u/Honest-Injury-3632

My mom has Stage IIIB adenosquamous NSCLC in the right lung, with N2 mediastinal lymph nodes.

Her mutations are KRAS G12C and TP53, with PD-L1 30%.

She completed 3 cycles of carboplatin + gemcitabine. The main lung tumor decreased by around 5-10 %, but the lymph nodes didn't improve much.

Now she has one brain metastasis around 1 cm and is currently completing 5 sessions of brain radiation.

What I'm confused about is what usually comes next.

Has anyone had a similar situation? Did you have lung surgery after treating a single brain metastasis? Did you use sotorasib (Lumakras) or another targeted/systemic treatment?

Would really appreciate hearing from anyone who has been through something similar.

Thank you.

Mom has Stage IIIB adenosquamous lung cancer, KRAS G12C, and now one ~1 cm brain metastasis.

She completed carboplatin + gemcitabine. The main lung tumor shrunk about 5-10 %, but the lymph nodes didn't change much. She's currently getting 5 sessions of brain radiation.

Has anyone been through something similar? What treatment did you have after brain radiation? Did anyone have surgery/lobectomy or use Lumakras (sotorasib)?

Just looking for experiences and advice.

Thank you

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