.

  1. Gabapentin (Gabapentinoid)

Starter/Low Dose: 300–900 mg/day

Real Effective SAD Dose: 2,868 – 3,600 mg/day (Trial avg = 2,868mg)

LSAS Effect Size: ES: 0.78

Mechanism / Outcome: Bioavailability drops as dose increases, requiring high doses to cut fear (3x vs placebo) and avoidance (2x vs placebo).

  1. Mirtazapine (NaSSA)

Starter/Low Dose: 15 mg/day (just sedating)

Real Effective SAD Dose: 40 mg/day

LSAS Effect Size: SMD: -0.80

Mechanism / Outcome: At 15 mg it functions primarily as an antihistamine. 40 mg/day is needed for α2α2​ blockade and monoamine release (based on small trial samples).

TIER 4: Maximum Efficacy (The Heavy Hitters)

  1. Bromazepam (Benzodiazepine)

Starter/Low Dose: 6 mg/day

Real Effective SAD Dose: 18 – 36 mg/day

LSAS Effect Size: SMD: -0.85

Mechanism / Outcome: Substantial raw drop in LSAS scores, but carries high risks for tolerance, cognitive dulling, and dependence.

  1. Clonazepam (Benzodiazepine)

Starter/Low Dose: 0.5–1.0 mg/day

Real Effective SAD Dose: 2.4 – 3.0 mg/day (Davidson trial standard)

LSAS Effect Size: SMD: -0.96 (ES: 0.97, Response Ratio RR: 4.03)

Mechanism / Outcome: Quadruples clinical response rate (78% vs 20% placebo). Rapidly suppresses anticipatory anxiety, but carries high dependency risk.

  1. Phenelzine (Irreversible MAOI)

Starter/Low Dose: 15–30 mg/day

Real Effective SAD Dose: 60 – 90 mg/day (Optimal = 90 mg/day)

LSAS Effect Size: g: 1.14 (ES: 1.02, SMD: -1.28)

Mechanism / Outcome: The absolute highest raw efficacy recorded for social anxiety. Desensitizes amygdala hyper-reactivity. Requires a low-tyramine diet.

Key Clinical Takeaways

The Underdosing Issue in SAD:

People remaining on 300mg Moclobemide, 150mg Pregabalin, 75mg Venlafaxine, or 50mg Sertraline are often receiving placebo-level dosing for SAD. These drugs require titration to upper limit ranges to achieve clinical efficacy.

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u/Dry_Jello2272 — 28 days ago