I’m looking to nanodose but I understand Pharmscies usually wont go super low dose so I will dilute. But.. I presume one can find pharmacies at .1mg ? Any suggestions ? I looked at the group doc but I believe its US focused?

Many thanks :)

If you split dose, at what intervalls and what dosage do you do so?

I started to microdose for pmdd / depression / inflammation, and I‘m still newish at it, but I realized 0.33mg down til about 0.3mg seems to be my sweet spots. When I take it 3-4 days apart, I think I need to calculate in that it may take 1 day to fully ramp up in my body, while obv. at the same time some of the last dose dissipates. I‘m not yet sure how to best go about this without going too low or high.

What works for you ?

Hi, I microdose mounjaro for my pmdd like symptoms and for inflammation.. for now I sit at 2x week. I find the calculstion not that easy.. which makes me ask - how do you go about it? I want to ideally be at .33mg highest and at .3mg lowest..

I deal with an overactivation (SEP language) in my NS plus perimenopause and a burnout.

I do SE/Feldenkrais regularly.

My body keeps talking to me and telling me daily its overwhelmed. Its very insistent. For context; I don‘t hold a job atm, my focus is relaxation and recovery and enjoying the summer (laughter, friends, etc.).

I also have tmj & neck stiffness.

I‘m looking at this from a medical, physio & longevity (biohacking) perspective aswell.

One route I‘ve come across would be to try microdosing LDN as it seens to help to bring an overstressed nervous system back to baseline abd not just ‚mask‘ symptoms. It does that for IBS, autoimmune issues, MCAS and so forth. But asking in that sub, I had no luck getting insight if my issues could be helped.

Anyone experience with LDN in a similar context ? Or any other ideas ?

I am in peri and progesterone and estrogel & vaginal estrogen keep me going (in combo with Intuniv) - I can‘t take stimulants.

My workouts are great, thanks to progesteron no muscle pain and since I’ve optimized my estrogel my recovery time decreased even more. Libido is soso.

But my executive function keeps on tanking by a stellar rate, I used to get to a point where I said ‚enough‘ but somehow this point is not reaching me at all. I‘m often tired. I am looking into if I have any hidden thyroid issues atm, as the usual tests show I don‘t, but my PME (PMS type of emotional symptoms) is off the charts if I forget my hormons and my thyroid often hurts.

From an adhd perspective I‘m the combined type.

So this makes me wonder, if low Testosterone could be involved? What‘s your experience?

Hi All

I‘m looking to bring my nervous system gently out of deep chronic stress (fight/flight). Somehow I landed at LDN but find it hard to decipher if this would do the right thing, hence thought I ask:

- Very deep bodily exhaustion (no chronic fatigue) but my body tells me daily its overwhelmed (I‘m not working atm and in somatic experiencing therapy. I‘m rechecking my cortisol values but I‘d be surprised if much would show as I lead such a health oriented lifestyle, take all supplements aligned with longevity specialists etc.).

- Waking up every morning with a stiff neck (also jaw) and yes I take all the magnesium & Guanfacine, which helps somewhat

- MCAS types (?) of issues resulting in loads of food groups not being well digested & some left side ear/shoulder inflammmation and pmdd types of symptoms (I‘m looking into hidden underlying Thyroid issues in parallel)

- Peri & increased emotional dysregulation (on HRT)

So I started to nano/microdose a glp-1 and it seems to gently start working for some of these issues. Though I still wonder if the deep stress state (exhaustion & muscle tension), my system seems to be in, could be safely targeted with microdosing LDN ? I would want to avoid further emotional dysregulation ofc.

Thank you for any insights 🙏

Ok, stimulants and me don‘t agree half of the time. SSRIs I need to keep increasing, plus destroyed my gut health & metabolism (histamine & estrogen anyone)..

As i also have rsd, I finally tried directly guanfacine (awesome for rage, tmj, etc), which frankly 👌 but with naturally low blood pressure.. and peri in the mix, the 2mg ain‘t enough to deal with bigger rsd triggers. (adult dosage is on average 4-6 or even 7mg/day.

HRT helps but also still not enough if there are triggers.

Had initial success with antihistamines, but yesterday that was like drinking water 🤦‍♀️ it did absolutely nothing (pepcid & a claritin).

So thinking of mastcells, peri, peri rage, low serotonin, crying spells, low blood pressure, possible underlying thyroid issues (my longevity doc never found anything but I‘m getting a scan now, so lets see).. resulting in ED, inflammation, pmds like symptoms, I am landing at LDN.

Haven‘t tried any other non stimulants..

Started a nanodose of Mounjaro, to be seen if it helps or makes things worse.

Anyone with a similar profile and what did you end up combining ?

I really want to get a solution for:

- rsd, limerence
- inflammation,
- executive dysfunction, low serotonin
- anger, tmj (guanfacine fixes this for now)

Hi All

Background:
I don’t eat/avoid foods with gluten, lectins, cassein, soy nor histamines. If I slip, I don’t get into shock but its still not very pleasant (pains, emotions), but I sometimes do for getting dopamine or pmdd or stress reasons.

Issue:
Now I started micro/nano dosing (.14mg) mounjaro (glp-1) and for the first time in a long time, I got reflux a few times. I want to nip this in the proverbial b* before it becomes a real issue and it forces me to stop the glp-1.

Question:
I take a lot of supplements in alignment with a longevity specialist/dr but for whatever reason I don’t have any digestive enzymes.. so I thought I ask in here as you might take smth that fits my needs.

Hi all

Starting this for inflammation and hence very low. I have it all ready at home, kiwipen at 2.5mg and Ultra-fine pen needles. I also got this calculator https://getdosewise.com so so far, so good.

Idea is to start with .14mg, which equals 3 clicks.

But - I read smth about the first 2 clicks do not contain anything ?

Can someone clarify this for me ?

Many thanks

There’s a hormone your muscles release when you do intense exercise.

In 2012, harvard university found something. They called it Irisin. After iris the greek messenger goddess.

In a literal sense, it carries the signal from your muscles to your brain.

And that message is.

Build.

What it does

In animal studies, when irisin reaches the hippocampus, the part of your brain tied to memory it activates pathways that increase a protein called BDNF.

BDNF is what helps build new connections, keeps neurons alive, and supports the creation of new ones.

It’s basically part of your brain’s maintenance system.

In humans, this pathway seems to exist too.

But it’s not clean.

A lot of it is stitched together from animal work and indirect human data. The direction is pretty clear. The size of the effect isn’t.

Still, the idea holds:

Your muscles, send a signal that appears to keep your brain itself intact.

What triggers it

Intensity.

That part shows up again and again.

A 2024 study looking at this pathway found a pattern. At lower effort, the signal is weak or inconsistent. As intensity goes up, the response becomes more reliable.

It’s not a clean switch.

But it leans one way:

Push harder = stronger signal.

Walking still helps your brain.

So does light movement.

They just don’t seem to drive this specific pathway very hard.

If you want this muscle to brain signal, you probably have to go past comfortable.

Cold exposure

Cold seems to tap into part of the same system.

A 2014 study showed that cold exposure increases circulating irisin in humans.

Same hormone but different trigger.

What has not been proven yet, but may in the future.

That cold - BDNF - better cognition chain in humans.

The overlap in pathways is real.

The interesting thing is If you can't train hard due to various reasons, there might be another way to get part of this signal to the brain.

Where the irisin story went wrong

Early on, most of the hype came from mouse studies.

Those studies used doses far higher than anything a human body produces.

Then came the measurement issue.

Early human studies used an antibody test that was not specific, they picked up on the wrong proteins.

So the numbers looked bigger than they actually were.

In 2015, researchers used mass spectrometry, a much more accurate method to measure irisin in humans.

Here's what they found:

Sedentary people: around 3.6 ng/ml
People who train: around 4.3 ng/ml

That’s a real difference.

But not so huge.

Nowhere near what the early headlines suggested.

So the honest version looks like this:

The hormone is real.
The pathway is real.
The effect in humans exists but it’s modest.

Which means exercise matters.

But it’s not the whole picture.

The other problem

Even when the pathway is there, it doesn’t operate on its own.

Insulin resistance lowers BDNF.
Chronic inflammation lowers it.
High cortisol lowers it.
Oxidative stress lowers it.

So the people who may need this signal the most…

often have the weakest response to it.

That’s the bottleneck.

The second pathway

Your brain doesn’t rely only on muscles.

It can generate its own signal.

Cognitive challenge, done properly can increase BDNF without any muscle involved.

No sweat needed. Just difficulty.

Push your brain hard enough, and it responds.

The trial most people missed

The ACTIVE trial.

2,802 adults over 65.

Started in the late 90s.

They were split into groups:

• memory training
• reasoning training
• speed-of-processing training
• or nothing

Each group trained for about 5-6 weeks.

Some got follow up booster sessions about a year later, and again at three years.

Then they waited.

For twenty years.

The follow up came out in 2026.

Researchers looked at medical records for just over 2,000 of the original participants.

Most had died by then. Average age: mid 80s.

The result:

The speed-of-processing group that got boosters had about a 25% lower risk of dementia over 20 years.

Roughly 40% developed dementia versus 49% in the control group.

Memory training didn’t show a clear effect.

Reasoning training didn’t either.

Speed training alone wasn’t enough.

Only the combination short training plus reinforcement over time made a difference.

This is one of the few long term randomized trials showing any reduction in dementia risk.

Not drugs.

Not supplements.

Not diet.

Training.

Done in a specific way.

And not Wordle.

Not Sudoku.

Not the generic brain apps.

This was adaptive training that got harder as people improved.

Two pathways

Most people are using neither very effectively.

One pathway is physical:

Intensity → irisin → BDNF

The other is cognitive:

Adaptive challenge → BDNF

Most people walk
and do light puzzles.

Both are fine.

They just don’t seem to push either system very far.

What to do

If you’re young and healthy:

Push intensity.

Sprints. Intervals. Heavy lifting.

Cold exposure can help, but it’s secondary.

Check your vitamin D.

Low levels may reduce FNDC5 — the protein that turns into irisin.

Which means the same effort could give you less return.

If you’re older or can’t train hard:

The cognitive pathway has stronger long term outcome data.

Not casual games.

Adaptive training that forces you to improve.

And it probably needs to be repeated over time.

If you’re in the middle:

Use both.

TLDR

Your brain needs repeated growth signals.

Modern life strips most of them away.

We move, but not intensely.
We think, but not deeply.
We stay comfortable.

Exercise gives you one signal.

Cognitive challenge gives you another.

Irisin exists.

It was identified in 2012.

It’s measurable in humans.

Its role in brain health is promising — but still being worked out.

Most people have never heard of it.

Now you have.