r/GLP1microdosing

I am not very versed with this, and i have a lot more weight to lose than someone who is within normal BMI, im 192 and im trying to get to 150, and i go to the gym regularly but plan to add in some other supportive measures as well, including diet change with the help of the food noise reduction. but i would like some perspective from others. I was planning to start low and go slow, beyond just the weight loss, i have insane sugar cravings constantly its overwhelming everyday. The prescriber mentioned something about my waist measurement being the main qualifier, which was the first time i heard that. I know gym and exercise and the right foods to maintain minimal constipation. I am a BMI of 28 after rapidly gaining 40 to 50 pounds after developing a mucinous cystadenoma. I tried and tried to lose the weight. No joke i tried it all. So someone dear to me said to just try a microdose.

Can someone just give me some perspective? I'm just a tad nervous. I was considering starting at like 0.1 mg (just to let my body progressively adjust), and was also curious what your guys recommendations are for scaling up from there. Should i stay on it a week? Two weeks? a month? before going to 0.2, then if its not helping how long after that? I apologize for the messy rant here.

currently at an 38E and would like them smaller (NOT the reason i’m taking this at all (i’m taking this due to actual health issues), but would be a nice extra perk if it were to happen) do your boobs get smaller with the glp-1?, is it different with everyone, or do they only get smaller if they were there that big due to fat and not genetics, because if so i’m screwed lmao

I am microdosing Tirzepetide for a variety of metabolic reasons and to lower inflammation.

Clinical trials have proven it can SLIGHTLY reduce total cholesterol, LDL, and triglycerides.
Thats an added bonus. After being on it 10 weeks, I love it. I hope to be on it or something similar for life.

Tirzepatide is NOT only a GLP-1. Tirzepatide is a DUAL GIP and GLP-1 receptor agonist, meaning it is both. Dual Agonist: Tirzepatide is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist.

There are people like me who are taking a low dose for metabolic reasons, inflammation, MASH, kidney protection, joint pain reduction,
osteoarthritis and increasingly MANY other health conditions.

I lost about 10 pounds and I am stable at my current weight. My BMI is 20. I am on a maintainence dose. I am not taking it to lose weight .
My physician approves of me taking it as long as I don’t become underweight.
I plan on staying on this indefinitely! ❤️

I am aiming to start on 1 mg Tirz for both physical and mental health purposes, I also only have about 10-15 lbs to lose and I feel like I would benefit most from low and slow. I know everyone's journey is different and someone might feel the impact of a dose as low as 0.5, while someone else might need quadruple that to start seeing results. Has anyone here started and stayed on 1 mg and experienced any weight loss, reduction in food noise and inflammation and any othr benefits, or did you have to titrate up?

I am completely over the moon. People seem to forget this drug was initially created for blood sugar control.

I took the initiative and put myself on this drug. I am on it primarily for inflammation, metabolic issues, osteoarthritis and blood sugar control.

I love it!!!!

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I've not lost any weight in 14 weeks and I'm feeling a bit fed up. When I started dosing 1mg once per week I lost a few pounds but I also had not very pleasant anhedonia so after a month I learnt about split dosing and ended up dosing every 5 days and no longer had an side effects.

I'm now up to 1.75mg and have appetite suppression still but no weight loss, and I'm eating a lot less. I read in another sub that someone who plateaued at dosing every 5 days switched back to 7 days and it seemed to kick start their weight loss again.

I'm just worried I might get anhedonia again from having such high peaks and lows, but maybe my body is used to it now? I guess I can try but the other question is how much should I dose every 7 days? As if I'm dosing 1.75mg would I then need to increase it again to a bigger dose? Or should I stay at that dose and see how I go? I'm just worried I'm throwing money down the drain.
I'm perimenopausal but just quit hrt as I was worried it might be why I've been gaining weight since I started taking it.
I'd just like to hear from people who've gone back to once per week and found it helpful.

I started my Mounjaro journey back in November 2023 and have been incredibly lucky with it overall. I stayed on 2.5mg the entire time and lost the 12kg I wanted to lose within about 6–8 months. That dose was then enough to maintain my weight really well for many months.

The problem was tolerability. My blood pressure would often crash after my injection and I’d feel exhausted for a few days afterwards, sometimes with quite a low mood too. I initially tried spacing my injections further apart, but that wasn’t ideal either, so about 1.5 years into my journey I started experimenting with microdosing.

I’ve tried a few different doses and intervals since then and, for a long time, managed to maintain my weight perfectly while avoiding the side effects, woudl only shift up and down a few 100 grams for a long time, I was sailing!

But something seems to have changed over the last 6 months. It just doesn’t feel as effective as it used to, and I’ve gained around 1–1.5kg that I simply cannot seem to shift. I know that’s not a huge amount, but what worries me is whether this is the beginning of the medication becoming less effective for me.

At the moment I’m taking 1.7mg every 6 days. I moved from every 7 days to every 6 days to increase my overall exposure slightly without increasing the actual dose too much, as I really don’t think I can tolerate a significantly higher dose.

I’m 54 and menopausal, so I’m very aware that hormones, body composition and metabolism can all be part of the picture. At the same time, I was already dealing with hormonal changes when I originally started Mounjaro and it worked incredibly well then.

Has anyone else who has been on a low dose/microdosing long term experienced something similar, where it suddenly seemed to lose some of its effectiveness? Did you manage to get things moving again without dramatically increasing your dose?

I’d really love to hear what worked for others, especially anyone who had side effects that prevented them from simply moving up the usual dosing schedule. I’m trying not to overreact to 1–1.5kg, but I’d like to understand what might be changing before it turns into a bigger regain.

Thanks

For inflammation (not weight loss) what dose is everyone on here? I really had no side effects and I had more energy today than I would’ve without the medicine and so I’m thinking to just increase my dose next week .4mg or .5 mg because I could use all the anti-inflammatory benefits that tirz can provide.

Also, another question, the more you increased your dose, did you get more anti-inflammatory benefits for your autoimmune condition? Was there ever drug resistance?

I don’t wanna get to the point where I have a lot of appetite suppression and some of the bad side effects like constipation. That would not be fun.

This might be my miracle drug and I really hope it is for some of you for its anti inflammatory benefits. It’s a no-brainer that it’s a miracle for weight loss, but I’m wondering for other conditions as well.

I can already tell that I will need to take this medicine for life.

Thank you in advance for all of your input.

Hi all -

I titrated up to 1.2mg of compounded Tirzepatide. I took the injection last Friday. Today is Thursday and I’m still feeling nauseous. I had mild nausea at lower doses but it would last maybe 2 days max.

I also am battling a cold so wondering if that’s affecting it. But WWYD? I’m due for next shot tomorrow and am tired of feeling sick to my stomach. Bump back down to 1mg? Skip a dose this week?

If you’re fine on your starting dose after 7 days - ie no side effects or beneficial effects, would you go up the following week or wait? 🧐

I have Long COVID with MCAS, dysautonomia as well as a terrible metabolic profile - A1C is over 6, LDL is 192. The McAS makes me hyperactive to various medications. I’d like to microdose but I read anecdotal parts of people having bad mast cell flares. I’m hoping that by Microdosing I can avoid that.

After talking with my doctor, I have decided to microdose tirzepatide. I am 51 years old, 5' 10" 195lbs. I am active and I have been suffering inflammation issues predominantly in my hands, wrists, and elbows. My CRP = 7.6 (high), glucose 107 (borderline prediabetic).

I have a 30mg vial arriving soon and I plan on starting at 1mg per week. I plan on reconstituting with 3ml of bac water.

Any tips, thoughts, or information you want to share?

Hi,
Just wondering how most people up their dosage. I’m at 0.5mg/week and I think I’m going to go up to 0.75 or 1. I’m debating doing 0.5mg 2x/ week as opposed to 1mg 1x/week. I know I can always play with the schedule and dosage but I’m curious what most people do? Thanks!!

This stuff is amazing for my ADHD. I think I have a little bit anxiety, but I have the push and wanting to get tasks done off my checklist. I’m able to finally start tasks. Anyone else experience this gosh my ADHD was a bit debilitating before.

Also, if it helped during anxiety, share your experience thank you in advance

It’s only day two and I noticed it helping anyone else have the benefits for ADHD so fast