u/Specchio_Cycling

Hi everyone,

I wanted to share my LDN experience and titration so far in case it’s helpful to others, and to hear from people who’ve been in a similar place.

Background:
I have ME/CFS. Started LDN in mid-June 2026.

Titration timeline:

• Mid-June: Started at 1.5 mg in the morning
• July 2: Increased to 2 mg (switched to bedtime)
• July 23–24: Increased to 3 mg total — 1.5 mg morning + 1.5 mg night

I’ve now been on the 3 mg split dose for about 3–3.5 weeks.

Current effects:

• Positive: Feeling a bit more motivated and slightly more energized. Overall I think it’s helped both my energy level and mood.
• Pacing: I still use the Visible app and try hard not to exceed my points. I can still feel when I’ve overdone it. I’m not completely sure if I’ve had true PEM because I’ve been very careful about avoiding excess exertion.
• Side effects:
  • If I take the 1.5 mg nighttime dose too early, I get pretty fidgety and it makes falling asleep harder.
  • Either dose can make me nauseous if I don’t take it with food.

I’m starting to feel like I may be near my optimal dose, or possibly a little over it — though that’s just a guess at this point.

Would love to hear from others who’ve used a morning/night split, especially around the 3 mg range, or who dealt with fidgetiness/sleep issues from the nighttime dose. Any tips on timing the evening dose or managing the nausea would also be appreciated.

Thanks for reading.

Hi everyone,
I’ve been lurking here for a while and finally wanted to introduce myself. I’m 68 and was a dedicated amateur cyclist for decades — thousands of miles a year, group rides, solo adventures. Cycling was a huge part of my identity.
My symptoms were slowly increasing for a long time, but I’ve now been dealing with clear ME/CFS symptoms and associated PEM for about a year. An episode of vestibular neuritis in 2022 (likely viral) may have been an initiating event. These days my limit is around a one-mile walk. Anything beyond that and I pay for it with PEM, sometimes for several days.
I have a supportive psychiatrist and a therapist who understand that I can no longer do the athletic things I used to — that’s been meaningful during this adjustment. I’m strict with pacing using a Visible app and Garmin armband HRM, and I’m trying to find smaller sources of purpose now that my old life has changed so much. Have gotten into vintage hifi and serious music-listening.
Last Monday I started Low Dose Naltrexone (LDN) at 1.5 mg, largely because of the experiences and information shared in this community. My doctor was open to prescribing it, and I’m getting it compounded. I’m only a week in, so it’s very early days, but I’m hopeful and grateful this group brought it to my attention. Hoping for less frequent or severe crashes.
I’d really appreciate hearing from anyone who’s tried LDN for ME/CFS — what dosing and titration worked for you, how long it took to notice changes, and any tips for handling initial side effects like vivid dreams or sleep disruption.
Thanks in advance for any insights. This subreddit has already made me feel less alone. Thank you.