u/Fritochipteeth

Hey fammmm

I am switching from Zepbound injections to Wegovy in pill form. To overview my journey, I started in May 2024-- at that point weighing 244 lbs. I went on compounded semaglutide until October 2024, and lost about 10lbs in that time period, but had SEVERE side effects after going up and up in dose.

I then switched to compounded tirzepatide, going up to 7.5 MG on the dose for the weekly shots. I then switched to name-brand, zepbound shots in December of 2025, going from 5.0mg to 7.5mg generally in dose. I finally stopped Zepbound in March of 2026, after not losing any weight, essentially in one year of taking it. I am now paused at 229lbs. Basically, I am a mega slow responder, and also wasn't taking it at the dose I should have been on.

I do have to mention that someone with as severe insulin resistance as me should ideally be on the highest dose for these medications, but I could never tolerate more than the middle dose, as even the middle dose would have me blowing out both ends and severe sulfur burps, and any higher would send me to the ER (I had to go to the ER twice when I was on 10.0mg after 30+ movements in 48 hours).

I am now starting on Wegovy pills, as I am ready to commit to calorie counting as well, and responsibly taking it. Just took my first 1.5mg dose today, and honestly feeling decently full. I am at ~1200-1300 calories at 6:00 pm right now.

How has the pill been working for you, if you are switching from injections? Any bit more benign? If you were someone who was on a high dose on injections, what dose are you benefiting from in pill form? Thanks~

Hey guys, I started my simlandi on 05/06, and I am grateful to say for the most part, I was actually a super responder.

For the record, I am not formally diagnosed with AS but suspected AxSPA, high ESR and CRP, HLA B27+ and matching symptoms and pain patterns, flare has been going and progressively worsening since last May. PT, cortisone shots and various other methods did NOTHING only ibuprofen helped.

Basically an hour after taking the shot, all of my pain disappeared— my back and shoulder responded very well and are completely gone pretty much as of 05/13. I have not taken one dose of ibuprofen since the 6th, whereas normally I needed 1200mg just to function, ideally 2000mg would have me feeling “normal” but that was too dangerous to do. My inner feet which were really bad were gone too, but as of a couple days ago, maybe 05/11 my feet came back :(. Back and neck are doing great though! Just today, had to take 400mg of Ibuprofen bc my feet are killing me. :( then again, I did walk 6k-7k steps 2 days in a row in Mary Jane’s.

Is this something that is going to continue to improve as I continue my progress with taking the biologic? Is the dose I’m taking and continue to take every two weeks building up a system essentially to beat my inflammation or is it always going to be that it works for my back and not for my feet? Based on me being a very quick responder how do you think this progress is going to play out from your experiences? Thanks!

Hey yall, I’m a 27F with suspected AxSpa: to overview:

I’m HLA B27 positive, CRP before meds was 24.8 and ESR was 38. I also am 60lbs overweight and have hypermobility. But negative on MRIs for deterioration in SI joints.

Since June of last year (10 months now) I have been having ongoing pains in various parts of my body— started off with feet first, was suspected to be peroneal tendonitis or plantar fasciitis, but MRIs were clear, I tried various shoe changes and nothing worked. PT did not work, only icing and ibuprofen. Then the foot pain changed to the insides of my feet.

Then in August, in addition to my feet, my back (only thoracic) began to act up very badly. Worst in the morning, better with movement + ibuprofen and gets bad with too much movement (beyond 4k steps). Again, PT did not help at all, nor massages, nor heat. Icing somewhat helps and ibuprofen is a godsend. Finally in December in addition to both feet and back pain, my shoulder began to act up as well.

Pain is overall improved since its worst, I’d rank it cumulatively a 5/10– noticeable but functional. I used to have to take 2000mg of Ibuprofen a day just to function, now I take 800mg to 1200mg.

I started sulfasalazine in March, and it’s now end of April— my CRP went from 24 to 16 and my ESR went from 38 to 18, big wins on the labs but I feel no improvment symptom wise. My rheumatologist wants to move me toward Humira instead.

Anyone have experience being nonresponsive to Sulfasalazine or other DMARDs and being responsive only to biologics? Thanks!