Day 17 on Lithium – Encouraged by some changes, but scared by the ups and downs.

Hi everyone,
I’m looking for some reassurance from people who have actually been through the first few weeks on lithium.
I’ve been taking lithium for about 17 days (currently around 1150 mg, therapeutic blood level around 0.5–0.6, recently increased slightly). I’m also taking quetiapine.
The last few months have been incredibly difficult with severe anxiety, depression and a lot of despair. My biggest wish is simply to get back to being a present father for my two daughters.
The confusing part is this:
A few days ago I had what was probably my best day in weeks. I made it through my first day back at work after three weeks of sick leave, spoke in a meeting with more than 30 people, even went to the gym, and in the evening I genuinely felt hopeful. It was an “orange day” in my mood tracker (a really good day for me).
Then today I had another dip.
Not a complete crash, but more anxiety, some derealization, sadness and the familiar fear:
“What if lithium isn’t working after all?”
At the same time, when I look at the bigger picture, I also notice some positive changes:
I haven’t had the same overwhelming despair that I had before starting lithium.
My emotions seem to be changing. Instead of constant panic, I’m actually grieving my divorce and missing my family, which somehow feels painful but more “real.”
I’ve even had brief moments where I genuinely felt connected to my children again.
I seem to be functioning a little better overall, even if I still have difficult waves.
So my question is:
Did anyone else experience these kinds of waves during the first few weeks of lithium?
Did you have good days followed by disappointing dips before things gradually became more stable?
I’m not looking for false reassurance—I know everyone is different. I’d just really like to hear real experiences from people who remember what the beginning was like.
Thank you. I really appreciate this community.

reddit.com
u/Pure_Journalist8845 — 6 days ago

How long did it take before you started to see improvement using Lithium as an augmentation?

Hi everyone,
I just started Lithium (Lithium Carbonate / Quilonum Retard) today as an augmentation to my antidepressants (currently also taking quetiapine and escitalopram) for treatment-resistant anxiety and depression.
I’m curious about your experiences:
How long did it take before you noticed the first improvements?
What was the first thing that got better (anxiety, mood, sleep, emotional stability, etc.)?
Did it help you feel more like yourself again?
Were the first couple of weeks difficult before things improved?
I’ve been struggling for a long time and I’m really hoping this combination can help me finally get out of this anxiety/depression spiral and be present for my kids again.
I’d really appreciate hearing your real-life experiences!
Thank you ❤️

reddit.com
u/Pure_Journalist8845 — 24 days ago

Seroquel dose increase

Hi all, I need some reassurance: I have increased my dose of Quetiapine (in accordance with my psychiatrist) from 100mg to 300mg. It’s day one so probably difficult to judge if the new dose is working (augmentation for anxiety and depression). I feel quite restless today. Will this settle over time? What are your experiences? Thanks for sharing! ❤️

reddit.com
u/Pure_Journalist8845 — 26 days ago

Abilify, felt better at first, now feeling worse

Hey everyone,
I’m wondering if anyone else had a similar experience with Abilify (aripiprazole).
About a month ago I increased my dose and after an initial “honeymoon phase” I suddenly became extremely internally restless, anxious and kind of disconnected/derealized. It felt like my nervous system was constantly vibrating. I eventually reduced the dose again and things improved quite a bit.
A few weeks later I tried a low dose again (2.5–5 mg range). At first it actually seemed to help:
more motivation

more connected to my kids

more hopeful

more stable days

But now after around 1–2 weeks I suddenly feel very similar again:
inner restlessness

anxiety without a clear trigger

feeling “not grounded”

tired and agitated at the same time

weird dysphoric feeling / pit in stomach

slight derealization

What confuses me is:
How can something seem to work well at first and then almost flip into the opposite?
Has anyone experienced:
delayed akathisia?

subtle/internal akathisia?

activation that only appeared after days/weeks?

improvement again after stopping or lowering the dose?

Would really appreciate hearing similar experiences because right now I feel pretty confused and discouraged.
Thanks 🙏

reddit.com
u/Pure_Journalist8845 — 1 month ago