



ANA ELISA Positive, but ANA IFA negative?
Hi everyone!
I was encouraged to post on this subreddit, hopefully someone can help. I (31 F) finally saw my PCP in April after years of symptoms. Bloodwork returned with a positive ANA and positive for Anti-SSA among other thyroid related issues; I was told I had Sjogrens and was referred to a lackluster rheumatologist.
Finally saw this rheumatologist and he had more extensive panels done through Avise. My results came back but they said they would "go over diagnoses when I see him next month."
I decided to go pick up my results myself because I have an endocrinologist appointment next week, and my results have me confused.
My ANA IgG (ELISA) test was a strong positive, but my ANA by HE-p2 (IFA) was negative. Under the Sjogrens category, my Anti-SSA/Ro52 IgG (ELFA) were also positive. My anti-thyroglobulin was "equivocal" which is interesting, I previously had an elevated TSH and have been on Synthroid since April.
Previous labs from April indicated high morning cortisol and high ACTH; no one has discussed this with me but I do not have any symptoms of Cushing's disease.
I would be sincerely grateful for any help or direction anyone can provide.
Edit to add: Only other diagnosis is POTS (cardiologist diagnosed); 2 medical professionals have expressed thoughts I have hEDS - I brought this up to my rheumatologist who didn't think I had it because my "elbow wasn't hypermobile" - but no official diagnosis.
Also not seeking a firm diagnosis! I know there's much more to it all then bloodwork, I'm just trying to understand these labs. Sjögrens very much seemed to fit but these conflicting ANA results have confused me.