r/haematology

I suspect a possible GI bleed

Hello, I'm a 26 yr old F who got put on blood thinners back in March due to two small blood clots in each side of my lower lungs. Those have gone away but I still have to continue my blood thinners (eliquis) most likely for the rest of my life because of a blood clotting disorder. The one they believe I have is prothrombin gene mutation F2. I haven't seen a rheumatologist yet but I have seen an oncologist once last month. I also have a suspected autoimmune disease called Mixed connective tissue disease (MCTD).

Fast forward to maybe a week ago I was having some constipation issues and I do take iron pills every other day but noticed some blood in my stool and told my primary doctor about it. I never went to get checked out for it but have been noticing lower blood pressures and a bit of a faster heartbeat here and there. My doctor got concerned and ran a blood test of some sort for my hemoglobin and that came back fine. I went to the hospital on the 5th for more blood in my stool and they only checked my blood levels and hemoglobin, no sort of ct scan or anything. The doctor that evaluated me told me that I'm to young to have a GI bleed and to go home. I've been experiencing abdominal pain lately.. the blood has gone away but I'm still concerned about a possible GI bleed weather it's a slow one or not. I'm on blood thinners and apparently GI bleeds are a serious thing?

Nobody is taking it seriously though and the next time I go to see my primary doctor is on the 13th. I don't want to just sit around and wait for more possible symptoms, I have a newborn that I take care of daily. I can't afford to leave this earth. The reason for not running a scan is because I've had 14 scans in the last 4 months. 7 on my head, 3 on my abdomen without iodine and 1 with contrast and 3 on my chest. What can I do to get them to take me seriously? I also have to wait on a referral for a GI doctor which who knows how long that will actually take.

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u/SiIverSkies — 10 hours ago

Went for an annual physical. 30m. Live at 4600ft, work at 7000.

I started talking Vitamin D, K2, and a multivitamin with large amounts of B12 in it in the month before my physical.

Also started both more frequent and higher altitude exercise in the last month or so with some of the higher altitude hiking becoming available.

I’ve stopped all the vitamins since, also was a bit dehydrated before the blood draw.

My PCP scheduled another test. Guessing it’s nothing but what does the internet think?

u/Agreeable_Estate1973 — 7 hours ago

Where did my blood go?

56f, 165cm, 60 kg, non smoker, usually no meds, now lots of pain killers.

Last week Monday I had a THR with general anesthesia. When I woke up I felt really shitty, which continued the next day. Doctors did some tests and found my hemoglobin dropped from 12.8 before the surgery to 7.4 after. They gave me an EC transfusion and slowly I was getting better. Surgeon was not there this day. When he came the next day he said I did not lose much blood during the surgery and there must be something else. This is a very experienced and respected surgeon.

They took stool und urine samples, stool was negative, urine positive but not enough to explain this and they wrote it down as "not explainable blood loss".

Now I am home and wonder what could have happened there.

Any ideas?

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u/onirak — 6 hours ago

Being referred to hematology

Hello,

I'm a female, 50 years old, started menopause 11/2021. I've never been on any HRT's. I'm 5'9" and 220lbs. I have never smoked or used drugs, and I haven't consumed alcohol since I was 25(don't like it). I'm currently taking Olmesartan 20mg/day(prescribed) for high BP. I also take Vitamin D and K2 daily(not prescribed). I had my labs done today and my doctor has referred me to hematology. I seem to always be slightly elevated with a few labs. I would appreciate an opinion as to what is so concerning. I'm also B- if that matters for blood type.

Current labs below. Pictures will show the data for previous draws back to 2016.

WBC 10.6

RBC 5.7

HGB 16.4

HCT 50.4

MCV 88.4

MCH 28.8

MCHC 32.5

RDW 12.3

PLATELETS 376

MPV 9.9

Thank you for any feedback.

u/Jesus-is-my-Lord- — 7 hours ago
▲ 17 r/haematology+1 crossposts

Not feeling heard by my PCP

These were my blood draw results and I’ve had to reach out to my PCPs office twice about the results. I was told that everything was fine, my ferritin is on the lower end but my PCP said the analogy that my “salt in the pan was fine (my iron in my blood) but my reserves were a little low (supply of salt in the pantry)” and that I only have 1/4 markers for iron deficiency. However, I showed my results to my partner’s mother who is a nurse and she was saying I should be on iron supplements.

I just don’t know what to think anymore. Should I try to go to a different physician? Or is my PCP correct? I’m just really tired of being exhausted and dizzy all the tjme.

u/tarperha — 21 hours ago

Positive ANA...but also negative?

I (31 F) finally saw my PCP in April after years of symptoms. Bloodwork returned with a positive ANA and positive for Anti-SSA among other thyroid related issues; I was told I had Sjogrens and was referred to a lackluster rheumatologist.

Finally saw this rheumatologist and he had more extensive panels done on me through Avise. My results came back but they said they would "go over diagnoses when I see him next month."

I decided to go pick up my results myself because I have an endocrinologist appointment next week, and my results have me confused.

Has anyone else experienced this before?

My ANA IgG (ELISA) test was a strong positive, but my ANA by HE-p2 (IFA) was negative... I thought both are usually positive. Under the Sjogrens category, my Anti-SSA/Ro52 IgG (ELFA) were also positive. My anti-thyroglobulin was "equivocal" which is probably due to the Synthroid I'm on.

I know no one is a doctor here, I'm still seeking medical help! I just am trying to understand if anyone else has had this.

Previous bloodwork indicated HIGH ACTH and HIGH morning coritsol as well as HIGH TSH; all else normal.

▲ 9 r/haematology+1 crossposts

Mystery Illness Ruining My Life- mildly elevated wbc 3 mo

30F — sick for 3 months, persistent high WBC. Please help :(

I’ve felt unwell for about 3 months.

Main symptoms:
Daily fatigue
Low appetite and weight loss - 160 last year this time, 149 when this illness started, 133 now
Waking up hot/sweaty, sometimes with low-grade temps
Headaches
Weird sore/restless feeling in my legs- this might be the worst symptom. I am so restless that I can barely function. I can’t even focus on watching TV. I just want to crawl out of my body it is sooo awful

My bloodwork has repeatedly shown:
WBC ranging from 11.3–15.0- fluctuating up and down
Mostly high neutrophils, but in most recent monocytes were 987
Platelets sometimes mildly high/high-normal, most recently 444
Hemoglobin normal
CRP 13.9
ESR normal
Ferritin 14

I saw hematology:
Flow cytometry normal
No leukemia/lymphoma seen on flow
LDH normal
Beta-2 microglobulin normal
SPEP/IFE normal
Free light chains normal
Genetic/molecular tests were negative:
BCR-ABL1 FISH negative
JAK2 V617F negative
CALR negative
MPL negative
Other testing:
ANA negative
Rheumatoid factor negative
Thyroid normal
Celiac negative
Abdominal ultrasound: no enlarged spleen or lymph nodes
Fecal calprotectin normal
GI pathogen PCR negative

GI wants to do an upper endoscopy bc they don’t know why my ferretin is so low or why I’m losing weight

I’m wondering what else can cause persistent neutrophilic leukocytosis + elevated CRP + systemic symptoms. Living like this has been miserable :(

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u/Existing_Page_7101 — 1 day ago

Low Transferrin/Iron Binding Capacity, fatigue, weirdly high B12, is this ok?

47M. There seems to be a trend of RBC going down slowly, B12 is going up, Vitamin D was low but now it's good (25-Hydroxy Vitamin - D got cut off, the low numbers are older and not shown), transferrin is a bit low, some of the other ones are a bit low but not horrible. B12 seems to be high but the lab dropped the high end of the range for some reason. I haven't seen a hematologist, none of my doctors see a problem here, in fact one said that low transferrin was a good thing.. All my liver/kidney tests are good so I don't think that could be a cause of low transferrin.

I had some relative with pernicious anemia, but I have high B12 so it's not that and I have other autoimmune diseases. The fatigue may be unrelated to the blood tests, it could be the other diseases or some new possible neurological diagnosis that I might get confirmation on sometime this decade/century. Symptom wise, I'm tired all the time, I fall asleep sometimes while sitting down, standing, talking, using tools, etc. Usually it's just half a second or so at a time. I also think I get a bit of shortness of breath while running/doing something intense (it's not terrible), but I don't do a lot of running anymore.

Edit: I forgot to add one more symptom. My fingernails/toe nails have gotten thinner and split often, length wise along the vertical ridges and my thumb nails are going somewhat concave. So far I've trimmed them before the split gets too far. Not quite as crazy as some of the photos I've seen online but it didn't used to look like that.

u/Horror-Beaver1979 — 1 day ago

Not sure what this means 🤷🏽‍♀️

Can I get some context.
I had a positive? ANA in 2024, my doctor never reached back out to me afterwards. Fast forward to this year I go in for fibroadenoma and bring up the test results. She looked at it and immediately ordered an Ana positive panel and scheduled me with a rheumatologist. I took did the bloodwork last week and these were the results. Since the bloodwork I have felt my symptoms get worse ( severe fatigue, muscle and joint pain, swollen legs, sensitivity to the heat).

I’m not asking for a diagnosis I just want some more insight on the test results and what the are testing for/what questions should I ask my doc.

Also I have my rheumatology appointment in SEPTEMBER. And my pcp just canceled my appointment for today so I am trying to meet with another provider to ask questions.

u/False_Elevator_3777 — 1 day ago

Would iron infusions help?

Looking for some guidance as my normal GP left the practice and I am stuck with an awful doctor that doesn’t provide much help at the moment.

I had a physical with blood work back in November and my doctor said I was iron deficient. Started taking an iron pill (which has b12 and vit c) every other day since then and just went back to the doctor last week because I am bruising easily and feel dizzy sometimes along with some tingling. My iron serum and iron saturation are even lower than November.

Would iron infusions help? I have GERD and gastritis which I know makes it harder to absorb vitamins.

u/HedgehogNew9598 — 1 day ago

29M, low iron, high gastrin, occult blood test, CA 19.9, CEA cancer marker normal, and stomach USG normla. had bloody stool few years back and it stopped, could it be some form of cancer? My doctor not referring me for any scope since the marker and occult blood test is normal

u/IchigoUzumakiD — 1 day ago
▲ 7 r/haematology+1 crossposts

15 years of trying to get answers

These are the results of my recent blood work. I’m currently very symptomatic, light headed, palpitations, etc.

I had an iron infusion approx 11 months ago, in that time my MCH and MCV have never reached normal levels.

I take medication to slow periods, I’ve had tests for internal bleeding and found no answers. From what I can tell, this test confirms that my body just doesn’t know how to get the iron into my blood.

I also have EDS if that has any relation to anything. I’m absolutely at my wits end with feeling rubbish and not finding any ways to improve my iron.

u/grackm — 1 day ago

Recenr blood work

My doctor has not gone over my labs yet and im freaking out because of all these red markers. Im 34/F Can anyone give some insight? Thank you

u/Newhere141 — 1 day ago

Low/borderline HGB and RBC consistently recently

36f relatively healthy. This is my progression of my HGB starting in February, next picture is March, then July 2nd (right before a minor procedure, then July 5 (few days after a procedure).

So recently my HGB has been borderline low and dips down every now and then. I recently got a new doctor who noticed it was low for something else(same hospital system diff department) and said if it comes back low again she’ll order more tests. Well it came back in normal range in March so she didn’t order more testing. Well I recently had minor procedure less than a week ago and they took labs before it and my HGB and RBC dropped again. I ended up getting a bad UTI from them inserting a foley and had to go back into the hospital and they took more labs yesterday, my HGB is normal but my RBC is down.

My procedure was a vein embolization. Literally zero bleeding and everything went normal with that. They don’t even give stitches for the entrance point.

I’m just wondering why my body is having a hard time with iron and stuff lately. It’s always been normal.

I did find out my vitamin D was 13ng/mL, so that was too low and I started a high dose supplementation once a week. That was at my yearly check up in March when all my other labs came back normal.

The only other time my HGB and RBC was low was during pregnancy.

u/Tough_Boysenberry527 — 2 days ago

Blood tests

I don’t think my docs are looking at the overall trends and I’m wondering if there’s something they’ve missed. I know I could possibly have some sort of eating disorder as well at this point and I had an spirometer test this past week that I couldn’t finish, unfortunately I just didn’t feel well enough to. I started out 10 months ago weighing in about 200lbs and my last weight in I was down to 157lbs. Most of the time I feel fatigued and out of breath but not sure how to explain it. Some visual changes as well (already saw a doc and even got updated glasses)

I had wisdom teeth removed a month ago and before that my resting heart rate was sitting at 100 or so and I was almost constantly running a low grade fever. My blood pressure was higher then now as well. Since removal my pulse sits around 63 minus during my test when it shot up a bit. So I suspect getting them removed helped some but I’m not sure is the healing process is contributing to my on going symptoms or if something’s been missed.

They’ve ran some other tests as well I think and I’ve had a few chest X-rays and ct scans. So at this point my heart been cleared.

Not looking for a diagnosis just ideas cause I’m at my wits end at this point.

I can tell a lot of the time when my potassium falls out of range but I know it tends to stay at the borderline of normal.

The two weeks after wisdom teeth removal I did feel like I was getting stronger and was taking a lot of ibuprofen so maybe it’s a inflammation thing but when I mention it to doctors they never seem able to give me a straight answer.

u/Past-Host-4124 — 2 days ago
▲ 2 r/haematology+1 crossposts

Read my blood tests? Causes?

26 yo female, 3 months postpartum. Diagnosis of endometriosis and recurrent ovarian cysts, low ferritin (my whole life). I take nothing. Mostly Whole Foods, homemade diet with no actual restrictions.

I went in for a hysterectomy 2 days ago and these were my labs. Surgeon had them checked 3 times. Has no idea why they are so off. Went into surgery with the idea that we will keep blood on hand but stop the second anything goes wrong - nothing did and surgery was completed with no issues. I have to check in with a PCP to search for underlying causes but I don’t have one, so it will be a few weeks.

Only “symptoms” are random severe bruises, severely dry and peeling skin, hair loss, constipation. All of which could just be a postpartum thing… so idk!

u/crafting_altmom — 3 days ago

(34F) hospitalized with ITP (Platelets <2K for days). Looking for timeline feedback.

Hi everyone,

I’m writing this from my wife's hospital room. We are feeling incredibly overwhelmed and just looking to hear from anyone who has been through a similar timeline or treatment plan. Her platelets have been sitting at <2K for days, and the waiting is agonizing.
Here is a quick timeline of what we’ve been dealing with:

Initial Diagnosis: A few weeks ago, she was diagnosed with ITP. First treatment was IVIG and high-dose dexamethasone. It felt like a magic bullet—her platelets spiked to over 230K.
The Relapse: A couple of weeks later, she crashed again. They readmitted her and tried IVIG a second time, but her immune system completely ignored it.
The "Rule Outs": Her hematologist ran a ton of tests to look for hidden secondary causes. H. pylori was negative. Lupus/Antiphospholipid panels were negative. ANCA/Vasculitis panels were mostly normal/negative. It seems to be primary, highly stubborn ITP.

Current Treatment Plan:
Because the first-line treatments failed, her medical team moved to an aggressive combination of second-line therapies:

Almost a week ago: Received an Nplate (romiplostim) injection (1 mcg/kg). Stopped since started on doptelet.

A few days later: Started Avatrombopag (Doptelet) 20 mg daily pill.
Shortly after that: Received her second IV dose of Rituximab.
Current Status (Day 5 of Avatrombopag / Day 7 of Nplate):
Her morning labs just came back and she is still at <2K.
She had a bad nosebleed a few days ago that required an emergency platelet transfusion (which dropped her hemoglobin slightly), but thankfully she has had no active bleeding since then.
She does have some petechiae on her lips, but no new major bruises.
The medical team keeps assuring us that the treatments are exactly on schedule and that the TPO-RAs just need more calendar days to force her bone marrow to out-produce the destruction. They say sitting at <2K on Day 5 of the pills is expected, but waking up to that same number every morning is gut-wrenching

My questions for the community:

⁠Has anyone else been on a combination of TPO-RAs at the same time as Rituximab? Whats the timeline for the first positive response?

⁠Any feedback, similar stories, or realistic timelines would be incredibly appreciated right now. Thank you.

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u/Former_Ranger_20 — 3 days ago

could someone look at my blood work and help me figure out what's happening?

F, 15, 170cm, 92kg (13kg lost since early may), non smoker, i only have psychological conditions that i'm aware of rn, nothing else.

my blood test but i did end up translating some screenshots because it wasn't in english..

hi! i got blood work done a few months back but every time i go to the doctors its really busy, so no doctor has really explained much about my results. i was wondering if anyone could take a look and tell me if anything stands out or if something might be wrong?

my symptoms are fatigue, depression, anxiety, and getting dizzy whenever i stand up. i lose my vision for a few seconds after standing, even if i dont get up fast i also get frequent headaches, usually around my eyelids? even the most simple things become exhausting after just a few minutes, and my whole body feels like its aching.

as for my medical history, my mom has thalassemia, and there's a family history of diabetes.

i also don't go outside much, and my diet is pretty inconsistent, so i'm probably not getting all the nutrients i need.

if there's any other information that would help i can say it, thank you, please be kind:)

u/offrisperidone — 3 days ago

Why is my anemia not improving after 7 transfusions.

These labs are from January to

Now and ive had 7 transfusions before the latest results which are the 1st picture. Why is my anemia not getting better and seeming worse actually

Ferretin is now an 9 from a 13 originally as well.

u/divorcedaywillbexmas — 5 days ago