u/Low_Implement6590

Hello!
I recently posted about how I’m making a lot of blast with high grades, but I’m getting no euploids. I just spoke with my doctor and they said in their entire career they have never seen a patient that makes such high number of good grade blasts for my age (41.5) but no euploids. I’ve made 15 so far and zero euploids (2 rounds).
They are perplexed and have reached out to other colleagues that have also been equally as stumped. They think silent endometriosis but then I’m making good blasts so that may not be it. They also suggested karotype but there is no pattern in my abnormalities.

They are going to completely re do my protocol and basically Lower my meds to try to produce less eggs but hopefully better quality.

They are also switching genetic screening labs to one that can tell if the issues are from the maternal or paternal side.

They think it’s wild I haven’t even got a mosaic it’s just all completely random abnormalities with many having only one abnormality.

They are pretty much going to try it all. I asked about donor eggs but they said not yet, since I’m making so many blasts.

My friend who also is an RE also said she has never seen so many abnormal embryos in her entire career. I guess I’m just special?

Has anyone else had a similar experience to mine?

Protocol is:
Luteal phase priming with estrace, testosterone gel, omnitrope for 12-14 days

Stims: 150 menopur, 225 gonal F, omnitrope, ganirelix last 4-5 days, stim for 10-11 days and trigger shot is pregnly 10000 with 450 iu gonal F boost

Both times that’s been my protocol
Also have male factor DFI 34% and 2% morphology used ICSI and zymot last round

First round: 10 eggs retrieved, 7 blasts
Second round: 12 eggs retrieved, 8 blasts
AMH: .531 DOR
12 follicles each round

Taking truniagen and ubiquinol 600mg daily and prenatals. No alcohol only one cup of green tea per day and I’m at low weight and have a very clean and active lifestyle.

Hello! I just got my PGTA after my second egg retrieval and have had 0 euploids from 15 high grade blasts. Age 41.5. I know I’m on the wrong side of statistics but just curious how many cycles on average women have done at my age and gotten a euploid. Also, did you do any protocol changes that you felt made a difference in getting a euploid? Thank you!

I just got my genetic results back from my third round and out of 8 blasts I got 0 euploids. I’m 41.5 turning 42 in October. I’m just at a loss right now. My first ER was botched and I got one blast. I switched clinics and then got 6 blasts the second round and 8 blasts the third round (total of 15 blasts)- but have yet to produce a euploid. I started egg retrievals when I just turned 41.

I really don’t know what else to do and if I should even keep trying. I’m on 600mg ubiquinol daily, have a super clean diet, good weight, basically doing all the “right things” and it doesn’t seem
To even matter. My RE is really hopeful and basically counts this as my second round. She wants me to keep going but I think emotionally I’m done.

Do I try for a 4th round (my doctor said technically it’s like my 3rd round because my first one had such a poor protocol)?
I’m just losing all hope and really feel like giving up.
Has anyone almost given up and then kept going and got good news?? I just feel like it’s never going to happen for us.

Hello! I got an email that my PGTA results were ready today from Igenomix. I called my clinic to ask about them and they said the doctor will follow up and then they never called me. Is this a bad sign?

Hello! I’m 41.5 (turning 42 in October). I recently did two ER back to back (one in March and the next one in April). My first retrieval yielded 9 eggs, 6 turned into blasts grades 4bc 4ab 4bb 3bb 4ac 4ba. We PGTA tested and got 0 euploids, our highest grade embryos had the least amount it abnormalities (2 only had one chromosomal error and another had a partial). I was so discouraged because we had 6 embryos and my RE really thought we may get at least one Euploid.
We tested my husbands sperm DNA after that first round and found that it was very high DFI, 35% DFI.
We only used ICSI first round and then added Zymot for the second because of high DNA errors in his sperm.
Second round ER yielded 12 eggs, 10 fertilized, 8 turned into blasts grades

1. 4ab
2. 4aa
3. 4ab
4. 4aa
5. 4ab
6. 4aa
7. 4bc
8. Arrested
9. Arrested
10. 4ab

I thought our first retrieval had pretty decent grade embryos but after the second round I realized they were good to fair.
My question is for those of you that DNA tested and got euploids, did you see a correlation between better graded embryos turning into euploid embryos? Or was it completely random and “C graded” embryos produced euploids and “A graded” embryos produced aneuploids?

I’m reading mixed data on the internet and I’m just curious what people have experienced.
We should be getting our results back next week but the waiting is so hard, even though I’m expecting 0 euploids again. Mentally I’m prepared to do a 3rd round.