u/GeneralNo8471

Hi, ive been supplementing with ND's NKO krill oil softgel. It's been a very long time.

Thing is that I'm reading more and more adverse studies and reports about it and I would like to ask the opinion of the community. Keep or not? Thank you.

"fish oil (omega 3 is highly susceptible to oxidation at body temperature and forms several harmful aldehydes after ingestion including acrolein; these by-products have harmful effects which impede recovery and contribute to potential relapse)

More info on fish oil issues:

Marine oils...contain the long chain polyunsaturated fatty acids (LC-PUFAs) -eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, it is important to understand that...these oils are highly susceptible to oxidation. n-3 LC-PUFAs are chemically unstable, so that marine oils rapidly oxidize during storage to a complex chemical soup of lipid d peroxides, secondary oxidation products, and diminishing concentrations of unoxidized fatty acids. (source

The products of EPA/DHA decomposition include acrolein, malondialdehyde, 4-hydroxy-2-hexenaldehyde, crotonaldehyde

Lipid peroxidation gives rise to carbonyl species, some of which are reactive and play a role in the pathogenesis of numerous human diseases. Oils are ubiquitous sources that can be easily oxidized to generate these compounds...from fish oil... The analytes include highly toxic reactive carbonyl species such as acrolein, crotonaldehyde, trans-4-hydroxy-2-hexenal (HHE), trans-4-hydroxy-2-nonenal (HNE), trans-4-oxo-2-nonenal, glyoxal and methylglyoxal, all of which are promising biomarkers of lipid peroxidation.

Exogenous or endogenous acrolein can exert deleterious health effects due to its high toxicity. Given its highly electrophilic structure, acrolein can easily bind to some nucleophilic biomacromolecules, such as protein and nucleic acids. The binding of acrolein to biomacromolecules results in oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction or even inflammation and abnormal immune responses. (source)

The acrolein which is released during lipid peroxidation inhibits mitochondrial function by poisoning the crucial respiratory enzyme, cytochrome oxidase, resulting in a decreased ability to produce energy (Picklo and Montine, 2001), Besides inhibiting the ability of nerve cells to produce energy from the oxidation of glucose, acrolein inhibits the ability of cells to regulate the excitatory amino acid glutamate (Lovell, et al., 2000), contributing to excito-toxicity."

Hi, ive been supplementing with ND's NKO krill oil softgel. It's been a very long time.

Thing is that I'm reading more and more adverse studies and reports about it and I would like to ask the opinion of the community. Keep or not? Thank you.

"fish oil (omega 3 is highly susceptible to oxidation at body temperature and forms several harmful aldehydes after ingestion including acrolein; these by-products have harmful effects which impede recovery and contribute to potential relapse)

More info on fish oil issues:

Marine oils...contain the long chain polyunsaturated fatty acids (LC-PUFAs) -eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, it is important to understand that...these oils are highly susceptible to oxidation. n-3 LC-PUFAs are chemically unstable, so that marine oils rapidly oxidize during storage to a complex chemical soup of lipid d peroxides, secondary oxidation products, and diminishing concentrations of unoxidized fatty acids. (source

The products of EPA/DHA decomposition include acrolein, malondialdehyde, 4-hydroxy-2-hexenaldehyde, crotonaldehyde

Lipid peroxidation gives rise to carbonyl species, some of which are reactive and play a role in the pathogenesis of numerous human diseases. Oils are ubiquitous sources that can be easily oxidized to generate these compounds...from fish oil... The analytes include highly toxic reactive carbonyl species such as acrolein, crotonaldehyde, trans-4-hydroxy-2-hexenal (HHE), trans-4-hydroxy-2-nonenal (HNE), trans-4-oxo-2-nonenal, glyoxal and methylglyoxal, all of which are promising biomarkers of lipid peroxidation.

Exogenous or endogenous acrolein can exert deleterious health effects due to its high toxicity. Given its highly electrophilic structure, acrolein can easily bind to some nucleophilic biomacromolecules, such as protein and nucleic acids. The binding of acrolein to biomacromolecules results in oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction or even inflammation and abnormal immune responses. (source)

The acrolein which is released during lipid peroxidation inhibits mitochondrial function by poisoning the crucial respiratory enzyme, cytochrome oxidase, resulting in a decreased ability to produce energy (Picklo and Montine, 2001), Besides inhibiting the ability of nerve cells to produce energy from the oxidation of glucose, acrolein inhibits the ability of cells to regulate the excitatory amino acid glutamate (Lovell, et al., 2000), contributing to excito-toxicity."

Hi there, addict in recovery here, been in the nootropic scene and studies for a while. Actually, I was looking for a way to repair the damages I have done during 20 years ot active addiction mainly to alcohol but also to benzos, all types of stims, and opioids. Hence, I ended up in the world of smart drugs, like some call it. I've been able to do a lot of progress but I'd like to reach out to the community for a suggestion. Do you know of a supplement that fights drugs/alcohol cravings? Those can be very intense, painful and risky. The 3 I had known so far but didn't got that many results with were agmatine sulfate and NAC (through NMDA activity here). Also 4dma 7,8 dhf was praised, I guess thru it's BNDF trkb NGF action. That's true that a plant from Africa with an extreme BDNF action is said to cure addicts and even give the opportunity to opioid addicts to get out of addiction without withdrawals and without further cravings. No need of medically assisted treatment either. That's what I've read about this plant and the retreats, as I was myself concerned back then but took the MAT way to exit when I was addicted to opioids. I cannot afford to do such retreat nowadays so it's useless to recommend. So, any of you would have something to suggest? Some will say gym of course, lifting weight and running... of course it's a great idea but my endogenous reward pathway is kinda messed up... so I'm all ears. Thank you!