r/cgrpMigraine

I’m still using tiny pieces of pills from an ancient prescription. No one will write a script for more so that’s annoying. I use Amerge and Imitrex plus flexeril, excederin, motrin, benedryl, magnesium….just want to put it out there because its bs that the medical community won’t admit benzodiazepines can be a saving grace for migraine. Thank you for coming to my TED talk.

As the title sais, I've been on atogepants for three months now. They definitely brough the severity of my attacks down (from maybe an average 8/10 to a 3/10) but so far they haven't touched frequency. I still get over ten migraine days a month, they just aren't as bad as before. So question for people who've taken qulipta: Has the effectiveness further improved even after the three month mark, or is this as effective as they're going to be for me? I know everyone reacts differently to migraine meds ofc, but I'd like to hear about experiences others had ^^

Just been diagnosed with a mild acute diverticulitis at hospital and I’m wondering if it could have anything to do with CGRP meds?
I was on Ajovy for 8 months and then had one round of Vyepti (horrible 😭) and now only about 10 days into Ajovy again.
I’m wondering if there could be a link? Either that or steroids, which I’ve had 3 rounds of in 4 months.

Hello
Been on qulipta for almost a year 30mg daily. Stopped cold turkey 9 days ago and just started feeling super moody, anxious, my vestibular migraine ear and neck symptoms coming back on and off, super moody and irritable, cry spells hot flashes are back (I am 49 woman and post menopause 2 years now) nervous system out of wack!
Anyone else feel this and how long did this crap last? I know drs say no withdrawals but I don’t Venice anything they say because every time they said can stop cold turkey (like HRT I took for two months and caused these damn vestibular migraines in the first place! Plus years of anxiety from trauma and PTSD), I’ve had terrible symptoms stopping cold turkey I’m very sensitive plus I have severe anxiety which I also take nortriptyline 10mg daily for both vestibular migraines and anxiety . I do do Botox for migraines thank God after 9 months started helping the pain that’s why I am trying to come off quilts but it for sure messes with your brain chemicals and moods which I know my migraine symptoms also cause my mood disorders and vice versa.

Thank you 🙏🏼

I was on Ajovy for 3 months when I started getting tingling in my left side of face that progressed to left arm then left leg. I switched to Quilipta a month and a half ago. The tingling is still there but now my left leg is also having a burning sensation too. I am concerned I have nerve damage. And while I don’t know what is happening or if it’s related to ajovy or Quilipta, I am suspicious of them. I have an appointment with general neurology for nerve testing in October. Too far out.
Has anyone had any similar issues with tingling aching or burning sensations after being on a cgrp medication.

All my imaging and lab work has been normal, including MRI brain and spine.

I’ve being on it for 3 months and some of my side effects have being constipation but diarrhoea also, stomach issues and this REALLY PAINFUL WRIST PAIN I HATE

Do any of you guys who is on it have it too?

Im on my third month of ajovy (my third shot was last Friday) and it's going fine. However, since I'm only on my third month it hasn't really "kicked in" yet in terms of effectiveness. My doctor OK'd me to continue taking my ubrelvy for break through migraines, which I've done many times now without issue.

However, my ubrelvy script was due for a new pre-auth recently and my insurance has decided to be uncooperative about covering it. My doctor is going through the appeal process, but we won't know the final verdict for awhile. Since my future access to ubrelvy is currently unknown, I've tried taking some of my rizatriptan stash with my last two migraines - I HAAAAAAAAATE rizatriptan, but they weren't bad migraines so I thought I'd try to deal and save my ubrelvy for bigger migraines on more important days.

However, both times I became extremely nauseous and threw up??

I've never thrown up on rizatriptan prior to starting ajovy and have never thrown up on ajovy (or when taking ajovy with ubrelvy) so this is definitely new...

Has anyone else found that ajovy and triptans dont mix or is this just a me issue?

muy buenas a tod@s. simplemente es comentar mis sentimientos.... frustacion. impotencia. rabia. desesperacion. agradecimiento y amor.

soy hombre de 53 años con migrañas desde mi nacimiento.. asi que he probado todo a nivel medico y terapeutico.. y más alternativas

toda mi vida lo he llevado lo mejor posible y poniendo mi mejor cara de cara al publico aunque por dentro deseas morirte...

pero estas 2 ultimos años estan siendo muy criticos... llevo 15 meses de baja laboral..

en enero 2025 empece tratamiento con Ajovy tras probar toda clases de medicamentos que no me funcionaban o los efectos secundarios me remataban.

Ajovy empezó como una esperanza pues el primer mes parecia que la frecuencia e intensidad de mis ataques bajaban... pero a partir del segundo mes a finales volvian de nuevo todas mis crisis mas efectos secundarios como insomnio debilidad extrema. dolores articulares. lagunas mentales. etc.....intente aguantar hasta el tercer mes y visita adelantada al neurologo.. el cual me retira tratamiento y me comenta que estos efectos secundarios no son logicos por Ajovy.. asi que aquí mi Frustación. porque tu propio neurologo duda de lo que dices y de aqui la rabia e impotencia.

tras unos 3 meses de descando CGRP para que mi cuerpo recicle me proponen Emgality. primera dosis doble cuando aun yo seguia con sintomas de los efectos secundarios Ajovy... asi que Emgality tras 2 semanas de la doble dosis mi cuerpo empezo a volver a incrementar mis efectos secundarios.. asi que visita al neurologo de nuevo y me retiran Emgality y siguen diciendo que los sintomas que temgo no deberian ser de los CGRP volvemos a la impotencia rabia frilustacion..porque le explicaba al neurologo que despues de 3 meses retirada de Ajovy empezaba a notar mejoria en algunos sintomas de los efectos secundarios y al inyectarme Emgality han vuelto de nuevo.. y que me digan que no es del CGRP es Frustrante....

indico que desde el princioio tratamientos CGRP combino con triptyzol sertralina..

junto mis medicamentos de rescate Maxalt y los AINES...

Tras varios meses sin los CGRP en Marzo 2026 empezamos con Aquipta 60mg dosis diaria por las noches.. tras casi 3 meses de tratamiento mis migrañas pasan a se una media de 12 al mes nivel alto y resto dias niveles medios y bajos pero como siempre migrañas diarias y resacas... y vuelven los dolores articulares cansancio fatiga. perdida de memoria etc. etc. entre medio del tratamiento visita a la psiquiatra la cual me receta Mirtazapina 15mg para mi insomnio aun siguiendo con la sertralina y triptizol.. tras unos de del Mirtazapina me ponia mas ansioso y nervioso.. se lo comunico a mi psiquiatra y me dice que mi cuerpo se tiene que acostumbrar y me receta lorazepan 1 cada noche.. asi que mi vida ya no existe pues si antes era un zombi ahora no llego ni a eso...

ahora tras visita neurologo y sin respuesta efectiva de Aquipta me la retira...y de nueco el neurologo dice que mis sintomas no cree que sea del CGRP.. pero que mas quiere 3 CGRP me ha metido y los efectos secundarios los mismos.. asi que mucha rabia e ira... impotencia...

agradecimiento y amor a tod mi familia y amigos que me apoyan y en eapecial mi mujer que es el mayor tesoro que existe...

asi que hasta aqui os puedo contar ya que al retirarme Aquipta mis migrañas llevo 8 dias seguido al maximo nivel y tomandome de todo para intentar sobrevivir y yendo a urgencias para ver si pueden hacer algo y que me adelanten visita neurologo porque me la han puesto en octubre.... asi que seguimos en espera a ver cual es el siguiente CGRP..

SIENTO LA PARRAFADA... pero lo necesitaba y si alguien esta igual que me comente.

os deseo lo mejor ❤️❤️

Hi I’m 20F I get migraines but I’m also a liver transplant patient and I’ve been listed for liver transplant for 5 months. I was taking Emgality but the injection gave me panic attacks so I started to take Qulipta. I’ve been taking Qulipta for a few days at bedtime and overall it’s been pretty good. But I’ve started to get some stomach pain which I think is probably constipation. I also had a very weird experience sleeping last night. It’s like I kept waking up and closing my eyes constantly. I don’t remember it exactly but that’s what I can remember. The migraines have to get figured out and I don’t know what to do. I don’t want to suffer from them so that’s why I take something for them. I’m scared that taking all migraine medicine away will make things even worse. I love a pretty normal life, pretty busy, I have school and work and responsibilities that I need to function through

Guys I am desperate. Qulipta is the only med that prevents my chronic *daily* migraines. I just started on 10mg down from 30mg because my anxiety and irritability on 30mg was unbearable.

The 10mg is equally effective at preventing my migraines but that also comes with the same side effects in full force 🥺

I need this to work. When not on Qulipta I’m taking so many triptans my Neuro is worried I’m going to have a heart attack. If I don’t take the triptans I am essentially disabled and in emerg unable to work or look after my kids…

Has anyone had similar side effects and they’ve gone away after time? Or successfully treated them with another med?

Adding another med is the last thing I want to do but if it means I stay migraine free then so be it.

on aimovig for about a year now life changing way fewer migraines. i can function like a normal person. but the dry mouth side effect is no joke. i wake up feeling like i swallowed a bag of sand. my dentist said my enamel is eroding and i have more cavities than i've ever had. i asked my neuro about it and she just said drink more water. like thanks i hadn't thought of that. the dentist wants to do a bunch of fillings and a prescription toothpaste that costs like 40 a tube i can't win. either i have migraines or my teeth fall out.

my friend on the same meds said she found a dentist through Smile Partners USA who actually understood the connection between cgrp meds and dry mouth. said they gave her practical advice instead of just guilt trips.

anyone else dealing with this? have you found anything that helps with the dry mouth that's not just drink more water? also did anyone switch meds because of this?

Ugh. This has started happening to me. This is the third time it’s happened and it makes me so anxious because what should I even do?

My neuro told me the first time it happened that it’s okay to take a ubrelvy as long as it isn’t a frequency occurrence. It makes me so nervous though… should I not take anything since the Nurtec is “still in my system?”

Any advice appreciated.

Question for you guys, I plan on getting a greater area occipital nerve block (in the crevice on neck) 5 days before family vacation. I’m wondering if I should wait until I return. I’d love some relief for my vacation but I’m worried it could worsen my symptoms. I have atypical Trigeminal pain from chronic migraine…
From research on here it sounds like there’s little success and some got some weird effects… would love to hear your experiences.

I'm prescribed a monthly dose of ajovy. It's fine at room temp for seven days so when I get home I always just put it on the counter and don't bother with refrigerating it. I did the same thing a few days ago and did not realize they gave me three injectors. When I opened the box a few hours later and saw three I had a full breakdown because it was too late to refrigerate.

I asked my nuerologist if I could just take three and have it last three months and she said "that's not how that works". She said my options are to ask the pharmacy or the ajovy people because my insurance won't cover replacements for the next two months. Apparently I was supposed to keep the large box in the fridge and take an injector from it each month??? Help.

Since it plays a role in immune system... I noticed I'm developing a wart after 22 years without experiencing any. Honestly wondering if it could be related to taking the meds

I am having a horrible time after taking my first injection 3 weeks ago. First, my severe dizziness came back. I have worked over a whole year to get better from dizziness. Since the injection, my bedtime has shifted and I have noticed I was having a lot of anxiety. I also had heart palpitations and now I am not falling asleep until 4am. My body jolts me awake every time I am drifting into sleep. I have read up on the sub and I saw people felt a lot more anxiety on this injection as well. I am not taking the next injection but it is still in my system. I’m tired of not sleeping. Anyone else has experienced this recently and how long does it take to get better?

I am on day 90ish of my cycle and have not had a period since injecting Ajovy for the first time.

Wondering if this happened to others and if it went back to normal just with time? I don’t wish to suspend the medication but want to have my period to avoid uterine fibroids and other concerns.