Well Researched X Post on GH Daily v EOD
A well researched article on this topic. They concluded EOD is better than Daily.
Does the same apply in longevity or for supra physiological levels?
u/ManusPHConsults — 1 day ago
▲ 1 r/fitness50plus
Thymus Regeneration
GH and Thymus Regeneration
Something that I never really see get discussed is Thymus Regeneration from the use of exogenous GH.
By 50 the Thymus is basically gone. Exogenous GH shows thymic mass increasing along with density and increased T cells.
High IGF1 levels in animals do correlate with reduced longevity. Not as strong in human studies and the levels needed to reduce longevity do seem to be supra physiological.
The lack of Thymus mass in over 50s is a reason given for the reduced ability to fight off disease and cancers. High IGF1 could be cancer promoting.
Initial skim of research would say GH bad for.longevity based on animal studies. But when you look deeper, it's a U shaped curve, too low and too high IGF1 can be the problem. And the too high does seem to be at acromegaly levels.
My reading is that low dose GH is more beneficial than not. Especially if hormone replacement therapy has your hormones sorted.
Love to.hear discussion from people.smartet than me.
Note I'm not advocating people use GH unless prescribed by a doctor. I think it's an interesting discussion.
u/ManusPHConsults — 23 days ago
▲ 5 r/Aging
Thymus Regeneration and Longevity
GH and Thymus Regeneration
Something that I never really see get discussed is Thymus Regeneration from the use of exogenous GH.
By 50 the Thymus is basically gone. Exogenous GH shows thymic mass increasing along with density and increased T cells.
High IGF1 levels in animals do correlate with reduced longevity. Not as strong in human studies and the levels needed to reduce longevity do seem to be supra physiological.
The lack of Thymus mass in over 50s is a reason given for the reduced ability to fight off disease and cancers. High IGF1 could be cancer promoting.
Initial skim of research would say GH bad for.longevity based on animal studies. But when you look deeper, it's a U shaped curve, too low and too high IGF1 can be the problem. And the too high does seem to be at acromegaly levels.
My reading is that low dose GH is more beneficial than not. Especially if hormone replacement therapy has your hormones sorted.
Love to.hear discussion from people.smartet than me.
u/ManusPHConsults — 23 days ago
▲ 3 r/BodyHackGuide
GH and Thymus Regeneration
Something that I never really see get discussed is Thymus Regeneration from the use of exogenous GH.
By 50 the Thymus is basically gone. Exogenous GH shows thymic mass increasing along with density and increased T cells.
High IGF1 levels in animals do correlate with reduced longevity. Not as strong in human studies and the levels needed to reduce longevity do seem to be supra physiological.
The lack of Thymus mass in over 50s is a reason given for the reduced ability to fight off disease and cancers. High IGF1 could be cancer promoting.
Initial skim of research would say GH bad for.longevity based on animal studies. But when you look deeper, it's a U shaped curve, too low and too high IGF1 can be the problem. And the too high does seem to be at acromegaly levels.
My reading is that low dose GH is more beneficial than not. Especially if hormone replacement therapy has your hormones sorted.
Love to.hear discussion from people.smartet than me.
u/ManusPHConsults — 23 days ago
Split Dosing. Graph showing 1v2v3 x week on something with 6 day half life
Not advising. This is for discussion and educational purposes.
Many of the studies of popular research supplements at the moment do a once per week injection protocol.
But this can be done to maximize compliance. Eg the belief that once per week injection is more likely to be done than if it is multiple. Or for other reasons too. Eg with a glp 1 some people might like to get hungrier at the end of the week.
It takes 4-5 half lives to reach a steady state. For a weekly dose, the 2nd dose even with a 6 day half life still adds more on top of the previous dose. Whether you split dose or once weekly dose the average concentration will be the same once you reach steady state.
But the peaks and troughs are smoother. Which could be a good thing or a bad thing depending on the compound.
The difference between 2x weekly and 3x weekly is significantly less for a 6 day half life than 1x weekly and 2 x weekly.
If you look at the glps for example, eg Sema, Tirz and Reta. A lot of people report nausea or other GI issues around injection day. And that the hunger suppression wears off as you get near to next week's injection.
For.many it is not the days around injection day that they have an issue with hunger, it is the day(s) before the next one. Which is due to the lower levels (trough) occuring the further away you get from the last injection.
For those people a split dosing schedule can lead to.lower total weekly doses as it's the tough that is the issue not the peak.
For people who are more sensitive to nausea or GI issues, split dosing can reduce or eliminate those side effects as the peak is lower.
Some people perfectly cope with being hungrier a few days per week. Some want to enjoy a larger family dinner on a Sunday so I'm either case once per week can work too.
Just because the trials or the clinical guidance says one thing it doesn't mean it is right for all or the most effective.
Testosterone replacement therapy is a great example. Standard protocols used to be a 250mg shot ( or higher) once per month, later moving to fortnightly. In Australia testosterone even comes in preloaded 1ml 250mg syringes. The peaks and troughs on those schedules are brutal. High estrogen side effects around the injection and very low testosterone before the next is due. (Test ethenate has a half life of 4-5 days.)
Modern clinics have moved to 2 or 3x weekly injections of usually 100-150mg.
There can be many reasons why clinical guidance and studies prescribe a certain dosing schedule. They may or may not be optimal.
3x weekly for both TRT and GLPs are my preference. For competitive bodybuilders using supra physiological doses, daily or every other day dosing can greatly reduce the negative side effects
(of which there are many. They are often taking in the grams rather than mg and adding anabolic steroids on top of their supra doses of testosterone.)
u/ManusPHConsults — 28 days ago
▲ 3 r/BodyHackGuide
Why GLPs Can Feel Better for Males v Females
After a discussion with a couple of cohabiting lab rats today thought it would be useful to post.
Body fat reduction reduces the aromatase enzymes, so it reduces the conversion of testosterone to estrogen.
So in guys they have higher total testosterone from the fat loss.
Also can decrease SHBG and thereby increase the percentage of total testosterone to free testosterone.
Testosterone is not just a muscle hormone, it affects well-being, mood, drive, energy levels etc.
u/ManusPHConsults — 1 month ago