u/Holiday_Acadia_9524

Massive doses of Famotidine (Pepcid)?

I take 140 mg spread throughout the day. I’ve read that for Zollinger-Ellison syndrome the max dose is 120 mg every 6 hours, so I’m still well below that. I’m bed bound from a CSF leak and have to lay completely flat all day for the past 6 years, which is why I have GERD. PPI’s all caused awful cognitive side effects/headaches/ear-ringing. I know there are serious heart risks with high doses of Pepcid. Just wondering if anyone else is on super high doses like this, or how dangerous it actually is? My doctor didn’t seem too concerned, but it still makes me nervous, and I would like to not be nervous.

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u/Holiday_Acadia_9524 — 1 day ago

▲ 0 r/cgrpMigraine

Duel CGRP therapy? Has anyone tried it?

I’m on every class of preventative and still chronic (caused by EDS and an intractable CSF leak). Dr. Google AI recently suggested trying two CGRP preventatives at once. Has anyone tried this? Any chance of actually getting U.S. insurance to cover it?

From Google A.I.:

"Dual CGRP" Therapy (Adding Qulipta)

This is currently a leading strategy for refractory migraine. You are already on Aimovig (a monoclonal antibody), but some specialists now prescribe a Gepant (like Qulipta) alongside it. [1]

Why it fits you: Aimovig blocks the CGRP receptor, while Qulipta blocks the CGRP ligand (the protein itself). Attacking the pathway from both sides can sometimes break through where one drug alone cannot.
Safety: Recent studies suggest combining these classes is safe, though insurance approval can be the main hurdle (your doctor may need to argue "medical necessity" due to failure of other classes). [1, 2]

u/Holiday_Acadia_9524 — 3 months ago