r/GLP1microdosing

(THIS IS NOT AI. I feel the need to say that in this age of Reddit)

I am a 20 year old guy. I have been into fitness and nutrition for about six years. My goal has always been to be lean, muscular, and in shape.

At the end of high school and beginning of college, it got to a point where food and exercise ruled my life. I struggled with binge eating and over restriction.

I started microdosing retatrutide in July of 2025. Two months ago I switched to tirzepatide (Zepbound).

My experience was immediately very positive. It is so relieving to have more mental space for things other than food. I have gained muscle and lost fat over the last two years. I do not eat in a caloric deficit all of the time. Usually, I am eating at maintenance or slightly above. For reference, I started retatrutide at 146 lbs. In September of 2025, I was 139 lbs. My weight crept back up to 146 and held steady, but I looked COMPLETELY DIFFERENT.

This summer, I have intentionally gained some weight. Now I am 149lbs, with significantly more muscle than when I started on these drugs.

Glp-1s have changed the way my body processes carbohydrates and food more generally. My energy is much more stable. I am so much more in touch with my hunger signals. I have very regular BM’s.

On some level, I feel very weird and ashamed that I am so young and on this drug. But it has been nothing short of life changing for me. Never in my life have I been overweight, but I always hated the way my body looked, and I obsessed over it. Now, this is not an issue for me. I still love going to the gym. I genuinely appreciate my body’s function and look, and I don’t have to white-knuckle my fitness goals anymore. I am working just as hard in the gym. I am eating just as healthily. I have great disciple. But all this isn’t as mentally taxing as it once was. I just don’t have to worry anymore.

I love cooking and I love food. My relationship with food feels so healthy. I still get hungry!

My one complaint is that I have felt periodically anhedonic. I wish I could just have the food-satiety part and not the life-satiety part. Sometimes it makes it hard to stay motivated in other aspects of life. However, I have struggled with intense depression in the past, and I want to draw a distinction between glp-1-induced anhedonia and depression. They are completely different, and I can tell when I’m feeling one vs the other.

Overall: positive, but weird. I have no plans of stopping… let me know what you guys think.

To start off - I have a history of GI issues and I do not have a gallbladder. However my acid reflux has been very controlled for years now! I have diarrhea like once a week but otherwise my GI is best it’s ever been. Also, I am generally very sensitive to medications.

So a few months ago, I tried 2.5 zepbound and omg… SO sick. Explosive diarrhea 4x a day. Reflux so insane and so painful. Gave up on it.

On Monday, 2 days ago, I injected 0.25mg of zepbound. Yesterday was ok except for bad reflux at night and what’s weird is nothing helps. I have a wedge pillow, meds, tums, gaviscon, enzymes, everything.

Then today, I’m still having bad reflux, barely eating and explosive diarrhea 3x already. I just don’t get it. How can this small of a dosage do this to me?

I’m 5’2 and put on a lot of weight due to antidepressants and epilepsy medication. Honestly, diet and exercise doesn’t really do anything for my weight and it’s tough for me to stay on it when I’m having seizures. I’m now 160, hoping to get back down to 135.

I’m just feeling kind of hopeless :( I reached out to my GI dr to discuss. Has anyone had a start like this and then gotten better? Should I go even lower?? Honestly the painful reflux is worse than the diarrhea

Thank you for reading ❤️

I don’t need to loose weight but damn do my joints hurt all the time. I’ve been to doctors and ruled out anything autoimmune.

Anyone out there microdosing solely for the anti-inflammatory effects?
If so, what is your experience?

Hey everyone. I’m ready for some heat and criticism for this, but I really need honest, real-world advice from people who have actually been in this spot.
I know logically that I don’t need Wegovy. I’ve been training hard for years. After a slightly too aggressive bulk, cutting back down has been an absolute nightmare. I’ve leaned out a lot, but I’m just not quite where I want to be yet. My biggest enemy right now isn't discipline in the gym, it’s the relentless "food noise" and cravings holding me back from sticking to the strict deficit needed for that final bit of conditioning.
I’ve been looking into options to quiet that down. I know some people look into Retatrutide for this stage, but honestly, I am way too squeamish about needles to go that route.
Before I make any decisions, I want to hear from anyone who has actually used Wegovy (or similar) when they were already in a good, fit shape, purely for that last bit of stubborn definition!

Is anyone Nanodosing? .05, .025, .01 and below.

I didn’t do well on .05 with Semaglutide having vomiting, diarrhea but did feel the positive effects of no joint aches or pain as I have autoimmune issues.

If you do nanodose, please share how are you get the low doses, needles, etc

Edit: I am indeed talking about Zepbound vials

HYPOTHETICALLY, two people wanting to stay on the same dose and splitting a vial.

I know there are risks of bacteria growth over time because of the lack of preservatives, but what about halving the vial in one sitting, two separate syringes, using alcohol wipes in between?
I ask because it was my PCP that recommended splitting and saving the vial to save money, but I am worried about the bacteria growth I keep hearing about.

I’ve been wondering about something and would genuinely be curious to hear what other people’s experiences have been. Do people who aren’t really overweight, but just want a little extra help losing and maintaining a few pounds, ever use Tirz on a longer-term basis?

I’m especially curious about people who only have a small amount of weight they want to lose. Since they don’t necessarily need to lose a significant amount, do they tend to stay at the lower doses like 2.5 mg or 5 mg, and basically use that as their maintenance dose rather than ever moving up?

I’m wondering if there are people who find that a very low dose is enough for them to gradually lose those last few pounds and then keep the weight off, or if most people eventually need to increase the dose even when they don’t have much weight left to lose. I’d love to hear from anyone who has actually been in this situation and what their experience has been with staying at a low dose over time.

I'm currently microdosing at 1.25mg per week. I see quite a few people here doing shots twice a week or once every five days. I'm just wondering what the reasons for this and what the benefits are?

Male. 5’9”. Fluctuate between 185-195lbs. I’m on week two of GLP-1. I’ve been doing some dives trying to figure out what could or will work best for my goals. (Would love to be back around 160-165lbs) I am active. Not gym wise, but my line of work is very physically demanding and work 12hr shifts while always on my feet with moving and heavy lifting. I’m doing 10 units once a week now. Have noticed appetite suppression. But no real weight loss yet. Which I know won’t happen over night. My main question is, should I be on glp-3 instead of glp-1? And should I be micro dosing? AND, I’ve been researching the wolverine blend, BPC-157/TB-500. From others experience, will that help with muscle and joint pains as much as I’ve read and have heard?

Today marks one year and 17 days since I started microdosing tirzepatide (Mounjaro). I've lost 30 lbs as of today! From 177.6 to 147.6. Over the past year, I've changed nothing about my already healthy diet and didn't increase my exercise.

I started with 0.25 mg once a week and slowly titrated up to 0.6 mg twice a week. I find it helps with pain and inflammation.

I have ME/CFS and unfortunately, live a rather immobile life, so I need a way to lose weight without exercise. I don't think I've lost much muscle over the past year, but without a scan, I can't say.

Anyway, low and slow has worked for me. I'd love to lose another 7.6 lbs, but even if I remain at this weight, I'm happy. My BMI was 27 and now it's 23.8. I went from a women's size 12 to 8. Pretty freaking happy about that. I'm 51, perimenopausal and I have PCOS. So I'm not a straightforward case.

Just wanted to share that microdosing can help you lose weight, if you're patient.

I started on 2.5mg and it was too much for me and I wasn’t able to eat enough to not have major brain fog, mood swings, and felt super sick. My doctor told me to just go off of it because she said the manufacture doesn’t make a product to use less than 2.5mg a dose and she doesn’t support the mircodose.

I see soooo many people only talking about it though. I also have 4 vials left and don’t want to waste them. They are single use vials of 2.5mg. But if I am using a new needle, can I not just draw out 1.25 and then next time. disinfect the top and poke in again drawing up the other 1.25. Am
I missing something? How are other people taking a lower dose?

I was just approved for Tirzepatide at 2.5mg per dosage - one dose weekly. Reading everything I think that's a bit much for my needs and wanted to work my way up to that, if necessary.

I'm that girl who is having the really hard time losing that last 10-15 pounds. I exercise pretty much daily, walk the dog daily, life, yoga - overall really healthy lifestyle. I was thinking about starting with 1 mg and going from there, but I see may people started with far less. Please share your experience, especially if you're in the same situation of needing to lose those last few!

I started tirz in April and hot my goal (well three lbs away). Starting weight was 144 and down to 115. Question is, now what. I started at 1mg, then ended up at 2 mg. I hot 10k steps every day and strength train 5 days a week.

My question is for those that resched their goal, did you trapper off? Do you still microdose? Not sure what to do now.

So I ordered tirz from nexaph and I’ve been trying to do a lot of research. Currently I’m kinda stuck because nexaph provides their testing from janoshik and I can get the COA from the janoshik website too, but the vials they gave me are unlabeled vials which I’m not figuring out are comment and the test come back from April and we are now in march. Do I actually need third party testing because I would prefer to keep my 400 dollars just to test. I’ve been trying to look at local places around me but to no avail. Should I also send my bacteriostatic water for testing to I got it from bacteriostaticwater com
I have my packages so now I’m just waiting to use it or send it back out if I have to

Hi, something I have always wondered: if you lose water weight at first (from any calorie deficit, not just GLP-1 use), wouldn’t it come back after a time? I.e., if you’ve maintained a weight loss for months, why assume that some of it is still “water weight,” assuming you are not avoiding salt?

I know that it’s conventional wisdom that we lose water weight at the beginning of a diet, but why would that stay away, assuming that you’re eating a mix of foods and not just, say, veggies and water-filled fruits, or outright fasting?

Genuine question—please be kind and try not to respond as if I am a moron, even if the answer is obvious to you. Thanks.

Hello, I can’t seem to find any information on this, maybe because it’s taboo to talk about. I’m desperate to improve my sex life as far as pain management goes. I’m going to start microdosing Tirz and wondering if this has helped anyone as far as pain from endometriosis during sex.

I ordered tirzepatide and it came in today! I am wanting to microdose but not sure where to start. For context I’m 5’4 and 145 lbs ish. I just want to recomp mostly (I work out consistently) and maybe lose a few pounds. BUT I really do not like being nauseous, which is great when taking the ultimate nausea-inducing medicine lol. I’ve seen people do anything from 0.2 mg to 1.25 mg starting out and I guess I’m wondering where I should go. Is it worth it to just start at 0.2 and bump it up next week if it goes well? It seems like that dose is so low it may not do anything? I’m happy to take it slow if it means I won’t be miserable.