So, after the full release of the TRIUMPH-1 & 2 data after EASD last week. I've painstakingly updated the beginner's guide with lots of key points and data to pore over, and I even hit on more of the 'common' questions being asked here.

And before you ask, yes, I used Claude (easier to say this than Hermes, which isn't as widely known, but Opus was the agent used) because fuck no, I wasn't gonna design all those updated slides after writing the points and then auditing them for scientific backing. Also used it to summarize a freaking 800+ page protocols document? Because MEGA fuck that. (Although I did go back and skim through half of the protocol stuff; pretty fun read if you have the time)

As always, still open to constructive criticism. Yes, you actually need to have something other than "ew, it's AI-generated; I don't wanna read it." as a response because one thing you shouldn't be able to do is find a peer-reviewed rebuttal.

Trash online from random anecdotes? I almost guarantee it, but the guide lives in a world of documented goodness meant for harm reduction. So deal with it.

ANYWHO with that out of the way.

Sub Updates!

The Mod team quietly updated the rules a bit after much deliberation. Like alot of things, it's give and take here:

• No sourcing, vendors, or sales (permanent ban)

Don't name, abbreviate, hint at, or link any seller of retatrutide or other peptides, including "research peptide" sites, compounders, Telegram/Discord/WhatsApp groups, group buys, and vendor-linked test results. No "DM me", "check my profile", or asking where to buy.

Relatively unchanged.

• Be kind

No bullying, harassment, or shaming of anyone's body, weight, dose, progress, or choices.

Personally, not my choice on wording, as this can/will lead to folks trying to justify poor titration schedules, then coming back about heavy sides (it has happened) but like I said 'give and take'

• Share your experience, not instructions

Your own experience is welcome. Don't tell others what dose to take, to follow a protocol you made up, or to severely restrict calories. Asking "is this normal?" is fine. Retatrutide is not FDA-approved - talk to a doctor about your health.

Note: This is largely still in debate, as it touches more on the stuff I said after 'Be kind,' but giving it a trial run first. Above all. it's the whole "please add your Reta use" when people post pictures/updates/etc. part that should be added.

• No misinformation

Claims presented as fact about safety, effects, or studies need a credible source: published trial results, ClinicalTrials.gov, Eli Lilly, the FDA, or a reputable news outlet. Miracle claims, fearmongering and conspiracy theories will be removed.

This was a give I was not budging from. Misinformation will NOT be tolerated.

• No social-media reposts

No reposts, screen recordings, or links from TikTok, YouTube, Instagram, or Facebook influencers. Links to reputable news outlets and journals are fine.

This was largely an anti-bot thing; luckily, we've only had like...maybe 3-4 hard social media reposts here.

• Stay on topic

Posts must be about retatrutide: trial news and results, research, experiences and side effects, and comparisons with tirzepatide, semaglutide and other incretin drugs.

This one's a middle ground. Lemme address the big sore point here: being 'another GLP-1 drug to Reta', there isn't any official transition dosing, and the best community one is a picture someone drew up on a notepad (For the LIFE of me I cannot find that Pic tho, someone be a mensch and find it for me)

• Follow Reddit's Content Policy

Reddit's sitewide rules apply here too.

And I mean this goes w/o saying so, yeah, no change here.

---

So yeah, have fun with that.

I've updated the guide, I'm currently fighting sleep.

Lots of updates, some additions. I'll update this post with like a full revision list after I sleep or something.

If there are some grammar edits lemme know, I'll go back and fix them. If there's incorrect data, you better have the correct data on hand to correct it cuz if you just gonna chat shit I'm just gonna ignore you

Anyway yeah

Insert thumbs up gif I like to use here.

ps, u/zanza89 it's cuz I do things like this why I got here, maybe next time don't try to sneak diss and actually contribute way more than criticism and unsupported-by-science points.

Pps: I'll try to throw together a summary of the trials data. The bulk of which is in the supplemental and protocol data. So uh gonna need more time to chew through those to pick out points

After weeks/months of nagging and data refining, PTDS has finally officially released thier Reta degradation data.

It is robust and worth a full read. Idk how I'm gonna condense this for the guide, but I will, and I'll add it.

Enjoy.

Also, for those who kept nagging about "Oh, where's your Data??"

Here.
Here is the data.

Hope it gives you all the closure you want.

STEP 1: The Search Bar Reality Check

"Have you typed your question into the search bar?"

❌ "No, because my situation is completely unique and nobody has ever experienced this before."

🛑 DECISION: DO NOT POST.

Reality Check: It isn't unique. You are not a medical anomaly. Your exact question about "fatigue on week 2," "how to use a peptide calculator," or "stall at 2.5mg" has been asked 4,000 times this month. Go to the top right corner, use the search bar, and read for 5 minutes.

✅ "Yes, I searched, read 10 previous threads, checked the pinned guides, and still have a genuinely novel question."

👉 Proceed to Step 2.

STEP 2: What is your actual topic?

Path A: "Where do I buy this?" / "Is Vendor X legit?" / "DM me your plug!"

🛑 DECISION: INSTANT BAN.

Reality Check: Reddit’s TOS and Sub Rule #1 strictly prohibit sourcing. The mods will ban you, and Reddit admins will nuke the sub. Go back to forum boards and learn how to use search engines.

Path B: "My heart rate is 180 bpm and I’m throwing up blood, should I take my next dose?"

🛑 DECISION: DELETE REDDIT, GO TO THE ER.

Reality Check: We are an unhinged collection of anonymous internet strangers playing home-chemist, not board-certified cardiologists. Call emergency services.

Path C: "I injected 0.5mg 20 minutes ago and I'm not skinny yet. Is my vial bunk?"

🛑 DECISION: DO NOT POST.

Reality Check: Pharmacokinetics take time. Pharmacodynamics take longer. Stop staring at the wall, go touch grass, and wait for the drug to absorb.

Path D: "Can I reconstitute this powder using tap water, contact solution, or vodka?"

🛑 DECISION: DO NOT POST.

Reality Check: Buy actual Bacteriostatic (BAC) water. Stop trying to speedrun sepsis. Read the pinned guide in the sidebar before you give yourself an abscess.

Path E: "Can I stack Reta with Tirz, Sema, Cagri, and 400mg of caffeine?"

⚠️ DECISION: PROCEED AT YOUR OWN RISK.

Reality Check: Your heart rate and GLP-1 receptors are fighting for their lives. Half the comments will call you a pioneer, and the other half will draft your obituary.

Path F: "Why can't I handle alcohol anymore?" / "Two sips of a seltzer gave me a 3-day hangover, is this the Reta?"

🛑 DECISION: DO NOT POST (PROCEED TO STEP 1).

Reality Check: Delayed gastric emptying coupled with blunted central nervous system reward pathways means you get zero buzz, all the nausea, and a hangover that feels like a surgical strike on your liver. Congratulations, your tri-agonist turned you into a permanent designated driver. Drink an electrolyte packet and move on.

Path G: "Here is my 6-month Progress Picture along with my exact starting stats, dosage titration schedule, side-effect log, and diet/exercise routine."

✅ DECISION: APPROVED TO POST.

Reality Check: 90% of the comments will ignore the meticulous 500-word write-up you spent an hour drafting and simply comment, "What dose did u start at?" or accuse you of adjusting the lighting in your after-photo.

Path H: "Deep-dive question regarding GIP/GLP-1/Glucagon tri-agonist binding affinities, receptor Ki values, or half-life kinetics."

✅ DECISION: APPROVED TO POST.

Reality Check: You will successfully summon two actual biochemists and forty bro-scientists who skimmed a single Wikipedia article on G-protein coupled receptors. Prepare for a heated 150-comment debate on energy expenditure vs. glucagon agonism.

Path I: A well-documented log with lab analysis, proper peptide calculator math, realistic timeline goals, and zero vendor names.

✅ DECISION: APPROVED TO POST.

Reality Check: Your high-effort post will receive 6 upvotes, zero awards, and 15 private messages from brand-new accounts asking, "Bro where'd u get it text me."

You thought I wasn't gonna add in your suggestions?!

You thought wrong!

The videos have been fixed

Now you folks can enjoy watching them over and over again.

Please lemme know if they don't show

Hi, as some of you kind folks have mentioned to me, Petide Critic got nuked on YT (another reason why playing within the rules is key: here today, gone tomorrow can happen to anyone, so why not reduce the odds).

I'm following along in his community, and it seems like he's gonna re-host them elsewhere, so for now I'll remove the links and put in some placeholder videos. I've already found one or two, but if you want to suggest some, know they must meet these criteria. (To be fair, PC got a pass on one of these rules because of the straightforwardness, but I'm keeping to these criteria)

1. They must not sell product. Not saying they can't have merch; that's fine. But peps? No. Not in any way, shape, or form.
2. They gotta be straightforward, no fluff to hit YT quotas.
3. (And I can't believe I gotta say this, but hey, gotta lay all the cards out there) They have to actually know what the fuck they're talking about.

So yeah

AI creators are okay as long as they actually know what the absolute fuck they're talking about

Yeah, no fuck that part. They should also physically do each step they're teaching.

If your post gets auto limited, that is NOT a signal to try it again or change wording or do it in another language or login to new account to post it or whine and effing complain in my inbox.

Hi hello hi I'm holding your hands and giving CRAZY eye contact as I say this, it's reddit, the platform, doing this. Mods have to approve the messages.

The more you spam, the harder the system locks you. It's the whole Chinese finger toy thing.

So just stop. And wait. Yes i know waiting is hard because your question is soooooooOOOOOOOooooo unique (*scoffs*) we'll get to it.

I'm way less inclined to approve if you spam.

Use it.

That is all.

Please do ask all your burning (and repetitive... So... So repetitive) questions and get it out your system

We're back to business (meaning these questions and discussions will be reference points) tomorrow.

-throws meaningless confetti-

Edit: Lemme also add that is not all repeating questions, there are a few nuggets of good and decent conversations that are going on but they're 'diamonds in the rough'

But if you can search for your question and hit like 100+ posts.... Yeah you're not pushing much forward.

Yes.

I'm gonna build out a wiki for us but first, yes, we have been limiting the mountain of common question

Why? Because we also know (and have evidence of) AI bots constantly sending the same slop questions in order to weasel around. While I don't fully get the why, they exist.

So to actually keep information as fresh for newcomers, we're making the weekends less 'restrictive' and allowing all your questions to be asked and answered (regardless of how stupid I may personally think they are)

<Daily snark counter: 1>

That isn't too easy that outside of that they ain't be, just gotta be a tad more on the unique side you know.

Looking forward to expert opinions and the deluge of questions

*(I'm supposed to say that, right??)*

PS It should go without saying that if you ask for sources or mention vendors, you're getting the big bannerino.

I see it.

Y'all are annoying.

Doing the same post in another language will certainly not help, if anything I'll be petty and remove both for doing that.

Also questions that are answered by the guide (unless it has some unique situations) will also get cut.

Trying to cut down on the "low information" posts.

(also this is a test that I'm running for the rest of the week)

Edit: I love swinging the ban hammer. I'm like Thor with it, so please give me more reason to swing it (don't actually do this, I'm just saying that i also enforce rules)

I’m going to start injecting my body with mysterious chemicals I read about once, because I heard they were good for X

Does this sound like something you were about to post? Because if this is your level of understanding before coming to this subreddit please keep looking for the answer elsewhere. If your question is so simple as “starting dose” or “is this safe” or “will this peptide be good for me”, then you should keep researching. You’re going to be met with sarcasm and not even be able to recognize it, and it’s going to mess you up.

GLP-1s - know your starting dose with confidence, know how many milligrams OR micrograms it is. Know how units are not the same. Know about reconstitution and how you control how “concentrated” a peptide is. Know all of these things before coming here.

Any peptide that you can get levels checked for before starting, such as growth hormone peptides, get tested first.

Peptides are relatively safe, and I know when you first discover them and hear about all they can do you’re eager to get started, but for the love of god you made it your whole life without them. A week of extra research won’t kill you.

Did I steal this from the peptide sub absolutely, will I credit the original poster. Absolutely, u/sonofabunch take a bow

https://preview.redd.it/yw6oarman27h1.png?width=2730&format=png&auto=webp&s=37a0da9e09593c520d2ccf9ce0d4428bbdd07b19

Because I fear you guys have VERY LITTLE confidence in your own calculations. I have added the instructions for using the Peptide calculator site linked in the guide.

I pray this reduces the silly "did I calculate/dose correctly??????" questions.

Also this is a notice to people that the guide DOES get actively updated.

(I have very low expectations on this)

Eli Lilly announced today that their oral weight-loss pill Foundayo (orforglipron) helped women lose significant weight across all stages of menopause — pre, peri, and post.

https://preview.redd.it/e9drcrsx0w5h1.png?width=922&format=png&auto=webp&s=8cc5cca1fa64da29b723af6f24c53ac5bd7920b3

The data comes from two large clinical trials:

• ATTAIN-1 — women without diabetes lost around 12–14% of their body weight (~28–30 lbs) over 72 weeks
• ATTAIN-2 — women with type 2 diabetes lost around 9–14% (~18–28 lbs) over the same period

Women also saw meaningful reductions in waist size — up to nearly 5 inches in some groups.

What makes Foundayo unique is that it's the only oral GLP-1 medication you can take without food or water restrictions, once daily.

Key warnings to know:

• Possible thyroid tumor risk
• Don't use it with other GLP-1 drugs
• Can cause nausea, constipation, diarrhea
• May reduce the effectiveness of birth control pills
• Not recommended during pregnancy or breastfeeding

These findings were presented at the American Diabetes Association's 86th Scientific Sessions on June 7, 2026.

(Yup, I did another Claude-chan summary and threw on the data table, Source: https://investor.lilly.com/news-releases/news-release-details/lillys-foundayo-orforglipron-only-oral-glp-1-taken-without-food)