u/Jaded-Part4151

4 years of severe long COVID/MCAS with mostly neurological and cognitive symptoms plus significant food and environmental reactivity. Extremely medication sensitive. Have tried ketotifen, cromolyn, and famotidine, all with bad reactions even at low doses, though I may not have gone slow enough.

Looking for recommendations on the most tolerated first medication, ideally something that calms overall mast cell reactivity and helps with brain fog, so other treatments can actually work. What worked for you when you were highly reactive and just starting out? I am between trying cromolyn or ketotifen again, just slower, or experimenting with something like Allegra

I've been taking .25 for close to a week now after titrating from 1/8 for a few days. I'm feeling very depressed, flat, anxious, more brain foggy, every dose. I am very sensitive to medication. I don't feel like I have many other options and have been suffering for years so i'm willing to stick with it for a bit longer. But wondering if anyone experienced what i'm going through and if it got better.

I just turned 23 and have been dealing with POIS in combination with severe ME/CFS (Long Covid), MCAS, and dysautonomia for 4 years now. Relapsing with orgasm has by far been my biggest triggers, setting me back each time, and not allowing me to pursue treatments for my health. Yet im having trouble abstaining. Looking for someone to do consistent check ins with, someone whos serious about abstaining. I don't mind sharing possible treatment information too.