had time this weekend so reconstituted two vials back to back. both stored in the fridge now. anything different about storage or shelf life when you do multiple at once versus one at a time
Kaj menite o novem ministru? Se kaj premika?
Is anyone else experiencing this? I've seen people talk about carbonation causing burps but not the heavy, bloated sensation. Just curious if I'm alone on this one.
I am 19 and my starting weight was 156 pounds. I am currently taking the weight loss shot, but I am still hungry. My mom also has me on a strict keto diet, so I only eat carbs one day out of the week.
I lost 25 pounds in the first month, but I am already starting to get tired of this. Does this process constantly feel like a chore? I am just tired of only being able to drink protein shakes every single day.
wasn't expecting this to become part of my job. I don't know exactly what to tell them. I use it myself but professionally I'm not sure where the line is or whether or not I can recommend them. anyone else in fitness or health adjacent work navigating this? Are there any laws corresponding to this? I also will not be “supplying” or “hooking them up” if anyone else is asking.
I'm 6 months into Zepbound and I've noticed something weird. I can be genuinely hungry, like I haven't eaten in 6 hours and I know I need food, but my stomach doesn't make any noise. No growling, no rumbling, nothing. It used to sound like a dying whale when I got hungry. Now it's just... silence. Is this the delayed gastric emptying? Does the medication just slow everything down so much that the stomach doesn't contract the same way?
currently doing 400mg of test cyp a week. im pinning twice a week. i want to switch to test prop for the last few weeks of this cycle to clear out some water weight. since cyp stays in your system for so long what is the easiest way to switch over? do i just stop the cyp right away and start pinning prop every day or do i need to lower the cyp slowly while adding the short ester in. just looking for the standard way people do this so my levels do not spike like crazy.
Zanima me, koliko ste stari in koliko dopusta imate? Iz firbca.
happening maybe twice a week now. middle of the night, calf completely seizes up. never had this before. been on reta about six weeks. potassium maybe? already doing electrolytes but maybe not enough
A phase 2b trial for aleniglipron, another oral small-molecule GLP-1 receptor agonist, was published recently. It's in development for obesity treatment and represents another entry in the growing field of non-peptide oral GLP-1s.
The advantage of these small-molecule drugs is that they're resistant to enzymatic degradation, which means they can be taken orally without the strict fasting requirements of peptide-based oral drugs like Rybelsus. They're also cheaper to manufacture at scale, which could eventually translate to lower prices. It's still early days (phase 2b), so we're a few years away from seeing this on pharmacy shelves. But the sheer number of oral options in development tells me that the needle-free future is coming faster than I expected.
I have been working in a pharmacy for ten years, and I have never had to deal with a group of patients quite like this. People have been getting really upset with us lately because of the GLP-1 shortages, especially with Mounjaro and Zepbound. I had someone last week tell me it was my personal fault for filling their script when I knew it would be on backorder. I do not even write the prescriptions. I have had people yell at me because their medication is out of stock, and others cry saying they need the drug and that we do not understand. I get the frustration, but we really cannot control the supply chain. Dealing with the constant complaints and blame over these weight loss medications is just getting exhausting. Why are these specific patients so hard to deal with right now?
so for context I have had a needle phobia my entire life. not like "oh needles aren't fun" I mean full avoidance, cancelled blood draws, looked away during every vaccine since I was eight years old. been sitting on my reta kit for three weeks working up to it after my friend convinced me to get into it
Well……. did it twenty minutes ago.
sitting on my bathroom floor right now actually. felt nothing. NOTHING. three weeks of talking myself into this and it was completely unremarkable. I don't know whether to laugh or be annoyed at myself for waiting so long
A 2026 analysis of the SELECT trial, which followed over 17,000 patients with heart disease and obesity for an average of 3.3 years, found that those taking semaglutide had a 29% lower risk of dieing from an infectious cause compared to those on placebo. The drug didn't just lower risk for one type of illness; its effect was seen across both cardiovascular and non-cardiovascular causes of death, including fewer deaths from serious infections and COVID-19-related issues. The benefit was most pronounced in non-cardiovascular death, with fewer deaths due to severe infection in the semaglutide group.
I have a decent amount of tissue built up under both sides from my previous cycles. I am looking at getting the surgery to just have it removed because it is really noticeable through thin shirts now. The problem is the cost. It is a massive expense to pay out of pocket. I also know for a fact I am going to run more gear in the future. I plan to keep lifting and cycling for a long time. Is there any actual point in spending thousands of dollars to cut the tissue out if I am just going to risk it coming right back on my next blast?
I hear some guys say the surgeons remove the entire gland so it can never grow back, but others say that is fake and you can definitely get it again if you mess up your estrogen control later on. Did you have any issues with it returning or are you completely clear now?
We were at a birthday party and I was pushing a slice of pizza around my plate. My daughter looked at me and said, "Mommy, why don't you like food anymore? You used to love pizza." I froze. I didn't want to say "the medication makes me not hungry" because that's a lot for a kid. I didn't want to lie either. I just said "I'm full sweetie" and changed the subject. It broke my heart a little. For parents on these meds, how do you explain your changing eating habits to young kids without confusing them or projecting your own food issues?
genuinely curious what the collective wisdom of this sub adds up to
Novo Nordisk has officially submitted CagriSema (semaglutide + cagrilintide) to the FDA. This is the first major combo drug targeting two different hunger pathways: GLP-1 and Amylin. Amylin is a hormone we secrete with insulin that tells our brain 'that's enough food.'
In the REDEFINE 4 head-to-head trial against Zepbound, CagriSema achieved 23% weight loss. While this narrowly missed beating the market leader Zepbound (which hit 25.5% in adherent patients), 23% is still a massive clinical achievement. The combo drug could be a powerful tool for patients who have hit a frustrating plateau on standard GLP-1s. An FDA decision is expected by late 2026, with a launch early in 2027
genuinely confused because the rest of my body is clearly changing but my stomach makes me look like I am 4 months pgrengnant and sometimes looks even worse. not sure if this is a side effect thing or just how fat loss works in that area or something else entirely. anyone dealt with this? I’m becoming paranoid
We've been married 15 years. He's always been the "fit one", naturally thin, never struggles with weight. I've lost 60lbs on Wegovy. Last night he admitted that he feels threatened. He said "you're becoming a different person and I don't know if I fit into your new life." I was stunned. I'm not leaving him. I'm not judging him. I just want to be healthy. Has anyone else's partner felt insecure about their weight loss? How do you reassure someone without downplaying your own success?
I see so many people in these groups switching over to Retatrutide right now and it is wild to me. The weight loss numbers in the trials look great, but we still do not have the long term safety data for it. People are ordering it from overseas vendors and taking it just because they want to lose weight faster than they did on Tirzepatide. I get the appeal of a triple agonist, but risking your health on something that is not fully approved yet seems like a bad idea. It feels like people are ignoring the potential risks just because the fast results are so tempting. Are you guys really willing to take the unknown risks just to speed up the process, or do you just assume it is completely safe because the other medications are?