The study tested microtesla magnetic therapy (MMT) as a treatment for cognitive problems in Long COVID.

Design: small randomized, sham-controlled, triple-blind pilot trial; 30 participants completed it (20 MMT, 10 sham). 15 minutes, twice weekly for 4 weeks, using a low-amplitude 27.12 MHz magnetic field.

Possible benefits: the MMT group showed larger improvements by week 8 in:

• working memory
• verbal learning/memory
• processing speed
• anxiety
• emotional well-being

But: the cognitive and most quality-of-life findings did not survive correction for multiple comparisons, and the key mixed-effects analyses generally did not show significant treatment × time interactions.

Bottom line: MMT looks feasible and apparently safe, with some intriguing signals of efficacy, but this study does not establish that MMT works for Long COVID cognitive impairment.

Personal opinion: I dont know what they hope to achieve with 15 minutes, twice weekly. Does not sound like much of anything.

My nervoussystem feels way worse for two weeks now slowly getting worse with no clear trigger. It is my first time experiencing a october slide. But i dont understand why. My day to day has not changed at all and temperatures did not drop that much either.

Last year I had the same issue but it was my first covid year so i was just pacing worse. But this year it really seems to just be from the change of seasons.

Is there anything to make this period easier?

I have too little understanding about this topic but this is what I made sense of:

The SARS-CoV-2 Spike protein can activate human brain immune cells(microglia). The microglia promote inflammation with the microRNA "let-7a-5p" it produces. This microRNA both cascades inflammation AND weakens an important inflammation brake called SHIP-1.

This was mostly done in a lab with human grown cells.

Ich stecke wegen Krankheit dauerhaft zuhause und suche daher Menschen, die einfach Lust auf schreiben an sich haben. Ich bin an Reisen, Philosophie, Geschichte interessiert. Sonst mag ich Anime, Videospiele. Ich weiß das ist nicht genug um eine Konversation zu brechen. Ich bin interessiert über einfach alles zu reden. Meine Idee zum Schreiben: Wie sieht dein Traumurlaub aus?

LG

I often see people with elevated HR issues. I have these too but I know my triggers and am otherwise in the normal range. But when I overdid it, on the next day I have moments where my heart cant keep up somehow but I feel okayish?

Woke up today with pain in the chest and fatigue in precisely one spot: the heart muscle.
Now I showered sitting and my HR went to 55 for 10 minutes afterwards. And I felt okay. But that is not normal even for a healthy person no? I went around in my apartment, got dressed and it barely changed.

I was wondering if anyone else has this? I did not feel nauseous.

https://www.sciencedirect.com/science/article/pii/S2213158226001002

The study investigated whether the early physical fatigability experienced by people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is caused primarily by problems in the brain (central mechanisms) or the muscles (peripheral mechanisms).

Researchers recruited:

• 15 people with ME/CFS
• 19 age- and sex-matched healthy volunteers

Participants performed repeated hand-grip contractions at 50% of their maximum force while researchers simultaneously measured:

• Grip force
• Muscle activity (EMG)
• Brain electrical activity (EEG)
• Brain activity (functional MRI)
• Brain–muscle communication (corticomuscular coherence, CMC)

Fatigue onset was determined individually based on when grip-force performance began to decline.

Key findings

1. ME/CFS patients fatigued much earlier

• Maximum grip strength was similar between groups.
• However, people with ME/CFS reached fatigue much sooner and their grip force declined faster during the task.

2. Healthy participants adapted their nervous system to delay fatigue

As healthy volunteers approached fatigue:

• Brain activity steadily increased (EEG and fMRI)
• Muscle electrical activity shifted in the expected way for developing fatigue
• Brain–muscle communication increased

These adaptations appeared to help maintain performance longer.

3. ME/CFS participants showed little or no adaptation

In contrast, ME/CFS participants showed:

• Minimal changes in brain activation
• Minimal changes in muscle electrical patterns
• Little increase in brain–muscle communication

Their nervous system remained relatively "flat" throughout the task despite worsening performance.

Interpretation

The authors conclude that the earlier onset of fatigability in ME/CFS is primarily associated with impaired central nervous system responses rather than reduced muscle strength.

Their interpretation is that:

• The muscles themselves appear capable of generating normal maximal force.
• The brain fails to progressively increase its drive to the muscles during sustained effort.
• This reduced central activation likely contributes to earlier performance failure.

The authors emphasize several limitations:

• The study included only 15 ME/CFS patients, making it relatively small.
• The findings should therefore be interpreted cautiously until replicated.
• The results show an association, but the study cannot definitively prove the exact biological cause of the impaired brain response.
• Other factors such as pain, perceived effort, or fear of triggering post-exertional malaise may also contribute.

This multimodal neuroimaging study provides evidence that objective physical fatigability in ME/CFS is linked more strongly to altered brain function than to impaired muscle function. Compared with healthy individuals, people with ME/CFS failed to recruit additional brain activity during sustained effort, which was associated with earlier fatigue despite normal initial strength. The authors suggest these findings support a central (brain-based) origin of fatigability and may help guide future research into treatments targeting central nervous system mechanisms.

Researchers wanted to find out if low selenium levels and antibodies against a selenium transport protein (SELENOP) are linked to long-lasting fatigue after COVID-19 (Long COVID).

Method:

• 750 adults in Germany who had a confirmed COVID-19 infection.
• Participants were examined about 22 months after infection.
• Blood samples were tested for:
  • Selenium levels
  • SELENOP (a protein that carries selenium in the body)
  • Antibodies against SELENOP (SELENOP-autoantibodies)
• They also asked participants whether they still had fatigue and how severe it was.

Findings:

• About 23% of participants still had persistent fatigue.
• Many people had low selenium or low SELENOP.
• Only a small number had SELENOP antibodies.
• Low selenium alone was not strongly linked to fatigue.
• Low SELENOP alone was not strongly linked to fatigue.
• SELENOP antibodies alone were not strongly linked to fatigue.
• However, people who had a combination were about twice as likely to have long-lasting fatigue after COVID-19.
  • low selenium + SELENOP antibodies, or
  • low SELENOP + SELENOP antibodies

The researchers think that:

• Inflammation caused by Covid-19 can lower selenium levels in the body.
• Some people develop antibodies that block SELENOP, making it harder to move selenium to important organs like the brain and thyroid.
• This may reduce energy production and contribute to long-term fatigue.

The study suggests that a small group of people with Long COVID may experience persistent fatigue because they have both low selenium and antibodies that interfere with selenium transport. These people had about two times the risk of long-lasting fatigue compared with people who did not have both problems.

I noticed my ears finally stopped having a constant sensitivity for the last 3 weeks. I could stop wearing the damn industrial grade noise-protection headphones for some minutes a day. watch some videos with sound. listen to some music. Even short excanges with my family.

Now today my mom visits and just cant control her fucking voice disbite warning her everytime she comes by. She manages to actually talk quiet for some time only to go full loudness right when she hugs me directly into my ear. Ear problems are back 30 minutes after

Now another 2 weeks of noise sensitivity,,,
I want to punch her honestly.

I notice that i have a shorter fuze when dealing with people.

I am unsure where it is coming from. Covid? Aging? The state of the world? From living in a world where society does care so little for this issue? The experience of severe longcovid itself and therefore losing sympathy for the ignorance and issues of normal people?

Researchers investigated whether a sleeping virus called HHV-6B becomes active again after COVID-19 infection and contributes to these symptoms.

What is HHV-6B?

• HHV-6B is a very common herpes virus.
• Most people catch it in childhood.
• After infection, it stays in the body for life in an inactive (latent) state.
• Sometimes stress or illness can reactivate it.

The researchers looked for a protein called SITH-1, which is made when HHV-6B becomes active. They measured antibodies against SITH-1 in blood.

They studied 156 people with Long COVID.

They found that:

• About 63% had antibodies showing HHV-6B had become active again.
• These patients had more severe fatigue and depression than patients without these antibodies.

In mice, the researchers found that SITH-1:

• Reduced production of acetylcholine, an important brain chemical.
• Caused depression-like behavior.
• Reduced activity of brain cells involved in memory and mood.

This suggests that reactivated HHV-6B may reduce acetylcholine, leading to some Long COVID symptoms.

Donepezil is a medicine commonly used to treat Alzheimer's disease. It works by increasing acetylcholine levels in the brain. Among Long COVID patients who had evidence of HHV-6B reactivation:

• Donepezil reduced fatigue.
• Donepezil improved depression symptoms.
• Patients without evidence of HHV-6B reactivation did not appear to benefit as much.

The study suggests that:

• Long COVID is not the same in everyone.
• Around two-thirds of patients in this study may have symptoms partly caused by reactivation of HHV-6B.
• A blood test for SITH-1 antibodies might help identify patients who are more likely to respond to donepezil.

I am moderate but my noisesensitivity is severe. It is so wierd to me how I can sit for an hour and play a videogame but cant handle 3 minutes without noise protection even within my own 4 walls because the birds outside somehow are to loud for me to handle.

There are millions of people in a personal hell and millions more with weakened imunesystems, heart issues, lung issues, sleep issues. You name it.

All because of covid. And the numbers are rising.

And compared to this damage the effort, attention, ressources given to this problem are so absurdly miniscule that i am in utter desbelief. It feels like someone is making a bad joke.

I am honestly just out of words.

Heat robs of even more energy. Try to stay out of the sun. Try to cool your room down. Try to keep cool.

For sleeep you can get a smooth silk duvet cover. Plus a extra heat isolation overlay for your matress.

I recommend having a bucket with water near your bed to hang one foot in to cool down fast. This can cool your entire body down fast.

More ideas are appreciated.

Main takeaways:

• The researchers found that pediatric long COVID is not one uniform illness. Instead, there appear to be several biological “subgroups” with different immune and metabolic patterns.
• Symptoms often stayed severe for years, especially fatigue and reduced daily functioning, with little sign of spontaneous recovery across the cohort.
• Standard cardiopulmonary tests were mostly normal, suggesting symptoms are not explained by obvious heart/lung damage.
• The immune system patterns changed over time:
  • within the first year, antiviral immune signals were more prominent;
  • later, more chronic innate inflammatory and Th2-skewed immune activity persisted.
• The study did not find strong evidence for classic autoimmune disease markers overall, though one antibody pattern (anti-DFS70) helped distinguish subgroups.
• Blood metabolite analysis identified differences tied to:
  • disease duration,
  • Epstein–Barr virus exposure,
  • immune subtype.
• Higher levels of neurofilament light chain (NfL), a marker associated with nerve-cell injury/stress, correlated with worse functional impairment.
• In children without prior EBV exposure, higher thiamine (vitamin B1), IL-12p40, and basophils were associated with milder disease.

Bottom line:
The paper argues that pediatric long COVID likely consists of multiple biologically distinct conditions rather than a single syndrome. The authors suggest future diagnosis and treatment may need biomarker-based personalization instead of one-size-fits-all approaches. So not that much new but the last part seems interesting.

Ich sehe so viele Posts mittlerweile, bei denen ich mich frage ob das nicht KI generierter Content ist. Manchmal ist es offensichtlich, manchmal weisen einen andere Nutzer drauf hin.

Aber im großen Ganzen habe ich das Gefühl es wird immer mehr. Und den Kommentaren kann man auch teilweise nicht mehr trauen.

Das ist für mich ein Grund die Webseite nicht mehr zu nutzen. Warum soll ich mir Fake-Posts anschauen und drunter die Fake-Kommentare lesen.

Ich nutze Reddit wie viele als Unterhaltungs-; und Nachrichtenquelle. Aber ich fand es auch immer gut ein bisschen ein Gefühl für andere Meinungen bei aktuellen Themen zu bekommen. Reddit ist für mich noch einer der "gepflegteren" Social Media Seiten aber das scheint sich gerade irgendwie aufzulösen.

TL;DR: 1 Year after infection from almost severe to moderate bordering on mild. LDA 0,5 mg and LDN 1,5 mg + Magnesium help my Sensitivitys/ Fatigue and SFN.

M26, Vaccined multiple Infections causing weak immunesystem and food intolerances with another Covid-Infection causing Post Viral Fatigue in May 2025.

• PEM
• small fiber neuropathy
• POTS
• leaky gut syndrome
• weak immune system
• heat dysautonomia (extreme body temperature changes based on daytime)
• food intolerances
• extreme sensitivity to light/sound/touch/smell/human presence

- no histamine-intolerance
- no MCAS
- no brainfog
- minor insomnia

what i take

• low dose naltrexon (LDN) 1,5mg -> 0,5mg 1hour before lunch and 1mg before bedtime
• low dose aripiprazole (LDA) 1mg before bedtime
• prebiotics to restore the gut (probiotics gave to heavy sideeffects so I had to give them up)
• melatonin
• magnesium

After 1 year

• baseline up for PEM (from bordering on severe to comfortably moderate)
• small fiber neuropathy small improvement
• POTS unchanged
• leaky gut syndrome small improvement
• immune system unchanged
• heat dysautonomia major improvement
• food intolerance small improvement
• Light sensitivity way down (screentime from 10 min a day to >3 hours). Still in a dark room
• Touch sensitivity & human presence issues gone

Storytime:

Like many, I developed health issues from coid but didnt make the connection. In 2024 I got sick every 5 weeks even in summer. New food Intolerances etc.. While traveling I got reinfected and had multiple PEMs in a foreign Country... I was hospitalized once and went to the ER twice. After 3 Weeks isolated in a hotel I managed to fly back to germany and instantly felt way better from the better climate, air and the psychological relief to be home.

Then I pushed it to soon again because of family troubles. And i crashed HARD.
Went from mild being able to cycle to almost bedbound within 2 weeks of rolling PEM. I only stabilized by giving up everything i could at the time. I spend days not looking at my phone, not doing more than walking to the toilet once a day.

I am very privileged and lucky to have basically every family member, doctor and friend believe me. Also This sub gave me enough understanding about what was going on with me. The hospital gave me a positive covid test. I also had a antibody test and a mitochondrial function test 1 month later.

Still i worsened slowly. I tested gut health, deficiencies and food intolerances. Turns out Covid wrecked my gut flora and therefore my body became unable to properly absorb all nutrients from food. Also I got leaky gut syndrome causing food intolerances. So I am also taking Prebiotics. I dont feel a big difference but I will keep taking them.

I started improving fatigue-wise by pacing and time. I feel guilty because there is nothing else really. I believe I only have post viral fatigue not cfs. Still the sfn and sensitivitys stayed/stay. Here is where LDN and LDA made a huge difference for me in the last 2 months (taking both since 5 months).

I still am a looong way from being healthy again and I know a since reinfection will ruin my progress.

Still I want to share my story for those that just got this illness or those not sure about LDN / LDA.

Regarding LDN: I cant hanlde the 1,5 mg in one go so I split it up to 0,5 mg before lunch (1hour) and 1 mg before bedtime.