u/ModusOperandi39

My father was diagnosed almost 2 years ago with Stage IV lung adenocarcinoma (NSCLC) with bone metastases.

At diagnosis which was in June 2024, a liquid biopsy (blood test) that only tested for EGFR mutations came back positive (EGFR L861Q).

A few months later, the tissue biopsy molecular testing showed EGFR wild-type, but identified a KRAS G12C mutation instead.

He was initially treated with osimertinib + chemo for a year although progression started sooner than the one year mark, and later in October 2025 switched to sotorasib after KRAS G12C was confirmed. Sotorasib controlled the disease for about 4–5 months, but he has now developed disease progression.

We are currently waiting for the results of a new comprehensive NGS test to better understand the resistance mechanism.

Has anyone experienced something similar?

EGFR detected on liquid biopsy but EGFR wild-type on tissue biopsy?

Both EGFR and KRAS G12C detected at different times?

What did your repeat NGS show after progression?

What treatment worked next?

My father was diagnosed almost 2 years ago with Stage IV lung adenocarcinoma (NSCLC) with bone metastases.

At diagnosis which was in June 2024, a liquid biopsy (blood test) that only tested for EGFR mutations came back positive (EGFR L861Q).

A few months later, the tissue biopsy molecular testing showed EGFR wild-type, but identified a KRAS G12C mutation instead.

He was initially treated with osimertinib + chemo for a year although progression started sooner than the one year mark, and later in October 2025 switched to sotorasib after KRAS G12C was confirmed. Sotorasib controlled the disease for about 4–5 months, but he has now developed disease progression.

We are currently waiting for the results of a new comprehensive NGS test to better understand the resistance mechanism.

Has anyone experienced something similar?

EGFR detected on liquid biopsy but EGFR wild-type on tissue biopsy?

Both EGFR and KRAS G12C detected at different times?

What did your repeat NGS show after progression?

What treatment worked next?

I'd really appreciate hearing from anyone with a similar experience. Thank you!

Should I continue taking Sotorasib (Lumykras) while receiving 10 sessions of thoracic radiotherapy, or should I stop it during treatment?

Sotorasib kept the cancer under control for about 4 months (confirmed by CT scans), but the disease has now progressed. I'm having radiotherapy as a bridge treatment while waiting for the results of a new NGS test, which should be available in about two weeks.

I'm mainly concerned about whether continuing Sotorasib during radiotherapy is beneficial or if it could increase toxicity without providing much benefit.

Has anyone been in a similar situation, or have any oncologists here managed patients like this?

Should I continue taking Sotorasib (Lumykras) while receiving 10 sessions of thoracic radiotherapy, or should I stop it during treatment?

Sotorasib kept the cancer under control for about 4 months (confirmed by CT scans), but the disease has now progressed. I'm having radiotherapy as a bridge treatment while waiting for the results of a new NGS test, which should be available in about two weeks.

I'm mainly concerned about whether continuing Sotorasib during radiotherapy is beneficial or if it could increase toxicity without providing much benefit.

Has anyone been in a similar situation, or have any oncologists here managed patients like this?

Hey. I am living in Europe. Is it possible for me to go to a clinical trial in another european (or not european) country ? If so, do i have to pay for something besides transportation, food and a place to sleep ?

Hey. I am living in Europe. Is it possible for me to go to a clinical trial in another european (or not european) country ? If so, do i have to pay for something besides transportation, food and a place to sleep ?

Hello. I live in Europe. My father has stage 4 non-small cell lung cancer. He is on line 3 of treatment. I don't know if I can access clinical trials outside my country. If possible, please tell me how. I would also like to know if I can pay to have access to clinical trials that he would normally not be allowed to participate in (e.g. line 1-2 trials)

Hello. I live in Europe. My father has stage 4 non-small cell lung cancer. He is on line 3 of treatment. I don't know if I can access clinical trials outside my country. If possible, please tell me how. I would also like to know if I can pay to have access to clinical trials that he would normally not be allowed to participate in (e.g. line 1-2 trials)

Buna. O sa intru direct in subiect. Am aproape 30 ani, fara frati/surori sau legatura apropiata cu alte rude. Cand aveam 10-11, am pierdut o pe mama. Iar acum o sa l pierd pe tatal meu. As vrea ca prin aceasta postare sa apuc sa vorbesc cu oameni care trec in prezent sau au trecut relativ curand prin asa ceva. Ma simt izolat si as vrea sa pot vorbi cu cineva care chiar ma intelege

Vreau sugestii de modele/branduri ochelari autoreglabili cu plaja cat mai mare (macar 0.5-3). Daca puteti da link e super

Va rog sa mi dati recomandari de saltea anti escara cu compresor. Caut ceva de calitate superiora, sa fie cat de siletioasa se poate. Pretul nu e relevant

Va rog sa mi dati recomandari de saltea anti escara cu compresor. Caut ceva de calitate superiora, sa fie cat de siletioasa se poate. Pretul nu e relevant

Va rog sa mi dati recomandari de saltea anti escara cu compresor. Caut ceva de calitate superiora, sa fie cat de siletioasa se poate. Pretul nu e relevant

Hey. Is adagrasib a good option for people who were put on sotorasib and had limited response (limited in time not results, we re talking about a couple of months, 4-5). Is there any other optionin case the patient doesnt show other mutation types in the NGS tests ? Maybe immunotherapy ? Or a clinical study like that

For those of you with direct experience in oncology clinical trials, I would really appreciate your input. In the context of stage 4 non small cell lung cancer. The patient has a KRAS G12C mutation or had it anyway. He was put on sotorasib for the past half a year and now the cancer began to grow again. He also has bone metastasis and one small stable metastasis his liver. What would you generally recommend or prefer between:

​

- a clinical trial involving an antibody-drug conjugate (ADC) approach. In refering to the clinical trial called: TUB-030

​

OR

​

- a clinical trial based on immunotherapy (for example PD-1 inhibitors or combinations like cemiplimab-based regimens). The name of the possible trial is: THIO + cemiplimab versus standard of care . Problem here is that its a 50-50 change if you get to test the new drugs or they put you on the classic chemotherapy

​

For those of you with direct experience in oncology clinical trials, I would really appreciate your input. In the context of stage 4 non small cell lung cancer. The patient has a KRAS G12C mutation or had it anyway. He was put on sotorasib for the past half a year and now the cancer began to grow again. He also has bone metastasis and one small stable metastasis his liver. What would you generally recommend or prefer between:

​

- a clinical trial involving an antibody-drug conjugate (ADC) approach. In refering to the clinical trial called: TUB-030

​

OR

​

- a clinical trial based on immunotherapy (for example PD-1 inhibitors or combinations like cemiplimab-based regimens). The name of the possible trial is: THIO + cemiplimab versus standard of care . Problem here is that its a 50-50 change if you get to test the new drugs or they put you on the classic chemotherapy

​

Stiti cumva companii care desfasoara studii clinice pe parte oncologica ?

Stiti cumva companii care desfasoara studii clinice oncologice ?

Am avut deja massage gun. Acum as vrea un aparat de masaj (nu fotoliu) care sa fie hands free si sa inita cat se poate de bine masajul uman. Preferabil ceva care poate fi folosit pt ceafa, upper back, lower back. Am vazut sugestii pe tiktok dar pareau sponsorizate sincer

Am avut deja massage gun. Acum as vrea un aparat de masaj (nu fotoliu) care sa fie hands free si sa inita cat se poate de bine masajul uman. Preferabil ceva care poate fi folosit pt ceafa, upper back, lower back. Am vazut sugestii pe tiktok dar pareau sponsorizate sincer