r/GLP1microdosing

Just wanted to share my experience with microdosing tirzepatide so far!!

I'm totally new to the GLP-1, and am trying to lose a few pounds. My biggest reason isn't even just the weight loss, its the food noise. I felt like I was always thinking about food and dealing with cravings, even when I wasn't actually hungry. Dieting was really hard for me because of that.

I did a lot of research and ended up going with Fridays because the reviews were pretty good and it fit my budget. I was originally going to go with Noom, but they offered me a really low-dose plan. Apparently this is a new plan they have? and from what I understood you can't change it. Since it was also more expensive, it just didn't seem worth it to me. I was also looking for a provider that would be okay with prescribing a microdose since a lot of them have BMI requirements.

For anyone wondering, I ordered on 6/24 and my vial arrived on 6/26, which was pretty fast. You inject once a week, and I've only done two injections so far, so I obviously can't speak on long-term results yet.

So far I haven't had any side effects (at least for now lol). During my consultation, the doctor did tell me that side effects are pretty uncommon at a microdose.

I noticed the appetite suppression the day after my first shot. The biggest thing I've noticed is that I get full way faster, and I don't think about food nearly as much. I still get cravings sometimes, but they either go away pretty quickly or I'm happy with a small portion instead of wanting to keep eating.

Overall I'm really happy with how it's going so far. I figured I'd post this in case anyone else is in the same boat I was!

Happy to answer any questions!!!! I also have a referral code if anyone needs it. I actually used someone else's referral code lol, so my first month ended up being $78.

Hello everyone,

This morning (about 9 hours ago), I took my very first dose of Mounjaro/tirzepatide - 1 mg. I decided to try microdosing since I only have around 6–7 kg (13–15 lbs) to lose.

It’s still too early to tell if anything has changed. After the injection, I had a light breakfast, and a few hours later I got really hungry (probably because I went for a morning run). I ended up having a big lunch with a friend, including dessert. So far, I haven’t noticed any appetite suppression at all.
That said, I know it’s very early, so I’m not jumping to any conclusions yet.

What was your experience like? When did you first feel it kick in? I know everyone responds differently, but I’m curious to hear your stories. Thank you!

Hi! I started with .1 mg once a week and then upped to twice a week however, on the 2nd week of 2 injections, I got so nauseous and dizzy the day after my 2nd injection that I was in bed for 1 full day and still feeling ill a 2nd day. I was also cycling 10-15 miles a day, so I am not sure if I had heat exhaustion with the high temps we've had in the midwest, or if it was from the 2nd dose that 2nd week week. Has anyone else experienced this? I really think it was from heat exhaustion, but now I'm nervous to go back to 2 doses a week. I will definitely discuss with my Dr at my next visit, but I wanted to know now if others have had this happen as well.

I’ve been on a GLP-1 medication for eight weeks now and I’m still on the starter dose of 2.5 mg. So far, it has been working really well for me: I’m losing weight, I have much less food noise, and I find it easier to make healthier choices. I’m also going to the gym regularly, so overall I feel like things are moving in the right direction.

One thing I’ve noticed is that it seems to have reduced my alcohol intake too. I used to struggle with binge drinking, and compared with how I used to drink and behave on nights out, I would say my alcohol consumption has probably reduced by around 50%.

At first, it felt like the medication really took away the desire to drink. I just did not feel particularly interested in alcohol. But I’ve realised that when I’m out in certain social situations, there is still a learned habit there: ordering drinks, staying out late, and chasing that buzz. So it has helped, but it definitely has not completely switched that part of me off.

What has surprised and frustrated me is that although I am drinking less, the after-effects seem much worse. For example, last night I went out around midnight and stayed out until 5 a.m. Over those five hours, I had six standard drinks in total: two beers, one shot, one double gin and tonic, and one single gin and tonic.

I went to bed at 5 a.m. and woke up around 10:30 a.m. feeling extremely dizzy, still drunk, nauseous, exhausted, and with a really bad headache. I was so wiped out that I went back to sleep. I spent most of Saturday asleep or dozing on and off, briefly watching YouTube and then falling asleep again. I got up late in the afternoon to eat something, then went straight back to bed and slept through Saturday evening into Sunday.

It genuinely felt as though I had lost an entire day, even though I had only had six drinks. I was invited to a few things on Saturday and had to miss all of them because I felt so awful. It is strange because I am drinking much less than before, but it feels as though alcohol is affecting me far more strongly now.

Has anyone else experienced this on GLP-1 medication? I’m grateful that it has reduced my drinking, but part of me wishes it worked strongly enough that I simply did not want alcohol at all, or that I could comfortably stop after two or three drinks.

I also wonder whether a higher dose would help more with alcohol cravings. At the same time, 2.5 mg is already working for me in terms of weight loss and appetite, so I do not feel like I should increase it just for that reason.

I’m not using for we that loss but for MCAS. How many units should i start with fir trizepitide
My vial is 18ml/4ml vial
Thank you

For context, I am not overweight. I am 25, 5'5.5" and weigh 150lbs (female), just on the cusp between a normal weight and slightly overweight. Great measurements, 28" waist, so on. Nothing is immediately concerning. I've had a big weight loss (190 to 135 after treating hypothyroidism) before and generally know what I'm doing and it's not working for a few reasons.

Since October, I have gained about 15 pounds eating the same stuff I always do (even cutting back). However, the change is not exactly something within my control. I was diagnosed with a rare heart disease called ARVC in January and had surgery for an ICD implant. I used to be on Vyvanse for ADHD management, but due to this condition I had to stop and was instead put on Metoprolol, which often causes weight gain by changing your metabolism/lowering HR. Absolutely cannot get off Metoprolol or take Vyvanse again, this is critical to management of my disease so I do not die.

My heart irritability/ectopy/PVCs are also contributed to by, you guessed it... hunger/fasting. Dehydration. Electrolytes being off. Ah, wonderful for me.

Worse is that because of my ARVC, I literally cannot exercise like everybody else. Like, legitimately. I can do stuff like normal walking, maybe very light lifting, but my HR isn't supposed to go over 140 or so.

I feel trapped watching the number on the scale slowly go up when there's not much I can do about it aside from eating very little, which only makes my heart (and mind) madder. I do have a PCP who I talked to briefly about regarding this issue and she said if I continue to gain weight she'd be willing to prescribe a GLP-1 because of my unique situation, though it'd obviously not be insurance-covered.

I feel like this is a situation where a bit down the line, if it's not my thyroid causing issues or I can't maintain my weight (though I'd prefer to be 140lb)... GLP-1s and microdosing might be warranted. I absolutely do not have diabetes (A1c is like 5.3, cholesterol good) and am not even overweight and my weight distribution is healthy but I'm terrified of what may come over time if I just let things drift. I do not want to be overweight again. The idea terrifies me, I felt terrible when I was overweight.

How exactly do you guys start with this stuff? Where do you begin? At what point is the microdosing officially considered 'warranted' since I'm not actually overweight yet? I can afford a few hundred dollars per month but I really can't afford thousands monthly and I'd like to avoid large dosing if possible so I don't like... I don't know, barf over literally everything like my dad on Ozempic does.

Thank you guys in advance for your help/suggestions!

Is anyone holding at 0.25mg? Thinking of doing it just for the inflammation but curious for those running at 0.25mg how many side affects and appetite suppression you get (I’m not looking for any).

If not anyone stay at 0.5 and can share their experience?

Where are the brave souls that have experimented past 15 mg dose? Anyone on a five day shot schedule on max dose? Would you recommend it? Any cautionary tales?

Basically the title. Looking to hear from anyone who successfully stayed on tirzepatide because oral minoxidil eventually stopped/recovered the hair loss.

Specifically, I’m looking to hear from people who had what seemed like drug-induced TE from tirzepatide, not hair loss from rapid weight loss.

My shedding started almost immediately after starting tirzepatide (started at .5 currently only at 1.5mg), and over the last 4 months I’ve lost what feels like half my hair. It’s been pretty devastating.

I started 1.25 mg oral minoxidil 5 weeks ago, but I’m in what I assume is the dread shed, and it’s honestly worse than before.

For those who stayed on tirzepatide while taking oral minoxidil:
\-Did the shedding eventually stop?
\-Did your hair grow back while staying on the medication?
\-Or did you have to stop tirzepatide for things to improve?

Please don’t suggest protein, iron/ferritin, thyroid, or slower weight loss. I’ve already addressed all of those, and I’m specifically looking for experiences with what appears to be tirzepatide-induced TE.
I’d especially love to hear from anyone who was able to stay on tirzepatide and eventually recover their hair with oral minoxidil. ❤️

Getting ready to order pen needles for kwikpen on Amazon. There are so many options and I’m showing they all are compatible. So I assume it comes down to preference or maybe you just pick your favorite color 🤣

Which do you prefer and why?

Is there a difference between brands or just size?

I'm reducing my tirzepatide dose because I don't like the effects on my heart rate/HRV. My doctor titrated me up to 15mg right away and I don't think that was a good idea for me. I know that I will have to stay on it at some level because it's improved my life so much, but I want to reduce it. I think I can manage my appetite at a micro dose now that I'm in maintenance, but I'm scared of losing the inflammation benefits. Are you guys still having inflammation benefits on a microdose? If yes what dose are you at?

I have been reading certain research saying the efficacy of Glucagon receptor of retatrutide is based on Peaks, unlike the GLP and GIP receptor which depend on concentration and saturation.

Let's say a person decided to take 5mg retatrutide weekly.

Scenario 1: 5mg taken on Monday as a single shot but it leads to a little GI upset.

Scenario 2: Split dosing, 3mg on Monday, 2mg on Friday.
No side effects felt at all.

Main question is, will the split dosing reduce the overall efficacy of the peptide? Moreover, is it actually true that glucagon effects are most pronounced if taken as a single high dose?

Hey guys,

Has any one had eye issues while taking glps? I have had blurred vision and sensitive to lights and dry eyes.

My eyes have adjusted back to normal now but curios to hear if any one else has had these side affects? Im scared to do it again to be honest but it works so bloody good.

I started microdosing tirzepatide about a month ago. I have slowly worked my way up and am now on 1.25 mg. I have been on oral birth control for > 15 years.

I understand the risk of normal dosing of tirzepatide decreasing efficacy of OCP and increasing chance of pregnancy.

My provider stated 1.25 mg is a low enough dose that I don’t need to worry about back up contraception unless I go up to 2.5 mg. I am getting it through Everwell pharmacy which is accredited so hoping I truly am only getting 1.25 mg.

I am looking for anecdotal experiences for those who microdose, any unexpected pregnancies or signs of decreasing birth control absorption?

I have my vial is 18ml/(4ml vial)
I’m wanting to start low. It’s little confusing though so anyone that can help please let me know?

Hi all,
Can anyone recommend someone that compounds Tirzepatide with glycine? I have B vitamin issues so I need to stay away from them.
AltRx, Trinity is B6/B12 from doing research.