Psyched for both of these! My main genuine question is - what am I supposed to do with my 365 count bottles of D3+K2 when I swap to these??
Love the focus on nailing the basics - InfiniB is my favorite ND item by a mile (and there are so many good ones).
I have UARS/OSA with REM dominant events and use a BiPAP with relatively low pressures (12 IPAP and 5-6 EPAP + PS). I also am doing positional therapy (elevated sleep position + side sleeping) because events are much lower when not supine.
The BiPAP has been better than APAP because of the lower exhale pressures, but I'm getting mild to bad aerophagia when side sleeping even at these relatively low EPAP settings, preventing me from titrating the EPAP up further.
I also tend to mouth breath but use a nasal mask (Philips Dreamwear) with mouth tape, as I was intolerant to the full face mask.
Anyone have solutions generally for aerophagia like this, especially when it's positional?
I'm a 1gb customer but can't for the life of me get a hold of a customer service rep, or get the online tool to work (page just doesn't load) to tell me if and when my address in PHL will be eligible to upgrade to 2-5gb. Is there an easy way to lob in a request for a timeline on this? I know there are some official FCC channels to use that go to the legal team but that seems like overkill - except Verizon makes it impossible to figure any of this out otherwise.
I've had several workups of various angles of sleep disordered breathing from sleep medicine and ENT at a major university health system, but no one has really been able to pinpoint my issues thoroughly, and many of the doctors have been dismissive of things like UARS. I just saw a video from u/cpapfriend with Dr. Anil Rama (https://www.youtube.com/watch?v=wMniIjVpIpw), who seems to run a very comprehensive and detailed set of diagnostics - is there someone who does something similar on the East Coast who folks here recommend?
I got the Grip case and glow in the dark skin for the Pixel 11 Pro XL and the skin isn't properly designed for the case (with the two parts top and bottom to account for now narrow the gap is around the camera cutout). I spent 20 minutes trying to make it fit but it won't given the narrowness of the gap (note the obsidian skin, which comes in two pieces, works OK). What am I missing? Should I just cut the skin to make it work?
I'm planning to craft a Verdict of Justice for Rogneda. For the fourth slot, is it more damage to roll the additional crit damage mod, or another magic attack % mod (and at what amount is it better)?
Seems to me the flat magic attack % is probably better at sufficiently high magic attack but I'm hoping someone has done the math.
Anyone have a set of non-standard interventions for raising a low arousal threshold they could suggest? I'm aware of the usual medication interventions (DORAs, trazodone, mirtazapine, melatonin, etc) and have tried them all with limited success. Obviously treating sleep disordered breathing is a big one, which I'm doing, but I'm curious what else is out there that has helped people with LAT sleep through apnea events and other wakeners. LAT is a larger problem for me than desats since my O2 rarely drops below 95% even without breathing treatment but even minor disturbances cause sleep interruption.
Given the Chinese OSS models + OAI Sol are at parity-ish, especially considering cost, with Fable, has anyone noticed improvement in the AUP restrictions with Fable? I run a bunch of personal (and harmless) projects involving bio and genetics research using PubMed papers, and Fable is completely unusable, in addition to Opus and Sonnet throwing AUP violations on random papers (usually related to vaccines).
I think this, not cost, is what will sink Anthropic right now. I'm a Max 20x user and am going to start looking at other frontier models this week to migrate my projects over. Highest cost + total inability to use the model isn't a recipe for success, but I'd stick around if they stopped the unreasonable gating. I get the argument about the USG being all over them but the total blanket rejection of prompts related to biology and health is ridiculous and I'm sure not required by the USG.
Hot off the presses - https://pubmed.ncbi.nlm.nih.gov/42315445/ - DHA supplementation in older at-AD-risk ApoE4 adults moved CNS markers but had no impact on cognition. Pair this with https://pubmed.ncbi.nlm.nih.gov/42000571/ - the recent paper showing *decline* in cognitive scores for older adults supplementing DHA/EPA.
There are clearly a few threads to pull on here, including quality of supplement (ApoE4 folks should only be using krill oil or just eating fish), primary prevention window (recent research shows it's in your 40s), and brain metabolism of lipids, but certainly these go against the prevailing, simple, wisdom on supplementation for older adults.
I figure Emil or someone else may know this - why aren't there high dose Anserine supplements available in the US? They sell them in Japan for fatigue amelioration, but Anserine has been studied for neurodegeneration prevention and seems to be more bioavailable to the brain than L-Carnosine so I'm wondering why it's just totally absent in the US. In contrast, I suppose, we have a lot of beta-alanine supplements available but these are mostly for workouts and brain delivery studies aren't available.
OK weird request y'all. We are hosting a small dinner party and need to outsource the cooking. We want the food to be GOOD (let's say Suraya quality) but every decent restaurant we call won't do takeout at dinnertime. We're willing to put the order in early and drive wherever we need to pick it up. Any recommendations?
I just did whole genome sequencing with Nucleus for me and a few family members. Solid A/A- experience - the whole process took a few weeks (fewer than expected) and we received high quality files that I was able to run through a local genomics pipeline to get detailed analysis for the family.
The - here is for the Nucleus probability reports and analyses, which are OK, but have the detailed information hidden and are presented in too "risk forward" of a way. They also missed a few things that my local genomics pipeline caught.
In any case, for anyone looking to do WGS for their family, as a first-timer who is technical, I thought this was a very solid offering.