u/FlyAdventurous6231

Ive checked out, i cant forced users to read warnings and guides. Im passing it on to you to warn others.

7OH wd is intense but short, suboxone withdrawal due to improper rapid doses OR long term use is a much longer withdrawal and soul suckingly bad. If you a prone to depression and alike you need to be very careful. Just read /r/suboxone

It doesnt have to be if you use it correctly

Some cannot do it right due to their mental addiction OCD dosing needs so they need the shot, but the shot and high doses are not designed for 7OH abuse issues.

Youre life your choice, but so many would not take the stupid dosing amounts if they were educated about how they WILL pay the piper for letting your body get use to subs or high dosing rapid detoxing (youre just delaying worse wd with high dose rapid 8 12 16 24 32)

This is my final post on this topic. Some just have to learn the hardway.

Youre most likely not anywhere near the need for subs that an IV / fent / street dope user has.

Ive been wrong about the sub ceiling dose, but you never want to go over 2mg after day 2 IMO and many others. 0.5 MG can help you get by day 3 and easily feel good on 0.25mg

Bupe is a POWERFUL opioid. Its extremely potent and builds up in you due to very long halflife.

• 0.25 use to get me high if i was only using leaf, like nose itching high * you gotta respect the power of this drug or itll own you.

THIS IS MY OPINION through my own life and through others ive been close to (A LOT), I am not god, i am not a doctor, i am an addiction counselor for work. We all have different needs, addiction is never one size fits all.

Ive decided to make this subreddit more liberal and open

Needed to find more help and we good now

Good luck

We are more community ran now

You guys be easy plz

You got this.

Welcome back jake

QuickMD is now supported and can do an AMA

We are not affiliated with anyone or anything, we have no profits or income from reddit or anywhere.

Vent all you want now.

Reddit is a public toilet were no one flushes their poop and no one cleans it while demanding more. We are migrating off it.

Victory was / is ours. Time to focus on building a community away from reddit.

If you have a good histort and want to be a mod message me

Adding more mods then we will open up again. None of us want to nor have the time to keep up anymore.

Looking for 5 new mods who will be vetted

Most of us still around have agreed the best thing we can do is freeze good info, lock out the 7hydro sub reddit kids and the 99% who just read can still get all the info needed. The 1% that post dont outweigh the need of the million who came here last 30 days who 75% of the time get met with negative hate, misinformation, junkie rage.

We arent paid to do this, this is the best path forward for the bulk of the community.

Our discord is lightyears ahead of the subreddit socially. Why? They cant get away with what they so easily can do on reddit.

Its over johnny.

7OH is just a name, they exploit you with lies and marketing.

This is why they listened to this group over the pro 7hope people. We have facts and science behind us. We won. Our tiny team of 3 helped kick ass honestly.

Here is a tiny mixed post of info for those unaware of what they were taking.

You are withdrawaling from hydrogen bonded oxidized minor alkaloids that have never been eaten by humans before, have no ISO references to test for, NONE of them show up on tests that show how much 7OH mg is there.

We know the potency can rocket in horrible ways when you add a hydrogen bond, faster acting faster leaving and more misery when gone.

Not only dont they know or test but they dont even test for the 10hydroxy

Hydrogen bonded specto as well as 7-10 other kratom alkaloids Omg. They know you dont know they dont convert 100℅ MIT isolate to make pure 7OH. They screwed you lied to you for $ and to get you hooked like a corner boy does.

This is why you get trauma from this wd, youre hit on all angles. Its not like withdrawaling off morphine, its way worse

We do know the best cocktail to fix the sickness is subs 0.5mg wvery hour till 2-4mg and take 2-5g of leaf to calm all the non opioid alkaloids wd.

This is why filling your receptors just with another opioid doesnt work for most first few days.

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YOUR ON A COCKTAIL. ALL OF YOU. Some way worse than others. The darker and cheaper the more polluted it is.

7-Hydroxymitragynine (7-OH) — the well-known, much more potent opioid-active oxidation product of mitragynine (formed in vivo and also produced by laboratory oxidation). This is the most important oxidized product from a pharmacology/safety perspective.

7-Hydroxyspeciociliatine — an analogous 7-hydroxy product derived from speciociliatine (reported in older phytochemical reports).

Mitragynine N-oxide and other N-oxides — commonly observed oxidative metabolites in profiling studies.

Mitragynine pseudoindoxyl (pseudoindoxyl rearrangement products) — reported as a rearrangement/metabolite with distinct receptor pharmacology in some studies.

Hydroxylated or oxygenated variants of other minor alkaloids (e.g., oxidized corynoxines or speciogynine derivatives) have been detected or synthesized in analytical chemistry work.

There are many more, these are the only ones currently barely being looked at. They can be EXTREMELY more potent than their original form. This is why there are so many crazy side effects.

Most people who cant pee on opioids are on very high IV doses. To take 7oh and not be able to pee means youre just as high as the dude shooting heroin passing out on the toilet.

Many report kidney issues and liver enzyne spikes. Probably from all the chemicals used to make this stuff and the solvents. Majority of labs are pumping it out so fast they barely roto vap it to clean it. They only do jist enough to get out what they know is commonly tested for.

Just because you dont death nod doesnt mean its weaker.

All the labs test for the minors in their non oxidized state. So theyre tricking you to think its only 7oh with maybe some psuedo. These same people told us at first 7oh had little withdrawals as a selling point in 2023

MG = mitraygnine

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NO product is the same, harsh chemicals are used in 4 stages, each stage different, toxic, many oxidize with commercial pool products.

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No one has the same withdrawals. Its unpredictable as nothing is pure, clean, regulated. Nothing. Every batch is different.

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Its a cocktail of alkaloids oxidized into extemely more potent forms not ever used by humans before

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You withdrawal from multiple channels of function in your brain and body

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Opioid kappa (nasty wd, subs do this too, is a part of why 7oh, bupe, have such a depressing wd)

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binds with high affinity to the µ-opioid receptor (MOR). For example, one study reports a Ki for 7-OH at MOR around \~16 nM, significantly stronger than for MG.

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It shows measurable binding to the κ-opioid receptor (KOR) and δ-opioid receptor (DOR), though with lower affinity compared to MOR. For example: Ki for KOR \~220 nM (versus \~78 nM at MOR) in one dataset. You get classic opioid wd + more pronounced kappa which is thought to cause the depression and apathy much more than other opioids, again bupe is like this too and why users mentally have such a hard time getting below 1mg. Mentioning this to show how much different 7oh is compared to other fast acting pleasurable opioids.

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Calcium channels (feels like phenibut, lyrica, baclofin wd in ways) this wd gives shakes, anxiety, panic, primal fear.

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Endocrine disruption (ovaries, testicles, adrenal glands, pituitary) your hormones go out of wack, period loss, low T, gyno man boobs, hair loss, always fatigued, cravings for sugar)

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Most people who take it every day glow under UV light. Lots of bs here of people defending this as it can happen from other thinga, but very common with 7oh users. There is something to this, harmless or not we dont know.

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Extreme dopamine and endorphin down regulation. Most are zombies except their first dose of the day. Some people get excited to wake up in withdrawal as its the only time they really feel pleasure with that first dose

Waking up hours into sleep with RLS even in your arms and shoulders (remember that youll only fully recover this fatgiue and lack of motivation with exercise, no drug will fix it, only will burn you out more, like taking wellbutrin without exercising, youll only end up worse after a motivating spike) *youre not burning off all the extra norepinephrine, wellbutrin is forcing reuptake, this can cause side effects, anixety jitters, stimulated yet cant get motivated to move. Much more but this is off topic.

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This is why even after you quit you have no desire to do anything, no pleasure in doing tasks, no joy, no energy. If you then start eating bad then doom scroll all the time or video game all the time because your so BLEH and flat... Youre going to be faced with major depression and want to relapse to fix it. Dont, of course, if all else fails ... Leaf can cure the minor alkaloid wd depression, dont use it past day 5. Leaf is very mentally addictive and just plain bad for your body to process everyday.

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Anger and extreme irritability

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SNRI withdrawals, typically get all the side effects from that even at low dose.

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YOUR ON A COCKTAIL. ALL OF YOU. Some way worse than others. The darker and cheaper the more polluted it is.

​

7-Hydroxymitragynine (7-OH) — the well-known, much more potent opioid-active oxidation product of mitragynine (formed in vivo and also produced by laboratory oxidation). This is the most important oxidized product from a pharmacology/safety perspective.

​

7-Hydroxyspeciociliatine — an analogous 7-hydroxy product derived from speciociliatine (reported in older phytochemical reports).

​

Mitragynine N-oxide and other N-oxides — commonly observed oxidative metabolites in profiling studies.

​

Mitragynine pseudoindoxyl (pseudoindoxyl rearrangement products) — reported as a rearrangement/metabolite with distinct receptor pharmacology in some studies.

​

Hydroxylated or oxygenated variants of other minor alkaloids (e.g., oxidized corynoxines or speciogynine derivatives) have been detected or synthesized in analytical chemistry work.

​

There are many more, these are the only ones currently barely being looked at. They can be EXTREMELY more potent than their original form. This is why there are so many crazy side effects.

​

Most people who cant pee on opioids are on very high IV doses of full opioids(diluadid, etc). To take 7oh and not be able to pee means youre just as high as the dude shooting heroin passing out on the toilet. Yeah sounds harsh, but your just not getting as much CNS depression, you get a high like many semi synthtic opioids converted from thebaine give.

BUT** this year people have started nodding and puking in their sleep on 7OH products waking up in ER asperated. We have posts here reporting it.

​

Many report kidney issues and liver enzyne spikes. Probably from all the chemicals used to make this stuff and the solvents. Majority of labs are pumping it out so fast they barely roto vap it to clean it. They only do just enough to get out what they know is commonly tested for.

​

Just because you dont death nod doesnt mean its weaker.

​

All the labs test for the minors in their non oxidized state. So theyre tricking you to think its only 7oh with maybe some psuedo. These same people told us at first 7oh had little withdrawals as a selling point in 2023

​

Writing this due to seeing so many arent even aware how serious of a drug cocktail theyre on. So many poor souls thinking they can stop with just some MIT. You are no different than the person who is hooked on street dope. Youve been tricked because of the partial aspect of not nodding. However, psuedo people can nod out

7OH causes horrible opioid rage and being always irritated. ALL kratom opioid alkaloids caused it in me when i used. I hated it so much.

Back in the 30s 40s people in germany would end up in a mental hospital due to this rage people didnt understand

I knew fast acting opioids cause rage as they wear off but the history of it via oxycodone is crazy wild and heavily documented before the war on drugs happened. Now doctors dont even warn you or your wife/husband what this shit is going to do to your mind body and soul if not aware to combat it

Why isnt it talked about much anymore or solutions found?

Who here feels irritable anger more than relief after using it? Why dont opioids with long half lives cause it chronically unlike short acting? Probably the rapid hormone shifts, stress hormones, and lack of dopamine after a huge burst?

The biology of opioid-related irritability, anger, and aggression centers on neuroadaptations in brain reward, stress, and emotional regulation circuits—especially during withdrawal and chronic use. These changes produce a heightened negative emotional state (hyperkatifeia) that lowers the threshold for irritability and can facilitate aggressive responses.

pmc.ncbi.nlm.nih Core Framework: Opponent Processes and Hyperkatifeia Acute opioids (via µ-opioid receptors, or MORs) strongly activate reward pathways, particularly the mesolimbic dopamine system (ventral tegmental area → nucleus accumbens). With repeated exposure, the brain engages opponent processes that counteract this: reward systems are downregulated while anti-reward/stress systems are upregulated. The result is hyperkatifeia—an intensified negative emotional/motivational state during withdrawal or abstinence that includes dysphoria, anxiety, irritability, emotional pain, and restlessness. This state is distinct from purely somatic withdrawal symptoms and strongly motivates further drug seeking via negative reinforcement.

pmc.ncbi.nlm.nih Key Brain Circuits The extended amygdala is central. It includes the central nucleus of the amygdala (CeA), bed nucleus of the stria terminalis (BNST), and nucleus accumbens shell. These regions process stress, fear, anxiety, and negative affect and become hyper-responsive after chronic opioid exposure.

pmc.ncbi.nlm.nih Within-system adaptations (reward side): Reduced dopamine signaling in the nucleus accumbens (hypodopaminergic state) contributes to anhedonia and negative mood. Endogenous opioid peptide (enkephalin/endorphin) function also declines.

Between-system adaptations (stress side): Recruitment of pro-stress systems, notably: Corticotropin-releasing factor (CRF) in the CeA and BNST. Opioid withdrawal elevates CRF release; CRF drives anxiety-like and aversive states.

Dynorphin / κ-opioid receptors (KORs). Dynorphin (the endogenous KOR ligand) is upregulated. KOR activation suppresses dopamine release, produces dysphoria and aversion, and contributes to both hyperalgesia and hyperkatifeia. KORs also modulate serotonin (5-HT) release.

Norepinephrine from the locus coeruleus and other inputs, amplifying arousal and stress reactivity. Additional contributors include glucocorticoids, hypocretin/orexin, and neuroimmune signaling. These changes create a sensitized “negative valence” network that makes ordinary stressors more aversive and lowers tolerance for frustration.

pmc.ncbi.nlm.nih Serotonin, Social Behavior, and Aggression Links Protracted opioid withdrawal can impair sociability and increase aggressive-like behaviors (shown in rodent models with long-lasting effects). One mechanism involves dynorphin release from dorsal raphe neurons acting on KORs on serotonin terminals in the nucleus accumbens shell. This blocks the normal rise in 5-HT that supports prosocial interactions, contributing to social deficits and potentially to irritability or hostility. Serotonin dysregulation more broadly is linked to impulsivity and aggression across many conditions.

ScienceDirect Prefrontal cortex (PFC) executive function is also impaired by chronic opioids, weakening top-down inhibition of amygdala-driven emotional responses. This reduces impulse control and increases the likelihood that negative affect is expressed as anger or aggression.

Hormonal Contribution Chronic opioids suppress the hypothalamic-pituitary-gonadal axis, producing opioid-induced androgen deficiency (especially low testosterone in men). Low testosterone is associated with irritability, fatigue, and mood disturbance, adding a peripheral endocrine layer to the central neurocircuitry changes.

Dont stay on kratom leaf

Itll seem mild but it has all those other alkaloids that cause a really rough antidepressant exhausted all day withdrawals. Just a reminder. Youre never fully recovered till its all out of you so remember that when subs / leaf comfort you. This was very hard for me to control for awhile. Leaf wrecks my digestion, i abused it for awhile, its like galbladder / liver enzymes struggle to break it down under most circumstances. Puked up leaf. probably 200 times in my life. Its a nasty habit to form taking leaf all day. Leaf extracts get closer to quitting hydro levels of pain.

Step off within 5 days if youre using it to come off 7 or pairing with subs for worst cases.

It goes without saying sub withdrawals are the longest and worst paws if you get use to it. Rapid is the way unless you cannot get your life together, only you know, we cant tell you your needs.

Rip the bandaid off today. Dont be in the same place next friday.

Theyre of course dumping old rejected stock for last pile of money.

Old, moldy, solvents not vaporized off, oxidizers not rotovap. Itll make you really sick, makes weans feel shit, make you wonder why youre high yet sick or sick cant get "high"

99% of these vendors are predatory, the smoke shop grey drug market types are pretty scummy in general.

Be careful. You only get one body, one brain. Trauma comes in many forms with low healthy lifestyle + drugs, these arent purified 99.9% purity pharma drugs. Only like 3 of MANY labs are "professional" . all 3 shutdown months ago.

Most of these tabs were converted 70% MIT and pressed in rented storage facility rooms with zero effort to keep clean.

Be careful.

Remember, you dont have to go to street dope, if you do thats your choice no one forced it upon you. Freewill, suboxone exists and its not gonna get you high, sorry. But it will give you time to take control of your life back. tough choices need to be made. Dont give in, jails, institutions, or death are the results of that path.

Prepare for the desire of relapse. NO IDLE TIME. Boredom is your enemy. Go walk the woods for 8 hours if you have to.

You have to want it, cant pine away in self pity, you have to walk through thorns to get to the field of wildflowers and sunshine. Its worth it!

Dont get lost in the fear porn reddit is so good at making.

Youll be fine. We have stickied all your resources, flairs, quitting7oh.org

If you dont use these resources youre shooting yourself in the foot.

I have adjusted the filters to high so that at least the fear porn gets pushed into mods before public sees it now. But users always find a way somehow.

Ranting is fine but most posts here past month do NOT help anyone and we are a place for help not your toilet to crap in and not even flush for the rest of us

Youre going to be fine, this is a temporary feeling. Use our acute and paws resources. Make a plan with that info with chatgpt. Itll plan every hour out. Feed it our guides to fine tune them to your needs.

Fear dump on the AI not your fellow human

People want to relate to your struggles but they also want hope. Junkie withdrawals suck bad i know, but a lot of it is how your perception of your situation is. Stay positive and leave the junkie shell of misery behind forever and never look back.

We dont remove these posts dont worry.

There are a lot of kratom meetings on the internet

We also have a discord

I knew first W tab i took in 2024 that this drug is way more potent than advertised. It felt like instant oxycottin and i knew i was screwed but went back and bought the store out because it felt even better than cut heroin on the corner.

Lots of questions if you can do this or that, assume if you cant take, go under, proceedure, etc while being on heroin or morphine you cant do it or shouldnt risk it

No judgement here at all, but youre a dope head and just like the street users you see except your insulated by the fact it doesnt have bad resportory depression.

Lots of people over the years who went deeper in 7OH pseudo have woke up with a tube down their throat at the ER. Ive seen it at work and ive seen posts here as well. Its a serious addiction and no different than getting hooked on sniffing heroin. Only difference is you dont pay taxes on heroin buys like 7OH mixes and it wont male you stop breathing by itself (but it has with heavy pseudo mixes as its a full anatag)

Itchy nose, nods, cmon people. Think logically about this as i see some really concerning posts and questions from people who really dont see that theyre on dope.

Junkie, dope head, all feel harsh and offensive but its true and lots of denial or just unawareness. I find it easier to get off this stuff and change your life if you understand where youve been dragged to. This lifestyle is how people who have jobs and families become homeless.

No judgement, just reality. I am or was one.

Id rather withdrawal again from heroin than 7OH full spec. Anyday of the week. Before tthe comments, just because you had poorly converted 7OH or similar and didnt get hit as hard doesnt mean what was stated above isnt the case for the majority.

This is a very serious life altering addiction

On*

Yes sir. Buy liquid forms or high absorbing formulas, cheap stuff poorly absorbs or you poop it out. Majority of you ive ran into to help have malabsorbing issues as do most opioid addicts due to the intestinal receptors.

Triquetra brand is top shelf for these vitamins and the best blackseed oil on the market. I use them everyday and im not affiliated in anyway. I have tried LOTS of brands wasted lots of money, this brand is incredible.

30% of your shitty wd feelings are because for some reason 7OH products end up draining your vital vitamins, iron, testosterone, blah blah. Youll feel better if you hydrate properly, lower your sugar intake (DONT flood your body with sucralose or etc, take this time to rebalance sugar addictions as its very inflammatory which makes acutes last way longer)*

Men, you surely want to try tongkat ali for your potential hypogonadism from 7oh use. Solaray is the brand i use and ive covered this in the past. Itll wake up your balls for lack of desire of deep explaining how it works. Made me feel a lot better and producing much bigger ...loads? Yeah anyways its not all just an opioid receptor issue with opioid acutes and its even more of a larger spectrum of health issues due to all the oxidized alkaloids that work on other areas.

Toodles

P.s i do all this for free i have zero financial gain even with 950k views a month here. So shaddddup in my DMs :D thanks.

You guys drive me crazy that all answers are here and you dont even search our flair / detox guides, dont bother to verify with AI

You just post with your legs up and wait for help to come.

For those that do and dont flood our database with the same god dang questions already answered. Thank you, so much. Makes it better for everyone.

Those that dont, i know your innocent but your posts make it way worse for the majority that dont post. Your panic helps no one and certainly not yourself. Its gonna be ok, just read, just read. Its all here and organized.

Even bold high lighted bright colors sticky posts get ignored.

Please search, the fear porn panic posts make this place worse for everyone. People want to be motivated not cater to you being panic and lazy. We are all the same here, dont be selfish. Rant all you want but stop the same fear based OMG am i gonna die shit. No youre not and weve spent years now crafting easy ways off. Youre screwing yourself not reading through proper flairs and most of all front page sticky posts.

This is a small community, act right, or stay just reading. When im gone.. Trust me no one else is going to care here and itll get wild.

Thanks.

Just fyi

Itll make it way worse and wont help you sleep

Please click here

https://www.reddit.com/r/quitting7oh/s/iB3jTL21cy

Low dose naltrexone and wellbutrin can stop paws for most

Do not take naltrexone till you have no opioids, once off subs needs 10 days clean as subs have long half life

For 7oh need 4-5 days off. You can start with 50-100MCG while opioids fall off to help BUT no more than that till youre clean.

Wellbutrin can be taken whenever.

Ageless RX had LDN, do not mention 7OH or kratom.

Study this to understand how it fixes post acute withdrawal syndrome

https://www.reddit.com/r/quitting7oh/s/DWiE9N6W4g