u/Independent_Fly_9920

I am here to tell my story about the past 7 months I have lived alongside Mycoplasma Genitalium infection. The story is long but I hope that it’s useful for you.

I am a European nearly 30 years old white straight male. No pre-existing conditions or medication. No depression or any anxiety in history. What’s also reasonable to take into account is that I am a general practitioner (medical doctor) by myself.

In early October 2025 I started to develop urethritis symptoms: white discharge, discomfort in the penile area, dysuria, feeling that something is moving in my ureter. I recognised these on the same day and knew they were urethritis symptoms and went to test for Chlamydia and Neisseria. They were negative so the next day I went for Mycoplasma Genitalium test and immediately started Doxycycline 100mg x 2. Mycoplasma test result came back positive and later on the PCR result showed resistance to macrolides and fluoroquinolones. I contacted my local STD expert and I was told to use doxycycline 100mg x 2 for 14 days and not to test again if I’m symptom free. The discharge and dysuria relieved towards the end of the course but didn’t stop and didn’t get completely clear. I felt like the infection wasn’t cured because of dysuria and discharge. I had a couple of days without antibiotics and contacted the doctor again. Now I was prescribed minocycline 100mg x 2 for 14 days and I started the medication immediately. Minocycline also relieved my symptoms maybe a little bit more than doxycycline. There was only a little amount of clear discharge towards the end of course, not white anymore. The dysuria went away.

It was very hard to be objective in my situation and on a daily basis I pinched and put pressure on my urethra because I felt that something was moving in my urethra all the time and I tried to find out if the white discharge was back. The discharge was mainly clear for a couple of days after the end of the minocycline course but there were white lines in my precum which made me suspicious.

Almost 2 weeks went by and the dysuria and white smelly discharge came slowly back. Also this time my pee was completely cloudy and barely you couldn’t see through that. The discharge was constantly leaking from my urethra even without any pressure. The dysuria was unbearable. The control test was positive. This was mentally crushing me. All the other symptoms like the feeling that there is something moving went away for a while though. Basically, I had run out of the evidence based available options. I started to plan on getting pristinamycin and got it. On January 2026 I got pristinamycin and started with 7 days for doxycycline 100mg x 2, then 10 days doxycycline 100mg x 2 and pristinamycin 1g x 3 together and then 10 days doxycycline 100mg x 2 again. The white discharge went away again but during the treatment the constant feeling that there is moving something came back and was very strong. I had major difficulties thinking about anything other than the infection and I kept bouncing the nightmare scenarios again and again in my head. I was so hopeless that I wanted to keep treating myself and contacted my STD doctor again. I just wanted to maximize the possibility of getting rid of the infection. I suggested trying minocycline for 14 days + metronidazole for 14 days and after that to continue minocycline for 14 days in a row. We came to an agreement and I accepted the risks that come along with the treatments. I used the medication and to be honest, there was no big change in my symptoms. Also during metronidazole, I got major anxiety that almost paralyzed me. There was still some penile pain, some clear but not white leakage from my penis. My pee also got clear which was a good sign if you think about the urethritis. There was some secretion that looked like a floating spiderweb in the urine but for me it didn’t look like a purulent discharge. I also read about chronic prostatitis at this time. I know the disorder because of my job and degree but somehow it hadn’t come to my mind because, again, it has been very very difficult to be objective when it comes to your own health. Most of the constant penile pain relieved in 30 minutes after I figured out that it might be prostatitis aka chronic pelvic pain syndrome (CPPS) and all the symptoms that I was suffering from just couldn't be related to urethritis only.

On the 25th day on minocycline (15th March) the white discharge came back in the morning but only once. Nothing after that. However, this caused me massive anxiety (again) and I felt like I was falling into general anxiety disorder. I had tried everything. I felt like my life was over. I felt like the bacteria had some intelligence and ability to avoid every treatment that exists. I felt like I was beaten. I felt like I was losing my mind without any psychiatric background before.

Feeling that I had lost the battle I called my doctor again. She wasn’t that worried at all about the situation and told me that this is a very typical scenario and actually would be surprised if that long infection wouldn’t cause any problems to your pelvic area. She wasn’t worried at all about the white discharge that occurred only once but didn’t continue. Her suggestion was pelvic physiotherapy. I was so so so relieved. I stopped thinking about the situation continuously, I didn’t watch the quality of my pee every time, I didn’t put any pressure on my penile area anymore because if there was discharge it would leak out without pressure and I would find it out at some point during the day when I go to the toilet etc. The symptoms relieved more and more day by day. I also visited a very recognized urologist in my country and he assured me that the remaining symptoms are related to pelvic floor tension which causes pressure on my prostate and that radiates to the penile area.

Now it is a little bit easier to think about the situation objectively and I am quite sure that continuous white discharge, dysuria and the very cloudy urine were symptoms related to urethritis. However, the constant penile pain, some pain in my testicles, discomfort in my perineum, feeling cold in the tip of my penis, mild trouble in peeing are symptoms that are most likely related to chronic prostatitis aka CPPS. Though some dysuria and whitish but clear secretion (spider web look-a-like) can be related to CPPS also because your prostate leaks some fluids sometimes. At the moment, there is no need to test me again. The urethritis is very likely gone. I have only mild and rarely occurring residual symptoms left.

My recommendation for you that are going through the infection or CPPS symptoms. Read them carefully:

Do not focus on your symptoms all the time. You are making them worse. The disease comes greater than it is if you let it control your thoughts. It infects only a very small area of your body, not your brain. Stay in close contact with the professionals if you are losing your mind. Don’t doom yourself if the professionals don’t do it.
It is very likely that you have CPPS at the same time or only if you are having any other symptoms than white constantly by itself leaking discharge. Please, contact a professional pelvic physiotherapist or urologist.
Please, treat yourselves evidence based. This forum might be important peer support for you but this forum doesn’t rule over guidelines. It was very difficult for me also because I was so desperate. I can’t suggest that you should use all the antibiotics available in a row like I did.
It doesn’t have any supernatural powers. It is curable. It can clear spontaneously also.

During this nightmare journey I have probably read all the relevant peer reviewed scientific publications about Mycoplasma Genitalium and my theoretical knowledge is probably one of the best in our country about the issue but my limitation is that my only experience of patients with Mycoplasma is myself.

For the next week I will answer the questions and take part in the following discussion if you want to comment on my story. Then I will leave this behind me and hopefully I will not have to think about this ever again.

Good luck all.

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