r/NootropicsDepot

Safralis and Cognance stack - doing the dopaminergic and serotonergic two step dance.

Safralis and Cognance stack - doing the dopaminergic and serotonergic two step dance.

A very effective one two neuronal elixir, which results in a palpable dopamine punch with an additional unique sparkle in cognitive function. Within 45 minutes of taking my first dose of 30mg of Safralis combined with 100mg of Cognance, I was overcome with a warm feeling of joy similar to doing an activity that rings the reward and pleasure bells 🔔 in your brain 🧠. I noticed improvements in my mental focus and attention as well. Together they empowered me with additional motivation to tackle mindless mundane tasks that I would normally put off (vacuuming and laundry, etc).

The dopamine component was the dominant factor in my first and second dose. I did notice that the underlying less noticeable GABAergic effects helped me to fall asleep faster 7-8 hours after my first dose and experience deeper sleep.

The serotonin component mainly from the Cognance added an additional more subtle mood boost, improved verbal mastery, better recall & memory support, and a feeling of enhanced creativity. Cognance whose active ingredient is ebelin lactone adds a M1 muscarinic and 5-HT2A serotonergic layer to the experience which perfectly complements the Safralis experience.

Graduating up to the 30mg Kashmiri Safralis dose from the old formula 30mg Spanish (actually Iranian) saffron dose is very noticeable with a stronger effects profile and more nuanced layers in the mental effects without being too intense or overwhelming. Advisorhead gives the new Kashmiri saffron two thumbs 👍🏽 up and will permanently be incorporating this product in his daily stack.

u/AdvisorHead8533 — 5 days ago

[Product request] Please comment your favorite, ill start

I was curious what everyone's most favored & anticipated product request would be.

For me it would be "ProteoMAX" enzyme blend.

Bromelain, papain, actinidin, serrapeptase, nattokinase, lumbrokinase, catalase. Quercetin works synergistically with some of these, and may be a welcome inclusion.

Another product idea would be "PhenolMAX". A polyphenolic blend of wild blueberry, pomegranate, sea buckthorn, high flavanol cacao, curcumin, coffeeberry, camu camu, tart cherry, black currant, elderberry, chokeberries, green tea extract.

What do you guys think?

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u/AnomalousSavage — 5 days ago

SulfoMax

Finally got to try it. The parcel arrived on Monday, but the Post Office held it for ransom and I couldn't get down there to pay for its release until Friday.

This morning I took one full size scoop and put it in a lukewarm glass of water. Waited roughly ten minutes, then put the water in a blender bottle with a scoop of InfiniGreens. Then added more water to fill the bottle. I've been taking Infinigreens for a couple of months. This is the first time I've tried SulfoMax.

Interesting observation: InfiniGreens is pretty clumpy. It often takes a fair amount of vigorous shaking to get it all off the bottom of the bottle. Not today. The SulfoMax made everything dissolve nicely.

So the effects were pretty remarkable. One the lesser end of the scale my injured thumb stopped hurting and still feels pretty decent. There was some stomach nausea, but it was pretty minor. Moving up in importance, today was rainy and cold and I had to do a lot of walking. I usually get tired, but today I had energy to spare and barely noticed the cold.

Most important were the mental effects. It's hard to describe, but my thoughts were more... intense, focused. I felt great, somehow more "me" than usual. I enjoyed things more, like conversation. Even little snatches of music I heard in passing were fun. Things that might have normally stressed me didn't make a dent.

And for some reason I didn't procrastinate at all today! Instead of thinking about doing things I just did them, and that includes writing this post. It's kind of a huge change for me, and I'm somewhat startled that something like a supplement could change my behavior that much.

I'll take another scoop tomorrow. Hopefully the effects will continue, and not gradually wear off like with most supplements.

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u/kevinstreet1 — 4 days ago

Saffron @ 30mg makes you drowsy/sleepy?

Hello everyone,

I’m new in this sub but have been shopping with and for years now. Glad to have found this group. I have the old saffron not the new version. Are people reporting sleepiness with taking saffron and if so do you typically switch your doses in the evening to help with sleep instead?

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u/therealzyzz — 4 days ago

What's your favorite all-in-one probiotic supplement?

I have InfiniFiber and realize it has prebiotic/probiotic support, but I wanted to also buy a separate probiotic and it doesn't look like ND offers anything?

I was wondering what your favorite all-in-one product is. I'm primarily looking for overall gut health but I deal with anxiety and OCD too, so anything that would help support calm mood and brain-gut connection would be great too. Ideally would like a single product rather than having to buy a bunch of different ones. any suggestions?

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u/paulrudder — 5 days ago

⚠️NEW PRODUCT RELEASE 10/8/26⚠️ Infini-D | Optimized Vitamin D Stack + Infini-K | Optimized Vitamin K Stack + a Mystery Product

Two new products drop October 8th!

Two new products drop October 8th, plus a mystery product. Infini-D: 5,000 IU vitamin D from D3 + D2, with tributyrin. Infini-K: K1, MK-4 and MK-7 in one capsule.

The wait for our next release is almost over. On Thursday, October 8th, Infini-D and Infini-K both go live: an optimized vitamin D and an optimized vitamin K, each built with more than the vitamin alone. They work on their own or together, and we'll share more on pairing them once they're live.

Infini-D | Optimized Vitamin D Stack

Vitamin D supports healthy bones, immune function and a healthy mood, yet most of us get less of it from food and sun than we'd like. Infini-D pairs microencapsulated vitamin D3 and D2 in one formula and rounds them out with three supporting ingredients.

High level:

  • 125mcg (5,000 IU) vitamin D per two-capsule serving, split evenly between D3 and D2
  • 500mg maitake mushroom extract, standardized to 0.5% ergosterol
  • 200mg tributyrin, a stable source of butyrate
  • 5mg L-(+)-ergothioneine

Infini-K | Optimized Vitamin K Stack

Vitamin K helps direct calcium to where your body needs it, which makes it a natural partner to vitamin D for bone health. Infini-K brings a full spectrum of vitamin K into one capsule: K1, the form found in leafy greens, plus both major forms of K2.

High level:

  • 1mg vitamin K1 as phylloquinone
  • 500mcg vitamin K2 as microencapsulated MK-4
  • 100mcg vitamin K2 as microencapsulated MK-7
  • 500mg broken cell chlorella, a natural antioxidant that helps protect the vitamin K from oxidation

Mystery Product

https://preview.redd.it/ny4wyw5bzvsh1.png?width=905&format=png&auto=webp&s=e8f9671173612d855077b6b8139113e72ba11c0b

A third product launches alongside Infini-D and Infini-K on October 8th, and we're keeping it under wraps until launch day. One clue: its story starts in the mountains.

Launch date: October 8. If you want an instant heads-up the moment they go live, you can opt into Email & SMS alerts by clicking here, or keep an eye on our upcoming releases page.

In Wellness,

The Nootropics Depot Team

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u/NootropicsDepotCom — 14 days ago

Almost Zero effect from Black Ginger Extract after 2 months

Title.
The only thing i noticed was maybe it was making the effect of my cistanche a littls stronger, but on its own NADA.

i kept at it thinking that it would do something in the background due to its many benefits claimed on the website. But even then after 2 months, i haven’t noticed any changes.

Anyone had a similar experience?

reddit.com
u/kevessi — 11 days ago

Do the people here trust things like Cerebrolysin, noopept, cortexin in 2026 or not really?

You'll have Japan not approve Cerebro but South Korea approve.

Germany approve but not Scandinavia.

So idk.

I need brain injury help when it comes to mathematical intelligence, and stress resilience.

I'm already on vit d3 k2, magnesium, gotu kola and bacopa 24% for over half a year. Eating fish getting exercise.

I have a hard time getting a job more than 1 year ago since my tbi I was on disability but I can't lift over 5 pounds due to spine injury so can't do many jobs.

I had to take a break from high school but I dont think ill be able to even get my GED now I'm way too dumb. Idk what jobs I can get or what to do.

Not all psychiatrists are equal or get educated in quality schools so I'm bit scared of going to just any random one nor can I just throw money into a fire and travel to the best in the US repeatedly.

I hear lots of good stories about these peptide meds. But there are horror stories too.

I do not want things to get worse.

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u/HeadacheLife — 11 days ago

Mystery Product Guesses

Hi everyone, I’m sure that we all have our guesses for what the mystery product will be, and my guess is that it will be the long awaited CordyMAX. Why? ND has been teasing it for over a year now after finding out through their testing that their cordyceps has something special in it. MYASD has stated this in his Reddit comments in the past. Also, cordyceps is from the Himalayas region, which is mountainous, and Emiel had commented on those guessing Shilajit that they were right in the area it comes from, which is the Himalayas. Finally, what makes me almost certain that it will be CordyMAX is the fact that Emiel commented on the wrong guesses, such as Shilajit, Rhodiola, and Maca, but he did not comment on my comment or someone else’s comment about it potentially being CordyMAX.

What are your thoughts?

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u/Educational_Bird4557 — 13 days ago
▲ 2 r/NootropicsDepot+1 crossposts

What is the hype about L -theanine?

Okay, what’s everyone’s take on L-theanine? 👀

We keep seeing it everywhere lately, its so in trend rn, especially for focus + calmness, but does it actually make a difference?

For those who’ve tried it:

* Did you actually notice anything?
* What dosage did you take?
* With caffeine or on its own?
* Any side effects?
* Worth the hype or nah? 👀

Would love to hear the honest experiences ; good, bad, or “did literally nothing” 😂

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u/brew_akiro — 13 days ago

10 years of shift work and I'm running on fumes. What actually helps you?

I've been a firefighter for 10 years, and the rotating shifts mean I'm chronically short on sleep.
I catch up on my days off, but it's been piling up and my body just isn't what it used to be.
I want to stay sharp all day, and honestly the long-term health effects of sleep loss worry me too.

I've gone through a ton of coffee, but it barely does anything for me anymore, and I'm starting to notice side effects.

Lately I've been experimenting with different combos and have found a few things that seem to work.

Anyone else in the same boat? Is there a routine, product, or anything else you'd genuinely recommend?

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u/Economy-Growth-833 — 13 days ago

Infinifiber 6 month results...

started with one scoop a day, empty stomach...moved to two scoops a day after 4 weeks, but divided. one early morning on an empty stomach, one later in the day with a meal.

smelly farts, but otherwise well tolerated, no bloating, no reflux/heartburn as some fibers are known to do.

my diet is clean and was pretty much unchanged. noticeable bloodwork changes:

I/m older and my LDL has been static between 129-135 for years...it dropped to 121.

my hdl is always somewhere in the 60's, dropped to 51!

my total cholesterol dropped, but it was withing my 5 year range of 180 to 202

my triglycerides were in the 50's, normally 65-76 over the past 5 years or so, so a drop too, but mine are always good.

the results actually increased my cardiac risk because of the disproportionate drop in hdl to ldl and totals. Not sure what to make of this.

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u/MechanicHour1644 — 14 days ago

InfiniD and InfiniK

Psyched for both of these! My main genuine question is - what am I supposed to do with my 365 count bottles of D3+K2 when I swap to these??

Love the focus on nailing the basics - InfiniB is my favorite ND item by a mile (and there are so many good ones).

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u/baalzephon — 14 days ago

🎙️Coming Soon! In Search of Insight EP #61 | Epicomp | Dialing in Endurance and Recovery🎧

This month’s podcast episode is all about Epicomp, Nootropics Depot’s new fitness stack, made for building strength and endurance. This product release comes at a perfect moment for our Podcast Host Erika and Product Specialist Emiel, as they have recently gotten into long-distance walking and need all the endurance-boosting help they can get. Because when you just feel like walking, or running, you simply have to go the distance, no matter the cost.

Join us for the full podcast premiere on Tuesday October 6th at 10:00 AM MST. We’ll see you in the live chat!

u/NootropicsDepotGuru — 13 days ago