u/Redify_Aeiou

Am I an SHBG mutant or is this a result of using pills?

9 months HRT

I take a 2 mg pill at morning and 2 2 mg pills at night as well as 6.25mg CPA every two days

My E is at 154 pg/ml and T (free and total), LH, FSH basically zero

SHBG was 124 nmol/l

Progress more or less stalled for 5 months until I reduced the CPA dosage to every two days instead of every day

Planning on switching to patches due to first pass effect plus more consistent levels (If anyone knows whether Sandoz or Estradot is better I appreciate any experiences)

Will also try Boron and letting my T increase a little somehow, afaik CPA halflife is around 40 hours so I am not sure about once every 3 days, I also cannot cut it into more than 4 pieces

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u/Redify_Aeiou — 2 days ago

Why do we care so much about SHBG if the T and E will eventually just get released and enter the cells anyways?

I thought I more or less understood SHBG until I read this quote from the DHT backdoor Wiki page:

"Sex hormone-binding globulin (SHBH) transports the majority of circulating T to the cells of androgen target tissues, where it is then 5α-reduced to DHT."

Why does T not get transported in Albumin for example? I know the SHBG - Testosterone affinity is high but that should also technically make it a worse carrier for it as it's harder to diffuse into the cell

u/Redify_Aeiou — 3 days ago

If sequencing companies are so dubious, why are they so recommended?

I understand that for us we are following more direct gene associations relating to our transition, as opposed to the techbro longevity BS most people look for, but with the amount of false positives/negatives I've been hearing about, how useful is it really?

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u/Redify_Aeiou — 4 days ago

Intermittent jaundice/anemia

Happened to me for the first 4 months of HRT or so, then just went away

I would just go about my day when suddenly I would notice I'm really yellow, or someone would point out I look like a ghost, only lasted for a couple minutes at a time tho

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u/Redify_Aeiou — 10 days ago