Killing Tempo
Tempo (BS, pg. 122) has the injection and ingestion vectors. It imposes -1 Willpower on the subject, and gives them the Astral Perception power. But most people don't have the Astral skill, and so will be unlikely to get much use out of it.
Tempo is a remarkable assassination tool. Dose the victim, then have an astrally projecting magician kill them with Manabolt while the victim's Willpower is down by one, and before the victim can possibly figure out what is happening.
Except...the description of this Awakened drug says that it gives the user Astral Perception. Does this mean that they automatically perceive astrally, whether they want to or not? A character who has Astral Perception due to having a Magic attribute can turn it on and off.