u/LoordKira

I suffer from Depression, Obsessive Traits (possibly OCD), lack of motivation, I can't get out of bed recently without having massive anxiety. This is destroying everything in my life at an unprecedented rate, my relationship, business, mood, I'm at one of my lowest if not lowest point.

I have currently just started taking Sertraline 100mg for about a week.

I was already on Sertraline for about 3 months back at the beginning of 2026 and I was doing better but suffering from the classic SSRI side effects, I tapered it off, added Trazodone and went Hypomanic according to my Doctor, so we dropped it completely and he prescribed me Trazodone 300mg and Olanzapine 5mg, useless to say that this combination completely turned me off, I was sleeping all day. Then they changed my Psychiatrist and the new one diagnosed a mixed state and decided to prescribe me Aripiprazole, took it for 16 days and I'm out of that hell. Worst experience of my Life. Now I'm on Quetiapine 100mg at night to help with sleep and 100mg of Sertraline, but I'm looking forward to add Wellbutrin to it. Has anyone been on this combination? “Welloft”? How did it work for you? I'm scared to take Wellbutrin alone for my Obsessive mind and my Anxiety.

So yeah, how did it go, how long were you on Sertraline before adding Bupropion? Did it help with the ADHD - like symptoms, Depression, was anxiety manageable? Just hearing anything positive would help.

My Doctor didn't even know this combination was possible until I suggested it which completely killed my trust in him... but we'll see. Currently I can't add Wellbutrin yet, the first week on Sertraline has been tough enough already.

I apologise in advance if I make mistakes related to this theme as English isn't my first language and I rarely talk about this stuff in English.

I've started my journey with Pharmacology almost 8 months ago now, first I took Sertraline, maxed at 150mg, then we dropped it because it apparently gave me a bit of hypomania (I still disagree with that, I was active for the first time in my life, maybe too active, maybe I just needed a little of some mood stabilizer). My diagnosis? I don't know, mixed state of depression and maniac episodes, anguish and severe anxiety, I do have Obsessive Traits, in my opinion I am OCD with my main focus being morality and my relationship with my GF, I likely have ADHD too but still waiting for the diagnosis as in my country being ADHD isn't that important or limiting so the waiting list is... eternal.

Anyway, after Sertraline I went on Olanzapine 5mg and Trazodone Hydrochloride maxed at 300mg. It was living hell. I had no motivation, no desire, every task felt like climbing a mountain, getting up from bad, meeting with someone and this absence of desire and feeling is and has completely destroyed my relationship. After that, they changed Psychiatrist because the previous one left, I hope they would change for the better but... I couldn't know the living hell I was going to go through, he gave me Aripiprazole 10mg then he said why not let's do 15mg, this hell lasted only 2 weeks now I'm off of it... he gave me Aripiprazole as monotherapy because he said the drug interacts with your Dopamine receptors giving a stable but not too high boost of energy and motivation and also interacts with a Serotonin receptor to help with the anguish that the OCD creates.

I swear, I've never felt less unmotivated and more trapped in my bed than ever, I couldn't even force myself to watch a show or scroll on YouTube, my Screen on Time has probably never been lower because it just felt (and still feels) painful to focus on anything. Sometimes I wish I never started Pharmacotherapy at all.

This brings me to my question, I read extensively online, and for OCD there's little to do but use SSRI and I want my Doctor to prescribe me SSRI (maybe Sertraline / Zoloft) again, the problem with this was I had ejaculation issues, emotional blunting and a very hard time focusing, so I had already requested my previous Doctor to tackle this issues WITHOUT REMOVING the Sertraline, I thought my solution could've been Bupropion. Do you know if it's a combination possibility? To treat perhaps my low Dopamine baseline due to my ADHD with NDRI, and to treat my OCD symptoms with SSRI.

Currently I'm on Quetiapine (low dosage 25 - 75mg depending on my needs) and Benzodiazepines like Xanax or Lorazepam, he gave me this not as a Therapy I HOPE because none of this helps me with motivation / or the stickiness of my Obsessions. I just don't even know anymore what my problems are, there have bene so many different kind of Therapies that I don't even know what I'm supposed to be curing anymore. I feel like my life is slipping away, I'm going to be financially ruined if I continue like this and my only hope is that the Doctor understands the right Therapy, I know getting the perfect Therapy is impossible, but I need Energy with clean Dopamine, cure the Anxiety, Anhedonia, focus and cure my OCD. I don't feel like my Doctor is even able to do so, he seems fresh out of College but sadly I can't change him however I want, I am with the National Healthcare System, there are not many Doctors and they assign you with one and you with him, sometimes I find myself describing him the right Therapy I may need... I just don't know anymore. In 8 days I have a work schedule coming up, and from then I'll have more and more and currently I'm just on fucking sedatives... this gives me even more Anxiety the fact that I don't know what to operate, to be a function and functioning Human Being. How can he not understand it.